Kythera Acquires Rights to PGD2 Blocking Setipriprant for New Hair Loss Treatment

[sdsurfin]

Just look up setipriprant clinical trials.

Also, I'm not sure if any of this is worth getting excited about. there have been other compounds that do the same thing, such as OC000459 , which have been trialled by forum users without too much success. They seemed to sort of work but then stop working after a while. I think the whole PGD2 issue is only a part of the puzzle. Would definitely be good to talk to an expert about it.

[beetee]

Obviously going to take some time for this to follow its course and we don't know if it will be effective or not, but there's no doubt this goes in the good news category. I'll even put it in the very good news category.

[burtandernie]

Ill be perfectly honest that I would like to see some study or a little more evidence before getting my hopes too high, but this is the news of the year that no one saw coming. If this isnt crazy positive news I dont know what is. The fact this is based off the PGD2 discovery really lends this a ton of credibility and they said they already have solid evidence this actually works. News of the year IMO

[It's2014ComeOnAlready]

Ill be perfectly honest that I would like to see some study or a little more evidence before getting my hopes too high, but this is the news of the year that no one saw coming. If this isnt crazy positive news I dont know what is. The fact this is based off the PGD2 discovery really lends this a ton of credibility and they said they already have solid evidence this actually works. News of the year IMO

There's a quote I posted from the Chief Medical Officer of Kythera saying that the compound works in the human hair pathway in all of their own studies. Also, I'm sure Cotsarelis had been using a similar formula in their follicular neogenesis trials. A study was published saying that pgd2 inhbits follicle neogenesis, so in order to actually run their trials, they would need a compound to inhibit pgd2. It must work, because Follica had run 2 trials, and still, a huge biopharmaceutical company wants to produce it.

I wouldn't underestimate this kind of news. It could be the kind of news a lot of people looking for a new treatment have been waiting on.

[It's2014ComeOnAlready]

Also would add that the tolerability of this medication is the same to both men and women.

[It's2014ComeOnAlready]

They even finished a tolerability study on healthy men and women in Sept. 2013. The name of the doctor running the study was Daniela Baldoni! HAHA cannot make this stuff up.

http://www.clinicaltherapeutics.com/article/S0149-2918(13)00950-8/abstract

[x4342]

I liked this line:

"which together could enable KYTHERA to bring a new treatment to the very large and still highly unsatisfied hair loss market."


Yep.

[Jasari]

Never heard of this. What's the consensus? Promising?

[It's2014ComeOnAlready]

Never heard of this. What's the consensus? Promising?

This basically says that all the work and rights to Cotsarelis' work with PGD2 belong to a company that is going to trial with an already existing a PGD2 antagonist for hair loss. It's all of the pgd2 stuff coming to fruition.

[Gerhard]

Never heard of this. What's the consensus? Promising?

Quite. I'm not getting myself too excited, but it is a good and perhaps a very good step in the right direction.

[It's2014ComeOnAlready]

Quite. I'm not getting myself too excited, but it is a good and perhaps a very good step in the right direction.

Kythera is presenting tomorrow at the 2015 Leerink Global Healthcare Conference with livestreaming. Hmm. Apparently the video we be kept up for the next 2 weeks. Interesting.

Here's a link to the conference tomorrow at 10am. Check in the investor section: http://www.kytherabiopharma.com/

[It's2014ComeOnAlready]

WOW, holy crap this in informative:

http://files.shareholder.com/downloa...0Deck%209FEB15[1].pdf

[It's2014ComeOnAlready]

Since this drug has done 8 clinical trials, a phase 3 safety, can anyone deny or confirm that all they need to do is a proof-of-concept?

[Gerhard]

Kythera is presenting tomorrow at the 2015 Leerink Global Healthcare Conference with livestreaming. Hmm. Apparently the video we be kept up for the next 2 weeks. Interesting.

Here's a link to the conference tomorrow at 10am. Check in the investor section: http://www.kytherabiopharma.com/

Thanks for updating this with some more info, 2014. It's greatly appreciated. Again, I'm not trying to get my hopes up but I'm reading over the pdf you posted. It's good to see a reputed biopharmaceutical company such as Kythera taking an interest in this. I hope to see more and more good news every day, guys.

[Gerhard]

Since this drug has done 8 clinical trials, a phase 3 safety, can anyone deny or confirm that all they need to do is a proof-of-concept?

That is just about what I was going to ask as well. If that's the case that's fantastic news.