Kythera Acquires Rights to PGD2 Blocking Setipriprant for New Hair Loss Treatment

[It's2014ComeOnAlready]

Also, Kythera purchased cotsarellis' patents, but that doesn't mean they will follow those patents. From their shareholders presentation its pretty obvious they plan to develop and test this as a pill. Is it possible to make it a topical? who knows, probably. Either way the side effect shouldn't vary much.

No, the "novel" delivery method is part of the patent, which is what they purchased. It's not so obvious they will test this in pill form because they already have done that in healthy male and female patients.

[sdsurfin]

I only mention these side effects because the percentages were very high, the incidence of such effects is very high with other antihistamines, and there is a withdrawal effect from these drugs that is not talked about even by many doctors. There are always low percentages of people that report headaches and drowsiness, but not at these percentages. If that's too hard to understand I don't know how else to say it. Talk to anyone who has taken zyrtec. I too hope that the side effects will be outweighed by the positives. Just don't get your hopes too high.

Also, Kythera purchased cotsarellis' patents, but that doesn't mean they will follow those patents. From their shareholders presentation its pretty obvious they plan to develop and test this as a pill. Is it possible to make it a topical? who knows, probably. Either way the side effect shouldn't vary much.

[HairlossAt15]

How do you 100% know anything about this?

I know that it can be converted into a topical 100%, because they have already (for the last 2 years) been testing 5 different GPR44 Blockers (one of which is Setipriprant) on explanted human hairs. Obviously a pill cannot be digested by a hair follicle.

and in their shareholders presentation they clearly say it will be an oral drug

Again, you are misrepresenting the truth, they said it would be "Oral dosing (improved compliance)" i.e people will find it easier to take the drug orally, leading to more sales etc. If it is just as effective orally as it is topically, then why not? If not, I wouldn't mind a topical formulation. The point is, both are possible.

For anyone interested, a couple of years ago I created a thread with all the information I could find and my opinion.

https://www.baldtruthtalk.com/showthread.php?12865-Cotsarelis-Garza-Genetic-analysis&highlight=

Yes, this is all just basic science, and noone is saying it is a cure. There a no major side effects, headaches drowsiness etc are "side-effects" seen in almost every trial and some people think that something as trivial as a vitamin pill can give you those side effects...

The positives far way out the negatives, by leaps and bounds.

[Justinian]

Does anyone know why they are so vague when talking about the novel delivery method? It's patent protected right?

[Energizer]

If you look up follica's patents, they have many different ways of wounding. I know one of their techniques involved using lasers. They've put a lot of work into to developing the procedure - quite impressive. Check them out:
http://www.faqs.org/patents/assignee/follica-inc/

Thank you my friend. I will look at these.

I asked because earlier in this very long thread I read that the preventative treatment may be released in conjunction with bimatoprost and a wounding protocol for regrowth. I don't know if that was correct or not. I'm on a slow connection so it would take about five minutes to page back.

I have abnormal scarring so I would like to know if wounding would due more harm than good to me, were it ever to become viable.

We need a collection of all the available primary documents surrounding these new treatments so folks can look through them all in one place. I see people referencing "the articles" but they are linked sporadically. Maybe I'll collect them up.

[hellouser]

Here's the patent kythera purchased the rights to. It states the the application will be topical, although no mention has been made about the delivery, besides this.

https://www.google.com/patents/WO2013142295A1?cl=en

There's no mention of Kythera in that patent....

[noisette]

I don't know if you have ever seen this doc, so I share : http://files.shareholder.com/downloa...5BFA2E/KYTHERA


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[It's2014ComeOnAlready]

Here's the patent kythera purchased the rights to. It states the the application will be topical, although no mention has been made about the delivery, besides this.

https://www.google.com/patents/WO2013142295A1?cl=en

[hellouser]

We don't even know if trans-epidermal delivery is possible with this molecule.

It's molecular weight is only 402 dalton, it'll pass through skin quite easily.

[It's2014ComeOnAlready]

It's been posted, but I'll repost. Here's an audio recording from people at Kythera discussing this drug for hair loss:

https://clyp.it/41mcx0mb

[hellouser]

I find it funny that Costsarelis claimed he needed 20 millions to be "better than propecia", and the announcement claims they will get around 20 millions if they reach milestones.

