adipose-derived stem cell protein extract

[hgs1989]

I'm sure a lot of you have already read this:

Valerie Horsley, Associate Professor of Molecular, Cellular, and Developmental Biology, hypothesized that adipocyte precursor cells were directly responsible for hair follicle growth by inducing the activation of follicular stem cells.

The team used various experimental methods, including histology and functional analysis, to visualize the interactions between the adipocyte lineage cells and the follicular stem cells. Several mouse models with genetic mutations at different stages of the adipogenesis pathway were used to see more specifically how adipocyte lineage cells contribute to the regulation of follicular stem cells. One mouse model with a defect in adipocyte precursor proliferation resulted in a significant decrease in hair growth levels. Transplanting wild-type adipocyte precursor cells into regions where such precursors were lacking in the mutant mice, however, prompted hair growth. Additional tests showed that adipocyte precursors drive platelet derived growth factor (PDGF) signaling, a process that induces the hair follicle’s initiation of the growth phase. The data collected from these experiments showed that adipocyte precursor cells are both necessary and sufficient to drive hair follicle growth.

35YrsAfter also posts as CITNews and works at Dr. Cole's office - forhair.com - Cole Hair Transplant, 1045 Powers Place, Alpharetta, Georgia 30009 - Phone 678-566-1011 - email 35YrsAfter at chuck@forhair.com
The contents of my posts are my opinions and not medical advice
Please feel free to call or email me with any questions. Ask for Chuck

why woudln't dr cole try it ? it is autologus so the need for fda approval is not necessary. take a look at those people
http://www.balancehairrestoration.com . they are the ones that I got the papaer that started this thread. and I read on their website that they have a treatment using stormal vascular fraction ;which is rich in stem cells and growth factors ;as a an injection and also provide a topical growth factor secreted by your own cells. I guess it would be intresting to see the outcomes. maybe adding prp to the mix. I dont expect mund blowing results especially if it is marketed as a one time treatment. but with tweeking it might be successful from the first time.

[hellouser]

why woudln't dr cole try it ? it is autologus so the need for fda approval is not necessary. take a look at those people
http://www.balancehairrestoration.com . they are the ones that I got the papaer that started this thread. and I read on their website that they have a treatment using stormal vascular fraction ;which is rich in stem cells and growth factors ;as a an injection and also provide a topical growth factor secreted by your own cells. I guess it would be intresting to see the outcomes. maybe adding prp to the mix. I dont expect mund blowing results especially if it is marketed as a one time treatment. but with tweeking it might be successful from the first time.

Cole's making too much money off ACELL and other dubious treatments. He's not going to cannibalize sales just to potentially give you more hair. He's a businessman first... 'Doctor' is just his title.

[Arashi]

HGS1989 check this out: since Jahoda is now using a construct that let's him add these same adipose derived stem cells to DP cells to create and enlarge follicles this means that if we get these adipose derived stem cells injections (Swiss clinic or greece clinic or Vienna clinic) we would be doing the same thing that Jahoda is doing, except that we would be doing it in our scalps whereas Jahoda is doing it in a petri-dish.

Let me say it again. Check this out:

* Jahoda is adding these cells to dp cells so he can grow and enlarge follicles.

* We would be putting these cells into our scalps to enlarge the existing follicles that are already in our scalps.

* This means we would be doing the same thing that Jahoda is doing except we would be doing it in the skin of our scalps instead of inside a petri-dish.



Also, an important note is that the Yale scientists discovered that the adipose precursor cells excrete 100 times as much of some growth factors as regular fat cells excrete. By injecting pure precursor cells (adipose derived stem cells) you are injecting 100 times more growth factors as you would if you just injected regular fat cells. So the key to this is to add the precursor fat cells, aka adipose derived stem cells so that you can bomb the follicles with the growth factors.

Wow. You really never cease to amaze me jarjar. You compress so much nonsense into your sentences that someone should give you an award for it. I am not even sure where to start ... You seem to confuse jahodas idea about adding fat cells to his experiments with the idea of injecting stem cells. And really, 'enlarge follicles', haha, what makes you think jahoda wants bigger follicles ?

Adsc really have pretty much nothing to do with jahodas research. He is trying to figure out signaling between fat cells and follicles

[hgs1989]

Wow

you already said that you will stop arguing with him, yet here you ready for another god knows how much posts and quotes that will kill the thread. would you guys please stop it ?!

[Arashi]

you already said that you will stop arguing with him, yet here you ready for another god knows how much posts and quotes that will kill the thread. would you guys please stop it ?!

I never said I would stop arguing with jarjar. As long as he posts bs that can hurt people I will correct him. I just said I didn't want to argue anymore about off topic posts about how he scared Dr Aaron Gardner away.

Jarjar has a history of trying to push people to do experimental unproven treatments so he can watch from his chair how others take risks for him and put their money on the line to see if it works. But if he does that with posting lies, like he does here, he needs to be corrected.

