Kythera Acquires Rights to PGD2 Blocking Setipriprant for New Hair Loss Treatment

[Gerhard]

If this truly ends up being an oral drug (if it ever even comes out), i sure as **** wont be taking it as i've learned my lesson from Propecia.

Propecia affects your DHT levels. PGD2 inhibition would be an entirely different case.

Let me rephrase that sentence so it makes more sense. Maybe if your reading comprehension was beyond a high school level, you could communicate more effectively.

Ugh, you ugly little internet troll.

You are rather narrow-minded at times, 2014. All he has done is ask some viable questions about the drug. You don't need to be so utterly defensive about it. If you'd have continued reading his post rather than bolding the aforementioned sentences and reacting defensively towards them you'd have realized that he is as excited and hopeful for this treatment as you.

Try and be more courteous to others. Being bald may be bad, but being rude is simply awful.

[Thinning@30]

What I want to know is how does any of this square with Costarelis's bizarre comments to Desmond at last year's hair loss conference in South Korea. From what I recall, Costarelis was aloof and seemed reluctant to engage or answer any questions, but at the same time was not above pleading for money.

[It's2014ComeOnAlready]

Propecia affects your DHT levels. PGD2 inhibition would be an entirely different case.



You are rather narrow-minded at times, 2014. All he has done is ask some viable questions about the drug. You don't need to be so utterly defensive about it. If you'd have continued reading his post rather than bolding the aforementioned sentences and reacting defensively towards them you'd have realized that he is as excited and hopeful for this treatment as you.

Try and be more courteous to others. Being bald may be bad, but being rude is simply awful.

People have been hurling insults at me. I've tried to answer questions and express my excitement through facts, and nothing more. I have read everything that has to do with everything about PGD2 and its relation to hair loss. I think most people are uninformed and don't want to accept any of what I'm saying because 1. they're used to bad news. 2. They want to read a fancy news piece, then they'll accept it.

I'm trying to educate people on why this is the most promising treatment to come, but they want to ask uninformed questions, and not read up on the material themselves. I'm trying to spread positivity, and I'm being told that I don't know how to use logic, or that my reading comprehension is on a high school level.

[barfacan]

Can it be formulated as a topical?

[hellouser]

People have been hurling insults at me. I've tried to answer questions and express my excitement through facts, and nothing more. I have read everything that has to do with everything about PGD2 and its relation to hair loss. I think most people are uninformed and don't want to accept any of what I'm saying because 1. they're used to bad news. 2. They want to read a fancy news piece, then they'll accept it.

I'm trying to educate people on why this is the most promising treatment to come, but they want to ask uninformed questions, and not read up on the material themselves. I'm trying to spread positivity, and I'm being told that I don't know how to use logic, or that my reading comprehension is on a high school level.

Who cares dude... you're about to get what looks to be a solid treatment against hair loss. If they keep moaning, it's not going to take away the hair you get back

[HairlossAt15]

Hey guys let's not argue anymore, let's only post more news.

Can it be formulated as a topical?

Yes, it 100% can

[RGPHILPA]

Well, one of the company's founders is backing a rival company and giving the rights to a potential treatment. They are probably involved in some way

Oh, I see what you're saying. Yes, I agree with you. It would be quite the conflict of interest for Cotsarelis to go into business with another company going after MPB. I imagine Puretech ventures would have quite a bit to say about that. Unless of course, they're involved.

[sdsurfin]

Hey guys let's not argue anymore, let's only post more news.



Yes, it 100% can

I feel like the average poster on here is <20 years old and hasn't yet learned how to think or write. How do you 100% know anything about this? This 2014 dude is killing me, please stop posting. All you do is speak from your hopes and use faulty logic. Just because a drug can theoretically do something doesn't mean it will. Ramatroban and cetrizine and OC are all compounds that are incredibly similar to Setipriprant, and none of them have been miraculous for balding. They have all had side effects, some quite serious. I was only trying to raise these issues before people go and get HTs hoping that this is the cure. We have no idea if this will come to fruition or whether it will work. A good example is Actelion's trials for the sea drug on allergies. They were convinced that it would work on allergies for 3 trials before they abandoned it. You don't know jack shit. I was pointing out that antihistamines can have really shitty side effects, that being drowsy all day or having a headache all day is not fun, and that I'd love for someone with an IQ higher than a rodent please ask a researcher or go to the clinic in san diego and ask about these things. It's not that complicated. And whoever was talking about the placebo effect, yes of course it can play a part, but they use placebos in trials! The side effect profile, which included headaches and drowsiness was incredible much higher than that for the placebo group, and is consistent with what people experience of well known antihistamines. Ask any dermatologist why people don't love to take zyrtec for years on end. It makes you tired and useless, and if you take it long enough, your body freaks out. I believe, from past trials, and from similarities in action, that this has the potential to do the same. Again, I believe it should be looked into before people start putting all their hopes on this being a more realistic drug to take than propecia.

Secondly, where did they say that they would be using a novel delivery technique? I cnt find that anywhere, and in their shareholders presentation they clearly say it will be an oral drug.

