Kythera Acquires Rights to PGD2 Blocking Setipriprant for New Hair Loss Treatment

[It's2014ComeOnAlready]

That is just about what I was going to ask as well. If that's the case that's fantastic news.

I mean that whole page is blank except for 1. open an IND 2. Initiate a proof of concept.

[sdsurfin]

There's a quote I posted from the Chief Medical Officer of Kythera saying that the compound works in the human hair pathway in all of their own studies. Also, I'm sure Cotsarelis had been using a similar formula in their follicular neogenesis trials. A study was published saying that pgd2 inhbits follicle neogenesis, so in order to actually run their trials, they would need a compound to inhibit pgd2. It must work, because Follica had run 2 trials, and still, a huge biopharmaceutical company wants to produce it.

I wouldn't underestimate this kind of news. It could be the kind of news a lot of people looking for a new treatment have been waiting on.

I'm still skeptical. the same types of compounds (OC, which is highly potent in the same way, ramatroban) have been used by forum people with very little success. Also, the side effects of this, at least taken orally, don't sound fun. Also, I would absolutely not assume that they won't run many trials because it has been safety tested for other uses. Might shave a year off or so, but best believe they will still do efficacy and dosing studies, and who knows when they will start, so this is also nothing that's coming very soon. I would love to be proven wrong, they should really ask the people at the company this stuff. At least it's not bad news, but the fact that hair growth was not a standout effect in the asthma trials, and the side effect profile for this make me hold back on my enthusiasm. Having a headache and being fatigued nonstop would maybe be worse than losing your dick power.

[It's2014ComeOnAlready]

I'm still skeptical. the same types of compounds (OC, which is highly potent in the same way, ramatroban) have been used by forum people with very little success. Also, the side effects of this, at least taken orally, don't sound fun. Also, I would absolutely not assume that they won't run many trials because it has been safety tested for other uses. Might shave a year off or so, but best believe they will still do efficacy and dosing studies, and who knows when they will start, so this is also nothing that's coming very soon. I would love to be proven wrong, they should really ask the people at the company this stuff. At least it's not bad news, but the fact that hair growth was not a standout effect in the asthma trials, and the side effect profile for this make me hold back on my enthusiasm. Having a headache and being fatigued nonstop would maybe be worse than losing your dick power.

Dude, all of what I'm saying is based on what's presented. All of what you're saying is negative speculation.

[Gerhard]

Having a headache and being fatigued nonstop would maybe be worse than losing your dick power.

What world do you live in, man? I'd gladly take a headache to retain my dick. I can quit and be free of a headache. With fina I could lose my dick. I don't know where you rank the importance of your manhood, but I personally put it in the top 3: dick, body, hair.

[sdsurfin]

Not true. I really want to be positive about this one. I'm speculating based on the trials that people have run on very similar compounds since 2012. Look up "OC hair loss", you'll find lots of users who used a basically identical molecule with little effect. Also the side effects I listed are based on the results of the trials on asthma. 25 percent of people got headaches. And Gerhard, Not having a headache is crucial to my quality of life, as is not being tired all the time. Sex is important but I would take never having sex over having a pounding brain all the time. that sounds like a true nightmare. Both would definitely totally suck. But the brain comes at number one as far as what's important to me. Hair is not even in the top five as far as my manhood is concerned. My brain, my wit, my relationships, my honor, my body and probably more things rank above hair.

[hellouser]

Molecular Weight is 402 dalton. Not the best but not too big to penetrate skin. Some dermarolling along with this would be pretty good!

http://www.keyorganics.net/bionet/setipiprant-mfcd23136043-c24h19fn2o3-1.html

[hellouser]

Not true. I really want to be positive about this one. I'm speculating based on the trials that people have run on very similar compounds since 2012. Look up "OC hair loss", you'll find lots of users who used a basically identical molecule with little effect. Also the side effects I listed are based on the results of the trials on asthma. 25 percent of people got headaches. And Gerhard, Not having a headache is crucial to my quality of life, as is not being tired all the time. Sex is important but I would take never having sex over having a pounding brain all the time. that sounds like a true nightmare. Both would definitely totally suck. But the brain comes at number one as far as what's important to me. Hair is not even in the top five as far as my manhood is concerned. My brain, my wit, my relationships, my honor, my body and probably more things rank above hair.

AGAIN:

OC is NOT this new stuff. Stop spreading misinformation.

[Gerhard]

Not true. I really want to be positive about this one. I'm speculating based on the trials that people have run on very similar compounds since 2012. Look up "OC hair loss", you'll find lots of users who used a basically identical molecule with little effect. Also the side effects I listed are based on the results of the trials on asthma. 25 percent of people got headaches. And Gerhard, Not having a headache is crucial to my quality of life, as is not being tired all the time. Sex is important but I would take never having sex over having a pounding brain all the time. that sounds like a true nightmare. Both would definitely totally suck. But the brain comes at number one as far as what's important to me. Hair is not even in the top five as far as my manhood is concerned. My brain, my wit, my relationships, my honor, my body and probably more things rank above hair.

