Kythera Acquires Rights to PGD2 Blocking Setipriprant for New Hair Loss Treatment

[Gerhard]

Not true. I really want to be positive about this one. I'm speculating based on the trials that people have run on very similar compounds since 2012. Look up "OC hair loss", you'll find lots of users who used a basically identical molecule with little effect. Also the side effects I listed are based on the results of the trials on asthma. 25 percent of people got headaches. And Gerhard, Not having a headache is crucial to my quality of life, as is not being tired all the time. Sex is important but I would take never having sex over having a pounding brain all the time. that sounds like a true nightmare. Both would definitely totally suck. But the brain comes at number one as far as what's important to me. Hair is not even in the top five as far as my manhood is concerned. My brain, my wit, my relationships, my honor, my body and probably more things rank above hair.

I'm not medically qualified enough to determine whether they're the same or similar compounds or not. For now, what's being presented sounds promising. If it doesn't pan out and is another bust I suppose I'll cope. I read those previously, however those side effects don't necessarily bother me all that much. Flatulence, headache, etc. are all relatively minor and probably easily fixable compared to the ED, gyno, etc. etc. of messing with your androgen levels. Perhaps it's because I'm a pretty sexually active 19 year old male, but the idea of no sex is honestly the thing that terrifies me of fina even while I'm taking it (thank the lord those morning woods are still coming). I like sex, it's extremely important to me. My body was more or less a culmination of my overall physical health and then my brain function as well (which fina supposedly can effect as well with brain fog and such).

Hellouser - Thanks for the link. Also, random thanks on my behalf for your posts in the RU section and in the trials you've done on yourself for the hairloss cause. It's greatly appreciated. What size of dermaroller would you suggest for the scalp? I believe I have a 1.5 laying around somewhere that I used for acne way back when.

[hellouser]

Not true. I really want to be positive about this one. I'm speculating based on the trials that people have run on very similar compounds since 2012. Look up "OC hair loss", you'll find lots of users who used a basically identical molecule with little effect. Also the side effects I listed are based on the results of the trials on asthma. 25 percent of people got headaches. And Gerhard, Not having a headache is crucial to my quality of life, as is not being tired all the time. Sex is important but I would take never having sex over having a pounding brain all the time. that sounds like a true nightmare. Both would definitely totally suck. But the brain comes at number one as far as what's important to me. Hair is not even in the top five as far as my manhood is concerned. My brain, my wit, my relationships, my honor, my body and probably more things rank above hair.

AGAIN:

OC is NOT this new stuff. Stop spreading misinformation.

[hellouser]

Molecular Weight is 402 dalton. Not the best but not too big to penetrate skin. Some dermarolling along with this would be pretty good!

http://www.keyorganics.net/bionet/setipiprant-mfcd23136043-c24h19fn2o3-1.html

[sdsurfin]

Not true. I really want to be positive about this one. I'm speculating based on the trials that people have run on very similar compounds since 2012. Look up "OC hair loss", you'll find lots of users who used a basically identical molecule with little effect. Also the side effects I listed are based on the results of the trials on asthma. 25 percent of people got headaches. And Gerhard, Not having a headache is crucial to my quality of life, as is not being tired all the time. Sex is important but I would take never having sex over having a pounding brain all the time. that sounds like a true nightmare. Both would definitely totally suck. But the brain comes at number one as far as what's important to me. Hair is not even in the top five as far as my manhood is concerned. My brain, my wit, my relationships, my honor, my body and probably more things rank above hair.

[Gerhard]

Having a headache and being fatigued nonstop would maybe be worse than losing your dick power.

What world do you live in, man? I'd gladly take a headache to retain my dick. I can quit and be free of a headache. With fina I could lose my dick. I don't know where you rank the importance of your manhood, but I personally put it in the top 3: dick, body, hair.

