WCHR 2014 Presentations (Community-funded)

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  • joachim
    Senior Member
    • May 2014
    • 559

    all i can tell is: money can move mountains!!!

    if linder/lauster say, with the right amount of money, they can optimize their bioreactor within 3 years (or even less) and willing to sell it to interested doctors in the carribian or wherever else to enable earlier treatments, then i can tell you, i'm able to get millions of dollars ready, from a lot of different sponsors and big companies. even no need for crowdfunding, although it would be also very helpful and raise awareness all over the world.

    i think hellouser is the best one for this job. i see his frustration with all the incompetent researchers and at the same time his eagerness to change the world for a better. this is exactly what we need here.
    i want to thank you for your efforts and your passion for solving that disease.
    along with desmond and arashi, you form the golden trio here. the contribution of you three is awesome, and i hope you never lose your good spirit.

    i really hope you move forward with the crowdfunding idea... i believe, once a company can show us a working quasi-cure (e.g. lindner) which only has to be optimized and go through trials, then 100 million usd will be reached within 6 months. we only have to raise awareness all over the world. celebs should get to know about the campaign and that there is a solution close. many of them will then pitch in a lot of money. rooney, travolta, jude law, and sooooooo many others. also big CEOs and managers who have millions ready on their bank account will pitch some hundred thousand in, once they are aware of the campain.

    but the 100 million question is: what the f*** is holding all the researching teams back? i hope desmond has the right answer and allowed to talk about it. otherwise we seriously should try to get in touch with lindner and talk about the next possible steps. money needed or not? earlier release in different countries possible or not? i can't wait anymore.
    what a shame we are in 2014 and hairloss is still such a depressing problem.

    Comment

    • hellouser
      Senior Member
      • May 2012
      • 4419

      Originally posted by nameless
      Only 1 phase remaining if you would be happy with a treatment that is a little better than minoxidil or propecia.
      You have nothing to base that on that its a little better. Even if it were, it'd still be better than the best we have available today. Yeah, we should have a cure by now, but I would definitely go in for a treatment if available.

      Comment

      • hellouser
        Senior Member
        • May 2012
        • 4419

        Originally posted by bigentries
        But what trials?

        I'm not sure if anybody has seen this before. It looks like follica concluded phase two trials in Europe at the beginning of last year. Click on the DE to get more info. https://www.clinicaltrialsregister.eu/ctr-search/search?query=follica


        People were claiming those trials in advanced stage are just the lithium trials, there was conflicting reports about what stage follica really is
        Desmond just had Dr. Cotsarelis tell him that Follica finished Phase II last year.

        Comment

        • bigentries
          Senior Member
          • Dec 2011
          • 465

          Originally posted by hellouser
          Desmond just had Dr. Cotsarelis tell him that Follica finished Phase II last year.
          That's the thing, they also said the same thing last year to everyone, while they also talked about "pre clinical trials" elsewhere

          No one in that thread understood what it meant. Apparently the only trial registered that went to Phase II was the lithium trial, but they seem to have other things going on

          Comment

          • Thinning87
            Senior Member
            • Dec 2012
            • 839

            Originally posted by hellouser
            Next week I'll be posting a comprehensive list of roles required for such a venture. I've worked on a cancer research fund before, so this isn't new to me. You'll see what's required to make this work properly.

            Indiegogo (a crowdfunding site) has a pretty awesome and thorough explanation of what should be done for a crowdfunding campaign to be successful:

            http://go.indiegogo.com/playbook/life-cycle-phase
            Very good post. I will read this tonight

            Comment

            • nameless
              Senior Member
              • Feb 2013
              • 965

              Originally posted by hellouser
              You have nothing to base that on that its a little better. Even if it were, it'd still be better than the best we have available today. Yeah, we should have a cure by now, but I would definitely go in for a treatment if available.

              I've been focused on work all day today but it is my recollection that Desmond said that Cotseralis told him that for $2 mill he could get a treatment to market that would be slightly stronger than minoxidil/propecia. Now I admit that I've been focused on work all day and haven't seen Desmond's post for hours so I definitely could be misquoting him.