[gainspotter]

you already said that you will stop arguing with him, yet here you ready for another god knows how much posts and quotes that will kill the thread. would you guys please stop it ?!

Not that much else to talk about anyway

[Swooping]

Nameless did you give prostemics a call already?

[35YrsAfter]

Cole's making too much money off ACELL and other dubious treatments. He's not going to cannibalize sales just to potentially give you more hair. He's a businessman first... 'Doctor' is just his title.

Giving men, and in some cases women the maximum amount of hair possible is the dream of every hair restoration doctor I know. It's a win win, for the doctor and the patient. BTW, ACell's no money maker. It's expensive and we give too much of it away. We know it's effective and repair patients in particular benefit from both ACell and PRP.

Chuck

[35YrsAfter]

why woudln't dr cole try it?

Safety and effectiveness.... Dr. Cole is looking into it.

Chuck
Dr. Cole's office

[nameless]

Wow. You really never cease to amaze me jarjar. You compress so much nonsense into your sentences that someone should give you an award for it. I am not even sure where to start ... You seem to confuse jahodas idea about adding fat cells to his experiments with the idea of injecting stem cells. And really, 'enlarge follicles', haha, what makes you think jahoda wants bigger follicles ?

Adsc really have pretty much nothing to do with jahodas research. He is trying to figure out signaling between fat cells and follicles

* Gardner said Jahoda will add fat cells rather than growth factors themselves in his efforts to grow hair. Yale says that in mice the "adipose precursor cells" are the cells that signal follicles to grow hair. The human equivalent to adipose precursor cells would probably be adipose derived stem cells. Hence, Gardner is likely talking about ADSCs because those are the fat cells that likely excrete the signals to the follicles to grow hair. Also, Yale said that the precursor cells produce 100 times the amount of some growth factors as generic fat cells do,

* I don't recall seeing where Gardner said that Jahoda will try to figure out the signaling between fat cells and follicles. Although it doesn't really matter because Gardner said Jahoda will use fat cells instead anyway, please provide a link to the post where Gardner said Jahoda is going to try to figure out the signaling between fat cells and follicles. Myself, I see no point for Jahoda to waste time figuring out these signals unless Jahoda intends to add the growth factors themselves, which Gardner says Jahoda is not going to do. Why bother trying to figure out the signals between fat cells and follicles if you're going to use the cells themselves? If you use the cells themselves the cells will take care of adding the correct signalling so you don't need to figure it out.

* Lab grown follicles don't start out as fully formed follicles. If they started out as fully formed follicles you wouldn't have researchers trying to create follicles. They start out as cells and then they form into follicles. And they also start out smaller and get bigger as part of their formation.

* If I said Jahoda would "inject" the ADSCs into his mix I meant to say "add" ADSCs. No biggie. You're making a big deal of nothing. Obviously I was comparing Jahoda adding ADSCs to his mix and us injecting these cells into our scalps so I used the word "inject" where I meant to say "add" because I was thinking about both ends of that equation at the same time and I inadvertently transposed the word "inject" for the word "add." I can't believe you would actually make a big deal of this. I guess you're scraping the bottom of the barrel for my grammar errors because you're feeling pissy about me pointing out how you proclaimed that the 2014 hair loss congress researchers solved the trichogenicity problem and how you accused needhairasap of being in cahoots with the Pilox folks. LOL!

[nameless]

you already said that you will stop arguing with him, yet here you ready for another god knows how much posts and quotes that will kill the thread. would you guys please stop it ?!

hgs you have to remember that this is the same Arishi who first said that the 2014 hair loss congress researchers solved the trichogenicity problem and now says he never said that, and accused needhairasap of being in cahoots with the Pilox marketers to cheat us, and other mistaken concepts. Of course he can't stick to his own assurances. He doesn't get much of anything right. So he said he would stop attacks and of course that means that he is going to continue attacks.

[nameless]

Nameless did you give prostemics a call already?

No I haven't. But I have been talking to the European clinics who are starting to use pure ADSC injections. And in some cases they're even culturing the cells. What do you think about this Swooping?

I asked about them giving a group discount and they said they would be open to the idea of a group discount.

I'm a little concerned about the ADSCs (compared to AAPE) because ADSCs are larger and more solid than AAPE so the cells might not get into every nook and cranny compared to the AAPE but once injected the cells might continuously excrete the desired growth factors so the follicles might get continuously bathed in these desired growth factors whereas with AAPE you might need injections once a week or so at least in the beginning. What do you think?

[nameless]

I never said I would stop arguing with jarjar. As long as he posts bs that can hurt people I will correct him. I just said I didn't want to argue anymore about off topic posts about how he scared Dr Aaron Gardner away.

Jarjar has a history of trying to push people to do experimental unproven treatments so he can watch from his chair how others take risks for him and put their money on the line to see if it works. But if he does that with posting lies, like he does here, he needs to be corrected.

