Bimatoprost finishing up Phase IIb trial!

[beetee]

For all those with questions about release date, see my reply to the very well informed FearTheLoss below.

[sascha]

So, then you know the results of the phase IIb studies that were just recently completed? Please share, we'd love to know.

The phase 2 study is over, results will be out in January 2015. I do not get the guys that come on this forum and do not even know whats going on, even if such things are adressed by JFSI every week on the show.

[Swooping]

So, then you know the results of the phase IIb studies that were just recently completed? Please share, we'd love to know.

Ah. Sorry that one I obviously don't know but i was meaning the clinical trial before 2b in which they had used 0.03% 0.1% and 0.3% bimatoprost on each 60 subjects each vs a placebo vehicle and minoxidil solution 5%. Minoxidil outperformed bimatoprost in that clinical trial (http://clinicaltrials.gov/show/NCT01325337)

I think in 2b they only trial 2 bimatoprost solutions and a placebo vehicle right? They don't compare to minoxidil (http://clinicaltrials.gov/show/NCT01904721)

If what you say is true they must be using a pretty high dosage I suppose. We'll see i guess hopefully they will post results again.

[It's2014ComeOnAlready]

So, then you know the results of the phase IIb studies that were just recently completed? Please share, we'd love to know.

[Swooping]

He said that he'd been hearing that the results from the phase IIb bim study had excellent results, superior to minoxidil, and would have some people coming off Propecia and minoxidil to use it instead. Spencer actually said that he'd been hearing the same as well. However, the facts are only that Johnson and Johnson was at one point looking to buy Allergan (around April), but it didn't pan out. As we know also, Valeant was trying to buy Allergan, but that didn't happen, and yesterday Actavis did.

Actavis stated in the buyout that they believe that with this combination, they'll become a top-10 pharmaceutical company. Allergan's biggest revenue maker is botox at this point, and there is nothing in their pipeline that looks like it could be extremely popular or a cash-cow. Actavis purchased the company for 13 billion more than anyone else was willing to offer at $219 a share, and the stock even jumped.

Something's going on, yet it's easy to be doubtful until those results are posted.

It didn't have superior results to minoxidil, minoxidil 5% outperformed bimatoprost on every concentration tested.

[hellouser]

All the rumors behind it also suggest that the results are excellent. Joe from SI called in to Spencer's show last week and had been hearing this was the case, and Spencer agreed with him fully.

That's a bit of a stretch. To them, any results are good results.

[It's2014ComeOnAlready]

All the rumors behind it also suggest that the results are excellent. Joe from SI called in to Spencer's show last week and had been hearing this was the case, and Spencer agreed with him fully.

[FearTheLoss]

Bim will be out next year if the results are good, not 2020. I don't know where you got that false information.

[It's2014ComeOnAlready]

Next year for bim, not 6 years.

[Gjm127]

so 6 more years...? to finish phaseIIb and phase 3? This is depressing... It's already been tested for eyelashes, can't they bypass anything?

All I see that's real close is Replicel... funny how it used to be the furthest a year ago.

[beetee]

If trial results will be good enough, how long do you think it will take until bimatoprost comes out to market?

There was an interview with allergan CEO David pyott on cnbc after they reported the results of the first phase 2 trial, and he gave an expected date of 2020. For anyone that's disappointed by that I would add two things. It will be an absolute miracle if we see a cure in our lifetimes. We'll be the luckiest balding SOBs that ever lived if anything comes out, let alone in the next five years. Also, this is far from certain. While it's an interesting possibility, there have been many others in the past that didn't pan out. We just don't know yet what if anything this can do.

[rambo007]

If trial results will be good enough, how long do you think it will take until bimatoprost comes out to market?

[It's2014ComeOnAlready]

Interesting! And this is at .1% concentration. I believe the current trials are testing 1-10% concentrations, pretty exciting.

[beetee]

This article has been brought up in other threads but I figured it would be appropriate to post on it here. The authors conducted a small scale study using Latanoprost (essentially the same thing as Bimatoprost/Latisse, from my understanding) on human subjects and found that it stimulated regrowth of hair on the scalp:

Ulrike Blume-Peytavi et al., A randomized double-blind placebo-controlled pilot study to assess the efficacy of a 24-week topical treatment by latanoprost 0.1%, Journal of the American Academy of Dermatology Vol. 66, p. 794-800 (2012).

This formulation was just that already available, so it is not indicative of what could happen with stronger concentrated formulas.

From the findings:

"At 24 weeks at the latanoprost-treated site, the density (22% in the entire study population) was significantly higher compared with baseline and placebo. As vellus hairs increased on both investigational sites, the vehicle may also have stimulated hair growth."

This was a small scale study with young men with relatively mild cases of hair loss. The authors also state that similar regrowth had been shown in studies of Minoxidil. So it's not clear what the ultimate significance is, but this is an actual study on the scalps of human balding men.

[noisette]

Regardless, I saw that Dr. Alan Bauman had been getting results all over the top of the scalp with bim (although I'm not sure of the concentration he was using). So, if you've still got some thinning spots while on fin, you could probably take care of those. If a PGD2 inhibitor comes on the market sometime, and you've got bim, you're looking at one of the best things to happen for guys with hair loss, maybe ever. If you've started thinning, or have been for a couple of years, it can be reversed with these drugs. I just hope Cots an Follica hurry the hell up.

Anybody who wants to see a video from Doctor Bauman : http://youtu.be/FIOhiVwmVm0