[It's2014ComeOnAlready]

I'm still skeptical. the same types of compounds (OC, which is highly potent in the same way, ramatroban) have been used by forum people with very little success. Also, the side effects of this, at least taken orally, don't sound fun. Also, I would absolutely not assume that they won't run many trials because it has been safety tested for other uses. Might shave a year off or so, but best believe they will still do efficacy and dosing studies, and who knows when they will start, so this is also nothing that's coming very soon. I would love to be proven wrong, they should really ask the people at the company this stuff. At least it's not bad news, but the fact that hair growth was not a standout effect in the asthma trials, and the side effect profile for this make me hold back on my enthusiasm. Having a headache and being fatigued nonstop would maybe be worse than losing your dick power.

Dude, all of what I'm saying is based on what's presented. All of what you're saying is negative speculation.

[sdsurfin]

There's a quote I posted from the Chief Medical Officer of Kythera saying that the compound works in the human hair pathway in all of their own studies. Also, I'm sure Cotsarelis had been using a similar formula in their follicular neogenesis trials. A study was published saying that pgd2 inhbits follicle neogenesis, so in order to actually run their trials, they would need a compound to inhibit pgd2. It must work, because Follica had run 2 trials, and still, a huge biopharmaceutical company wants to produce it.

I wouldn't underestimate this kind of news. It could be the kind of news a lot of people looking for a new treatment have been waiting on.

I'm still skeptical. the same types of compounds (OC, which is highly potent in the same way, ramatroban) have been used by forum people with very little success. Also, the side effects of this, at least taken orally, don't sound fun. Also, I would absolutely not assume that they won't run many trials because it has been safety tested for other uses. Might shave a year off or so, but best believe they will still do efficacy and dosing studies, and who knows when they will start, so this is also nothing that's coming very soon. I would love to be proven wrong, they should really ask the people at the company this stuff. At least it's not bad news, but the fact that hair growth was not a standout effect in the asthma trials, and the side effect profile for this make me hold back on my enthusiasm. Having a headache and being fatigued nonstop would maybe be worse than losing your dick power.

[It's2014ComeOnAlready]

That is just about what I was going to ask as well. If that's the case that's fantastic news.

I mean that whole page is blank except for 1. open an IND 2. Initiate a proof of concept.

[Gerhard]

Since this drug has done 8 clinical trials, a phase 3 safety, can anyone deny or confirm that all they need to do is a proof-of-concept?

That is just about what I was going to ask as well. If that's the case that's fantastic news.

[Gerhard]

Kythera is presenting tomorrow at the 2015 Leerink Global Healthcare Conference with livestreaming. Hmm. Apparently the video we be kept up for the next 2 weeks. Interesting.

Here's a link to the conference tomorrow at 10am. Check in the investor section: http://www.kytherabiopharma.com/

Thanks for updating this with some more info, 2014. It's greatly appreciated. Again, I'm not trying to get my hopes up but I'm reading over the pdf you posted. It's good to see a reputed biopharmaceutical company such as Kythera taking an interest in this. I hope to see more and more good news every day, guys.

[It's2014ComeOnAlready]

Since this drug has done 8 clinical trials, a phase 3 safety, can anyone deny or confirm that all they need to do is a proof-of-concept?

[It's2014ComeOnAlready]

WOW, holy crap this in informative:

http://files.shareholder.com/downloa...0Deck%209FEB15[1].pdf

[It's2014ComeOnAlready]

Quite. I'm not getting myself too excited, but it is a good and perhaps a very good step in the right direction.

Kythera is presenting tomorrow at the 2015 Leerink Global Healthcare Conference with livestreaming. Hmm. Apparently the video we be kept up for the next 2 weeks. Interesting.

Here's a link to the conference tomorrow at 10am. Check in the investor section: http://www.kytherabiopharma.com/

[Gerhard]

Never heard of this. What's the consensus? Promising?

Quite. I'm not getting myself too excited, but it is a good and perhaps a very good step in the right direction.

[It's2014ComeOnAlready]

Never heard of this. What's the consensus? Promising?

This basically says that all the work and rights to Cotsarelis' work with PGD2 belong to a company that is going to trial with an already existing a PGD2 antagonist for hair loss. It's all of the pgd2 stuff coming to fruition.