I didn't scare Dr. Gardner away. After careful analysis I determined that you and your dud bud ssudsurfin (sp) scared him away. He got tired of ssudsurfin's lengthy posts and your constant mistakes. And he didn't even see your silly-@ss accusation post that needhairasap is in cahoots with the Pilox marketers to cheat bald people. LOL! I think that if he saw your post about the 2014 hair loss congress researchers solving all of the trichogencity issues he would probably want to know what you're talking about.

And if you're going to correct mistakes will you start by correcting your own mistakes? Will you admit that it was a silly and paranoid mistake for you to accuse needhairasap of being in cahoots with Pilox marketeers to cheat bald guys and will you admit that it was stupid of you "assume" that the 2014 hair loss congress researchers had solved all of the trichogencity problems?

[nameless]

Wow. You really never cease to amaze me jarjar. You compress so much nonsense into your sentences that someone should give you an award for it. I am not even sure where to start ... You seem to confuse jahodas idea about adding fat cells to his experiments with the idea of injecting stem cells. And really, 'enlarge follicles', haha, what makes you think jahoda wants bigger follicles ?

Adsc really have pretty much nothing to do with jahodas research. He is trying to figure out signaling between fat cells and follicles

I'm not confusing anything. Jahoda adding ADSC to his cell mixes to create laboratory follicles is the same as the Swiss company adding ADSCs to our scalps to grow follicles in our scalps. In both cases ADSCs are being added to grow follicles. And of course when follicles are grown in labs, enlargement is part of that process, so of course follicles are being enlarged in the lab process of growing follicles. They start out as cells and from that they form and grow into (hopefully) full follicles. And of course when Gardner talks about adding fat he is talking about ADSCs because ADSCs are the cells that Yale said were the correct cells. In the mouse world they're called "adipose precursor cells and in the human world they're called adipose derived stem cells. They equate. And adipose precursor cells are the cells that emit the signals to prompt follicle growth. Check this out:

http://news.yale.edu/2011/09/01/yale-scientists-find-stem-cells-tell-hair-its-time-grow

"Adipose precursor cells"

[Arashi]

* Gardner said Jahoda will add fat cells rather than growth factors themselves in his efforts to grow hair.

You just keep on confusing things !! Dr Gardner said that there are several inherent problems with growth factors, like steep production costs, difficulties to produce and short half life. Therefore, he concludes, it would make more sense to try to induce the scalp to secrete growth factors as an alternative to injecting them directly. He never said anything about effectiveness, just that adding growth factors themselves doesn't make sense to him. See: https://www.baldtruthtalk.com/showth...l=1#post174467

* I don't recall seeing where Gardner said that Jahoda will try to figure out the signaling between fat cells and follicles.

That's because you were too busy firing stupid questions at him. If you would have read his ANSWERS you would have realized that his research has NOTHING to do with those injections you are interested in. He even posted a link to Jahoda's work on fat cells. I'm sure you haven't read it. https://www.baldtruthtalk.com/showth...l=1#post174908

please provide a link to the post where Gardner said Jahoda is going to try to figure out the signaling between fat cells and follicles.

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0059811

https://www.baldtruthtalk.com/showthread.php?t=16284&p=174908&viewfull=1#post174908

Myself, I see no point for Jahoda to waste time figuring out these signals

LOL, yeah you know everything so much better than Jahoda. I'm still waiting for your first paper, that should be interesting, LOL But of course his research is VERY important because as you can read in his paper, it turns out fat cells (not just those stem cells or growth factors you are interested in, but really the WHOLE adipose LAYER) turn out to play a role in follicle development.

* Lab grown follicles don't start out as fully formed follicles. If they started out as fully formed follicles you wouldn't have researchers trying to create follicles. They start out as cells and then they form into follicles. And they also start out smaller and get bigger as part of their formation.

LOL, nice story bro. But you miss the point of course, as usual. Jahoda is interested in restoring inductivity, not in creating 'larger' follicles like you suggest, haha.

If I said Jahoda would "inject" the ADSCs into his mix I meant to say "add" ADSCs. No biggie. You're making a big deal of nothing. Obviously I was comparing Jahoda adding ADSCs to his mix and us injecting these cells into our scalps so I used the word "inject" where I meant to say "add" because I was thinking about both ends of that equation at the same time and I inadvertently transposed the word "inject" for the word "add." I can't believe you would actually make a big deal of this. I guess you're scraping the bottom of the barrel for my grammar errors because you're feeling pissy about me pointing out how you proclaimed that the 2014 hair loss congress researchers solved the trichogenicity problem and how you accused needhairasap of being in cahoots with the Pilox folks. LOL!

No, you are throwing in the "Jahoda uses this stuff too !!" argument, to seduce people into trying this for you, while you can watch from your relaxing chair, without any risks or costs how it works out. You tell people lies in the hope they will try it for you.