Costarelis sells himself cheap. Is a potential MPB treatment just worth 20 millions? I don't know how good their royalties would be if it gets commercialised

No, the 20 million remark was in regards to a full cure. Therefor, a cure already exists.

[sdsurfin]

A topical treatment would be novel. Name a hair loss treatment that stops you from losing hair on every part of the scalp, that works topically.

Minoxidil only works on the crown, if it works at all.

No one ever said this will be a topical treatment. Their shareholder presentation states very clearly that they are using this as an oral drug. We don't even know if trans-epidermal delivery is possible with this molecule. It is also a drug that, even if used topically, does not disintegrate before it hits the bloodstream, meaning it will have the same sides.

People are having the same reaction to this as for the drug that is being tested for areata. sure, they might work, but a huge number of people might not be able to use it. Also, compounds that are very similar to this have been trialled by people online with not much success. Even people like cotsarellis are not aware of those results to some degree. Dr. Xu emailed me a few months back asking if people had had success with ramatroban. This drug may be quite good for prevention, but that's no blockbuster. In combination with something like BIM it might be really good, but BIM is another drug that has crap side effects so far. Id rather be bald than have swollen ****ed up eyes, a constant headache, and feel sleepy and fart all the time. Hopefully these sides will not occur or they will figure out a dosage that works to reduce them, I'm just saying don't get all too hyped up just yet. When a cell based treatment comes to fruition then I'll be excited.

[It's2014ComeOnAlready]

I feel like the average poster on here is <20 years old and hasn't yet learned how to think or write. How do you 100% know anything about this? This 2014 dude is killing me, please stop posting. All you do is speak from your hopes and use faulty logic. Just because a drug can theoretically do something doesn't mean it will. Ramatroban and cetrizine and OC are all compounds that are incredibly similar to Setipriprant, and none of them have been miraculous for balding. They have all had side effects, some quite serious. I was only trying to raise these issues before people go and get HTs hoping that this is the cure. We have no idea if this will come to fruition or whether it will work. A good example is Actelion's trials for the sea drug on allergies. They were convinced that it would work on allergies for 3 trials before they abandoned it. You don't know jack shit. I was pointing out that antihistamines can have really shitty side effects, that being drowsy all day or having a headache all day is not fun, and that I'd love for someone with an IQ higher than a rodent please ask a researcher or go to the clinic in san diego and ask about these things. It's not that complicated. And whoever was talking about the placebo effect, yes of course it can play a part, but they use placebos in trials! The side effect profile, which included headaches and drowsiness was incredible much higher than that for the placebo group, and is consistent with what people experience of well known antihistamines. Ask any dermatologist why people don't love to take zyrtec for years on end. It makes you tired and useless, and if you take it long enough, your body freaks out. I believe, from past trials, and from similarities in action, that this has the potential to do the same. Again, I believe it should be looked into before people start putting all their hopes on this being a more realistic drug to take than propecia.

Secondly, where did they say that they would be using a novel delivery technique? I cnt find that anywhere, and in their shareholders presentation they clearly say it will be an oral drug.

You're clearly the one without maturity, use of logic, and find it appropriate to hurl insults. Anyone who reads the material on PGD2 and then reads my comments will find that there's nothing I'm saying that's out-of-bounds.

[It's2014ComeOnAlready]

I have read the studies. A topical treatment isn't "novel". Minoxidil is topical.

Furthermore, you can find Cotsarelis's presentation at the World Congress for Hair research on Follica's website. That entire talk is about PGD2. He even explicitly mentions that a PGD2 antagonist type drug could be therapeutically beneficial. At the time he gave the presentation and Follica added it to their website, he was already under contract with Kythera. So, I'm not saying that it's the case for sure, but, there is ample reason to speculate that this very well could end up being used in conjunction with wounding.

A topical treatment would be novel. Name a hair loss treatment that stops you from losing hair on every part of the scalp, that works topically.

Minoxidil only works on the crown, if it works at all.

[bigentries]

What I want to know is how does any of this square with Costarelis's bizarre comments to Desmond at last year's hair loss conference in South Korea. From what I recall, Costarelis was aloof and seemed reluctant to engage or answer any questions, but at the same time was not above pleading for money.

I find it funny that Costsarelis claimed he needed 20 millions to be "better than propecia", and the announcement claims they will get around 20 millions if they reach milestones.

Costarelis sells himself cheap. Is a potential MPB treatment just worth 20 millions? I don't know how good their royalties would be if it gets commercialised