I'm not medically qualified enough to determine whether they're the same or similar compounds or not. For now, what's being presented sounds promising. If it doesn't pan out and is another bust I suppose I'll cope. I read those previously, however those side effects don't necessarily bother me all that much. Flatulence, headache, etc. are all relatively minor and probably easily fixable compared to the ED, gyno, etc. etc. of messing with your androgen levels. Perhaps it's because I'm a pretty sexually active 19 year old male, but the idea of no sex is honestly the thing that terrifies me of fina even while I'm taking it (thank the lord those morning woods are still coming). I like sex, it's extremely important to me. My body was more or less a culmination of my overall physical health and then my brain function as well (which fina supposedly can effect as well with brain fog and such).

Hellouser - Thanks for the link. Also, random thanks on my behalf for your posts in the RU section and in the trials you've done on yourself for the hairloss cause. It's greatly appreciated. What size of dermaroller would you suggest for the scalp? I believe I have a 1.5 laying around somewhere that I used for acne way back when.

[sdsurfin]

No sex is terrible, and I have felt firsthand propecia's effect on the brain.

I do have to correct my previous post, because I've been reading about other PGD2 blockers, and people seem to have maintained their hair completely while on them (search cetrizine). So as a maintenance technique I think this actually has a lot of promise. Not sure it will regrow anything, and I'm not sure if kerythea knows that either after reading their press release.

The side effects do scare me, there are several posters on the cetrizine thread that talk about withdrawal effects (severe itching, massive headaches) after stopping oral use of cterizine after prolonged use. I think I will probably hop on the cetrizine train though for now, I can't take propecia or minox and maybe if I can hold on to what I've got for a few years something better will come along. I'm skeptical of replicel but still cautiously hopeful that it might be a long term fix.

[It's2014ComeOnAlready]

No sex is terrible, and I have felt firsthand propecia's effect on the brain.

I do have to correct my previous post, because I've been reading about other PGD2 blockers, and people seem to have maintained their hair completely while on them (search cetrizine). So as a maintenance technique I think this actually has a lot of promise. Not sure it will regrow anything, and I'm not sure if kerythea knows that either after reading their press release.

The side effects do scare me, there are several posters on the cetrizine thread that talk about withdrawal effects (severe itching, massive headaches) after stopping oral use of cterizine after prolonged use. I think I will probably hop on the cetrizine train though for now, I can't take propecia or minox and maybe if I can hold on to what I've got for a few years something better will come along. I'm skeptical of replicel but still cautiously hopeful that it might be a long term fix.

Everything about this news seems to have gone completely over your head. This is all of Follica and Cotsarelis' work with pgd2 about to go into a trial. Could be just one trial because 3 safety trials were already completed in both men and women (and 8 trials total), the only thing they haven't done is test their topical formulation. You are off jabbering about nothing.

[Gerhard]

Everything about this news seems to have gone completely over your head. This is all of Follica and Cotsarelis' work with pgd2 about to go into a trial. Could be just one trial because 3 safety trials were already completed in both men and women (and 8 trials total), the only thing they haven't done is test their topical formulation. You are off jabbering about nothing.

Perhaps I read it wrong, but I thought they were going to go with an oral formula. Was I incorrect in that?

[It's2014ComeOnAlready]

Perhaps I read it wrong, but I thought they were going to go with an oral formula. Was I incorrect in that?

I don't believe it listed the delivery or the type of vehicle. I just assumed it was topical because Cots said all along it would be topical. Plus oral doses have already gone through trials with healthy adult men and women.

[sdsurfin]

Everything about this news seems to have gone completely over your head. This is all of Follica and Cotsarelis' work with pgd2 about to go into a trial. Could be just one trial because 3 safety trials were already completed in both men and women (and 8 trials total), the only thing they haven't done is test their topical formulation. You are off jabbering about nothing.

Do you read anything? The press release from Kythera states very clearly that they will test this as an oral formulation. Nothing about topicals. Also, they very clearly posted their side effects in their clinical studies. I am not saying this is useless. Other PGD2 blockers have already proven to completely halt hair loss. However, even the scientists do not have the testing knowledge that online users do. This is a different compound, which is good, but it is very similar, and probably has similar side effects. Prolonged users of cetrizine report very bad withdrawals with itching and headaches when they go off the drug. I'm guessing the same will happen with this one after prolonged oral usage, though I can't be certain obviously. I'm still encouraged that new info on hair loss is being put to use, and I plan to go on topical cetrizine immediately.

Also there is no reason to think that clinical trials will not be done as a separate thing for hair loss. Im sure they will test the efficacy and dosage in prolonged trips before they spend the money to market this for AA.

[sdsurfin]

Read the press release. It's oral.

[It's2014ComeOnAlready]

Read the press release. It's oral.

I read it. I'm pretty sure you're not getting the context. It's saying that Setipiprant is in it's current form, a selective oral antagonist of pgd2. We know that. The press release does not mention in which form it will be delivered. Do you get the difference?

Cotsarelis' numerous suggestions that it would be delivered topically is still a possibility, because we don't know yet how it will be applied.