Kythera Acquires Rights to PGD2 Blocking Setipriprant for New Hair Loss Treatment

[DanWS]

Cotsarelis' numerous suggestions that it would be delivered topically is still a possibility, because we don't know yet how it will be applied.

On the technology platform Follica are reported to be using...

Like most baldness procedures it sounds mildly terrifying: they start with a process called 'skin-peturbation' where the top layers of the scalp are peeled back. The cells beneath then revert to a stem-cell like state, and a topical solution is applied to the area that re-boots the cells to start producing hair.

http://www.huffingtonpost.co.uk/2013/09/09/baldness-cure-prevention-follica-_n_3892684.html

[sdsurfin]

I read it. I'm pretty sure you're not getting the context. It's saying that Setipiprant is in it's current form, a selective oral antagonist of pgd2. We know that. The press release does not mention in which form it will be delivered. Do you get the difference?

Cotsarelis' numerous suggestions that it would be delivered topically is still a possibility, because we don't know yet how it will be applied.

I meant the investors release. not the press release. The press release doesn't say anything but the other one does. It specifically says it its oral. Also, DanWS this has nothing to do with follica other than the fact that cotsarellis is involved with both things. This will not involve wounding or topicals or any of that. These guys are working on different things at once. Actually the fact that they have sold off the rights to the PGD2 research only makes it clearer that the whole wounding thing has probably been abandoned. Cotsarellis' research on PGD2 action is what has been purchased by kythera, not follica or that line of inquiry.

[sdsurfin]

http://files.shareholder.com/downloa...0Deck%209FEB15[1].pdf


that's the link. look it up yourself.

[sdsurfin]

This is a comment from two years ago on another forum just goes to show how crowdsourced info is always ahead of the curve these days. I'm pretty positive this drug is going to have some efficacy, especially and maintaining hair, but also pretty sure the side effects are not gonna be fun. This is not baseless speculation, look online for what people say about cetrizine or other similar compounds. Drowsiness and headaches are big time, and both came up in the clinical trials for this drug too. Still, might be worth taking until someone comes out with a cell based treatment.



"TaKeeLa

23.03.2012, 12:14

@ TaKeeLa
PGD2 RECEPTOR 2 ANTAGONIST (BLOCKER)
» These aren't the same receptors? You are saying DP2 and CRTH2 not PGD2??

I think this is what you are looking for....

Setipiprant by Actelion blocks the right PGD2 receptor implicated in MPB (PD2). Right now, setipiprant is in phase 2/3 testing. "

[HairlossAt15]

Most important part:




Hairs grows as normal when PGD2 blocked, this is human hair!

[walrus]

I'm skeptical of replicel but still cautiously hopeful that it might be a long term fix.

Even if things like replicel work, you will still probably need something like this to normalise prostaglandin levels in the scalp and avoid going back to square one.

[Jonathan]

According to to shareholders info:
During 2015/16
- Open an IND for sepiprant
- Initiate a Proof-of-Concept study for sepiprant

...It will take time before it hits the stores so lets find a way to get hold of sepiprant and make our own proof-of-concept instead of whining about how long everything takes and that no one cares. Now we actually have a chance to do something ourselves. The product has been tested to be safe, so what are we waiting for? It could be as simple as this:

1. We find one dedicated member that can organize this (PM)
2. Every one in here helps to vacuum the internet to find the best source that can provide sepiprant.
3. When the source is validated by the most knowledgeable members in here, maybe we even can lab test the drug to make sure its legit.
4. PM is collecting money and info regarding age,sex,current regimes etc from users who want to participate in this study and buys a big stock of sepiprant.
5. PM is distributing sepiprant to the participants and collects weekly photos from them and publish them on a web page in an organized way (participants only get the drug if he/she provides photos). If we get many participants we could even try different strengths etc without telling the participant (but no placebo for sure)

...then 6 months from now we know if its working or not!. I would not mind taking the PM role if i am trusted, but I live in Sweden and that is maybe not optimal place distribution wise. I think its important that all participants use same source and that we have one guy in the middle that organizes it, so not everyone is doing it their own way and it end up as usual with 100 diverting result that you don't know what to trust.

