Bimatoprost finishing up Phase IIb trial!

[35YrsAfter]

The article doesn't go into a lot of detail about that:

"Though hypertrichosis of lashes is a regular side effect, hirsutism as seen in our patient is very rare. The patient had a few terminal (non-vellus) hairs in the chin area and upper lip before commencing bimatoprost but they have increased in number, thickness and length after the treatment. Hypertrichosis of eyelashes is reported to be more and occurs earlier with bimatoprost. The resting follicles (telogen phase) are stimulated to growing follicles (anagen phase) due to interaction of the drugs with the prostanoid receptors in the hair follicle. The anagen phase of eyelashes may be prolonged which could increase their length. This same mechanism would apply for localized hypertrichosis elsewhere."

35YrsAfter also posts as CITNews and works at Dr. Cole's office - forhair.com - Cole Hair Transplant, 1045 Powers Place, Alpharetta, Georgia 30009 - Phone 678-566-1011 - email 35YrsAfter at chuck@forhair.com
The contents of my posts are my opinions and not medical advice
Please feel free to call or email me with any questions. Ask for Chuck

[Jonathan]

My English language skills is not good enough to fully understand the article, but unwanted facial hair is pretty common for elderly ladies. How do they know that its the bimatoprost that is the reason behind that facial hair?

[35YrsAfter]

I am only interested in if bimatoprost works or not.

This NCBI article indicates that after this lady stopped using bimatoprost, the hair didn't go away. She was using the medication in her eyes as opposed to applying it directly to the areas shown in the photos where hair growth occurred. Quote from article/study:

"Though the patient always had minimal non-vellus hair growth in the same regions, this had increased in number, thickness and length after starting bimatoprost [Figure 1]. The patient's IOPs were maintained at target level. The patient's medical history was unremarkable with no intake of any other drugs. The prostaglandin analogue was stopped and instead dorzolamide and timolol fixed combination was started. When the patient came seven months later, the hair growth did not show significant reduction."



Article HERE

35YrsAfter also posts as CITNews and works at Dr. Cole's office - forhair.com - Cole Hair Transplant, 1045 Powers Place, Alpharetta, Georgia 30009 - Phone 678-566-1011 - email 35YrsAfter at chuck@forhair.com
The contents of my posts are my opinions and not medical advice
Please feel free to call or email me with any questions. Ask for Chuck

[Jonathan]

I'm personally more interested in how bimatoprost works. Same goes for minoxidil.

Chuck

I am only interested in if bimatoprost works or not.

[35YrsAfter]

We have no idea about how much this is going to cost, the 300 to 500 price range is a simple guess of what we beleive this should cost but if it becomes a reality the price can be totally different
Let's wait to get information about the actual results and then we can worry about pricing
Hopefully they will let us known phase 2 results before the end of the month

I'm personally more interested in how bimatoprost works. Same goes for minoxidil.

Chuck

[efedrez]

So this is just an expensive, glorified version of minoxidil.

Great

We have no idea about how much this is going to cost, the 300 to 500 price range is a simple guess of what we beleive this should cost but if it becomes a reality the price can be totally different
Let's wait to get information about the actual results and then we can worry about pricing
Hopefully they will let us known phase 2 results before the end of the month

[hellouser]

So this is just an expensive, glorified version of minoxidil.

Great

LOL, making this kind of call based on all the noobs in this thread just speculating is pretty ridiculous.

1) None of us knows how well the stuff works at higher concentrations
2) None of us knows the price

[gainspotter]

So this is just an expensive, glorified version of minoxidil.

Great

[diffuseloser]

500 a year is okay, but not 500 per MONTH, or I will give up on this.

500 a year would be reasonable but we'll be lucky if it's that cheap. I'd easily pay 1k sterling a year provided it works a good bit better than minoxidil.

[Hairismylife]

They have to be somewhat competitive, you price it too high and youll get into HT price territory and people will just opt to do that instead.

i'd say 300-500 a year for this stuff at first, which is high but reasonable based on production cost and lack of competition.

500 a year is okay, but not 500 per MONTH, or I will give up on this.

[rdawg]

I'm affraid that this stuff is going to be crazy expensive when it will first come out. But yeah, if the results are great I guess it's worth it. Besides, beggars can't be choosers right...

They have to be somewhat competitive, you price it too high and youll get into HT price territory and people will just opt to do that instead.

i'd say 300-500 a year for this stuff at first, which is high but reasonable based on production cost and lack of competition.

[burtandernie]

Yeah price on any new treatment is going to be painful in the pharma industry. The big thing here just being proof of the importance for prostaglandins which gives a lot of credibility to pgd 2 being important too. Maybe lowering the bad with pgd 2 and raising the good with this at the same time can compound the results but who knows really
Hopefully this gets good results and low incidence of sides. I think people are pretty desperate for anything really that gets any growth

[Illusion]

I'm affraid that this stuff is going to be crazy expensive when it will first come out. But yeah, if the results are great I guess it's worth it. Besides, beggars can't be choosers right...

[It's2014ComeOnAlready]

If the results at 0.03% are somewhat decent and can occur ANYWHERE on the scalp, I'd be willing to bet BIG on this having results enough for a new product at 10%. Think about it, it's 333X the concentration of something that already works alright, somewhat comparable to minoxidil. Given the recent knowledge about prostaglandins, this will give further proof to the science and hopefully bring in a new era of treatments.

If this does turn out to work, I think you could see a company like follica coming forward and putting their product out as well. There's just too much opportunity for money to be made, because the combo would be the holy grail of treatments. To any of the naysayers regarding Follica, do you really think they've been sitting on this discovery and not readying themselves with a product?

Cotsarelis has said they will need to team with a company to figure out a new treatment, yea well it's Merck. Yaping Liu, a senior investigator from Merck has her name all over Garza's studies regarding PGD2. When Cots was getting through his presentation at the hair congress this summer, he thanked all the people who helped him with this work. When he went to announce where they work, he deliberately mumbles and kind of says "Merck" under his breath when it came time to tell us where Yaping Liu works. Start at the 24:00 mark of his presentation on youtube if interested. It's very telling IMO.

Also, Merck's patent on Propecia has already run out, or I believe it's been extended for a year? Either way, that's coming to an end as well.

[rdawg]

What happens if the results still suck at even 10% concentration?

Then they wont go into phase III and the product won't be released.

It should get better results though at a higher concentration, 0.03% is extremely low, but obviously there's a chance a higher dose will just be better for those that already responded at the low dose.

who knows, the results will be interesting.