[bigentries]

What I want to know is how does any of this square with Costarelis's bizarre comments to Desmond at last year's hair loss conference in South Korea. From what I recall, Costarelis was aloof and seemed reluctant to engage or answer any questions, but at the same time was not above pleading for money.

I find it funny that Costsarelis claimed he needed 20 millions to be "better than propecia", and the announcement claims they will get around 20 millions if they reach milestones.

Costarelis sells himself cheap. Is a potential MPB treatment just worth 20 millions? I don't know how good their royalties would be if it gets commercialised

[It's2014ComeOnAlready]

I have read the studies. A topical treatment isn't "novel". Minoxidil is topical.

Furthermore, you can find Cotsarelis's presentation at the World Congress for Hair research on Follica's website. That entire talk is about PGD2. He even explicitly mentions that a PGD2 antagonist type drug could be therapeutically beneficial. At the time he gave the presentation and Follica added it to their website, he was already under contract with Kythera. So, I'm not saying that it's the case for sure, but, there is ample reason to speculate that this very well could end up being used in conjunction with wounding.

A topical treatment would be novel. Name a hair loss treatment that stops you from losing hair on every part of the scalp, that works topically.

Minoxidil only works on the crown, if it works at all.

[It's2014ComeOnAlready]

I feel like the average poster on here is <20 years old and hasn't yet learned how to think or write. How do you 100% know anything about this? This 2014 dude is killing me, please stop posting. All you do is speak from your hopes and use faulty logic. Just because a drug can theoretically do something doesn't mean it will. Ramatroban and cetrizine and OC are all compounds that are incredibly similar to Setipriprant, and none of them have been miraculous for balding. They have all had side effects, some quite serious. I was only trying to raise these issues before people go and get HTs hoping that this is the cure. We have no idea if this will come to fruition or whether it will work. A good example is Actelion's trials for the sea drug on allergies. They were convinced that it would work on allergies for 3 trials before they abandoned it. You don't know jack shit. I was pointing out that antihistamines can have really shitty side effects, that being drowsy all day or having a headache all day is not fun, and that I'd love for someone with an IQ higher than a rodent please ask a researcher or go to the clinic in san diego and ask about these things. It's not that complicated. And whoever was talking about the placebo effect, yes of course it can play a part, but they use placebos in trials! The side effect profile, which included headaches and drowsiness was incredible much higher than that for the placebo group, and is consistent with what people experience of well known antihistamines. Ask any dermatologist why people don't love to take zyrtec for years on end. It makes you tired and useless, and if you take it long enough, your body freaks out. I believe, from past trials, and from similarities in action, that this has the potential to do the same. Again, I believe it should be looked into before people start putting all their hopes on this being a more realistic drug to take than propecia.

Secondly, where did they say that they would be using a novel delivery technique? I cnt find that anywhere, and in their shareholders presentation they clearly say it will be an oral drug.

You're clearly the one without maturity, use of logic, and find it appropriate to hurl insults. Anyone who reads the material on PGD2 and then reads my comments will find that there's nothing I'm saying that's out-of-bounds.

[sdsurfin]

A topical treatment would be novel. Name a hair loss treatment that stops you from losing hair on every part of the scalp, that works topically.

Minoxidil only works on the crown, if it works at all.

No one ever said this will be a topical treatment. Their shareholder presentation states very clearly that they are using this as an oral drug. We don't even know if trans-epidermal delivery is possible with this molecule. It is also a drug that, even if used topically, does not disintegrate before it hits the bloodstream, meaning it will have the same sides.

People are having the same reaction to this as for the drug that is being tested for areata. sure, they might work, but a huge number of people might not be able to use it. Also, compounds that are very similar to this have been trialled by people online with not much success. Even people like cotsarellis are not aware of those results to some degree. Dr. Xu emailed me a few months back asking if people had had success with ramatroban. This drug may be quite good for prevention, but that's no blockbuster. In combination with something like BIM it might be really good, but BIM is another drug that has crap side effects so far. Id rather be bald than have swollen ****ed up eyes, a constant headache, and feel sleepy and fart all the time. Hopefully these sides will not occur or they will figure out a dosage that works to reduce them, I'm just saying don't get all too hyped up just yet. When a cell based treatment comes to fruition then I'll be excited.

[hellouser]

I find it funny that Costsarelis claimed he needed 20 millions to be "better than propecia", and the announcement claims they will get around 20 millions if they reach milestones.

Costarelis sells himself cheap. Is a potential MPB treatment just worth 20 millions? I don't know how good their royalties would be if it gets commercialised

No, the 20 million remark was in regards to a full cure. Therefor, a cure already exists.

[It's2014ComeOnAlready]

It's been posted, but I'll repost. Here's an audio recording from people at Kythera discussing this drug for hair loss:

https://clyp.it/41mcx0mb

[hellouser]

We don't even know if trans-epidermal delivery is possible with this molecule.

It's molecular weight is only 402 dalton, it'll pass through skin quite easily.