Let me know if any one else thinks this is a good idea.

[Hairismylife]

According to to shareholders info:
During 2015/16
- Open an IND for sepiprant
- Initiate a Proof-of-Concept study for sepiprant

...It will take time before it hits the stores so lets find a way to get hold of sepiprant and make our own proof-of-concept instead of whining about how long everything takes and that no one cares. Now we actually have a chance to do something ourselves. The product has been tested to be safe, so what are we waiting for? It could be as simple as this:

1. We find one dedicated member that can organize this (PM)
2. Every one in here helps to vacuum the internet to find the best source that can provide sepiprant.
3. When the source is validated by the most knowledgeable members in here, maybe we even can lab test the drug to make sure its legit.
4. PM is collecting money and info regarding age,sex,current regimes etc from users who want to participate in this study and buys a big stock of sepiprant.
5. PM is distributing sepiprant to the participants and collects weekly photos from them and publish them on a web page in an organized way (participants only get the drug if he/she provides photos). If we get many participants we could even try different strengths etc without telling the participant (but no placebo for sure)

...then 6 months from now we know if its working or not!. I would not mind taking the PM role if i am trusted, but I live in Sweden and that is maybe not optimal place distribution wise. I think its important that all participants use same source and that we have one guy in the middle that organizes it, so not everyone is doing it their own way and it end up as usual with 100 diverting result that you don't know what to trust.

Let me know if any one else thinks this is a good idea.

Count me in. But what means by IND?

[Jonathan]

Count me in. But what means by IND?

http://www.fda.gov/drugs/developmentapprovalprocess/howdrugsaredevelopedandapproved/approvalapplications/investigationalnewdrugindapplication/default.htm

[sosa56]

Is anyone able to listen to this http://leerink.metameetings.com/conf...hp?ticker=KYTH

Might contain useful info

[It's2014ComeOnAlready]

I'm pretty sure they would need to do one trial only. They have trialled this drug 8 times, have gotten through the fda hurdles. I'm assuming they're going to prepare a new formulation that needs to be tested, and given the extensive and well known safety profile, only need to know if it works.

I'm sure they already know it works. Otherwise you wouldn't have this company buying the rights to produce it and run one trial. The company isn't even a huge pharmaceutical like merck or gsk or actavis.

[It's2014ComeOnAlready]

Count me in. But what means by IND?

It allows the company to transport the investigational drug across state lines for means of research. Since this is already a heavily investigated drug with 8 clinical trials, 7 pubished papers etc they probably won't have any trouble getting it.

[beetee]

The chief medical officer of Kythera that's quoted in the press release used to be the chief medical officer of Allergan and was the go-to guy to explain bimatiprost for hair during their conference calls. Might not mean much (or anything) but if we could download the contents of his brain on here we'd probably know some interesting things about the potential for both of these treatments.

[beetee]

C

[It's2014ComeOnAlready]

The chief medical officer of Kythera that's quoted in the press release used to be the chief medical officer of Allergan and was the go-to guy to explain bimatiprost for hair during their conference calls. Might not mean much (or anything) but if we could download the contents of his brain on here we'd probably know some interesting things about the potential for both of these treatments.

You guys have literally been missing all the signs. Both work on prostaglandins, one stops hair loss, the other will regrow. It is the holy grail of treatments. Bimatoprost finished up its phase 2b study back in Nov when Allergan was sold for $13 billion more than any company was willing to offer. They planned on releasing their info for their phase 2b study in January, are now saying you'll have to wait for those results until 2016. Also, setipiprant has an excellent safety profile with over 1,000 men and women being tested. Not to mention that it has passed 8 trials. It would only need to do a proof-of-concept to test the efficacy of the application. Even the optimal dose has already been determined.

All those years of research by Cotsarelis and Follica, are now being funneled into one proof-of-concept trial. Then we have new treatments. Holy crap.