              The thing is that I would not want to go through a lot of trouble for a treatment that was only a little better than minox/propecia. It isn't going to improve my appearance much so I would not bother with it myself. Now if you have a small amount of loss then it might be more interesting to you.

              Comment

              • Thinning87
                Senior Member
                • Dec 2012
                • 839

                Originally posted by hellouser
                Desmond just had Dr. Cotsarelis tell him that Follica finished Phase II last year.
                I promise you he is referring to the well known phase 2A they finished a couple of years ago

                Comment

                • Maxis
                  Junior Member
                  • May 2014
                  • 3

                  If Follica truly has something promising then why aren't they getting continues funding from the VC firms that already funded their series A and B rounds?

                  Comment

                  • joachim
                    Senior Member
                    • May 2014
                    • 559

                    Originally posted by hellouser
                    They finished Phase II last year and have only 1 phase remaining... thats pretty close to a release.
                    are you talking about the lithium stuff? wounding with lithium lotion?
                    would be a good of course. if it's better than minox and fin. something to bridge the gap before a full cure.

                    and if they get 2 million from us, how long does it take to release it? i assume at least 3 years.
                    that's no option.

                    i would say this to cots: we will easily get you the 2 millions but under the following conditions: start phase 3 which is required to complete the fda BS, but allow others in unrestricted countries to license your technology and enable treatments NOW. alternatively, he doesn't have to license it to others and reveal his know how but then he have to set up a clinic in one of these countries instead. i think we all agree that we don't care about phase 3 at all if phase 1 and phase 2 showed safety and some cosmetically good results already, even if not perfect and far from a full head of hair.

                    if he agrees to that, i'll prepare the 2millions cash for him, within weeks =)
                    treatment NOW is the only option. not 10 years, not 5, and not even 2 years. (assuming that the wounding with lithium technology is available already)

                    Comment

                    • rdawg
                      Senior Member
                      • Jun 2012
                      • 996

                      Originally posted by Maxis
                      If Follica truly has something promising then why aren't they getting continues funding from the VC firms that already funded their series A and B rounds?
                      Same thing could be asked of Histogen.

                      It's possible that the companies funding this stuff feel that the money needed to continue the trials isnt worth it unless it's a full blown cure.

                      It costs millions to bring this stuff to market so some of them may not feel the risk is justified if the product is only 10% better than Minoxidil for example but costs twice as much.

                      return of investment right.

                      However we of course want more options and I think these companies are wrong, I guarentee you many people would spend the extra money just for another option. Min+Fin only maintain for guys like me with agressive hairloss at a young age(22).

                      I think Crowdfunding should be used, I think these guys underestimate how much we'd be willing to invest.

                      Comment

                      • hellouser
                        Senior Member
                        • May 2012
                        • 4419

                        Originally posted by joachim
                        are you talking about the lithium stuff? wounding with lithium lotion?
                        would be a good of course. if it's better than minox and fin. something to bridge the gap before a full cure.

                        and if they get 2 million from us, how long does it take to release it? i assume at least 3 years.
                        that's no option.

                        i would say this to cots: we will easily get you the 2 millions but under the following conditions: start phase 3 which is required to complete the fda BS, but allow others in unrestricted countries to license your technology and enable treatments NOW. alternatively, he doesn't have to license it to others and reveal his know how but then he have to set up a clinic in one of these countries instead. i think we all agree that we don't care about phase 3 at all if phase 1 and phase 2 showed safety and some cosmetically good results already, even if not perfect and far from a full head of hair.

                        if he agrees to that, i'll prepare the 2millions cash for him, within weeks =)
                        treatment NOW is the only option. not 10 years, not 5, and not even 2 years. (assuming that the wounding with lithium technology is available already)
                        It won't be up to Dr. Cotsarelis to decide on this but rather up to Follica and Puretech Ventures. I highly doubt they'd agree to it...

                        Comment

                        • nameless
                          Senior Member
                          • Feb 2013
                          • 965

                          Originally posted by hellouser
                          You have nothing to base that on that its a little better. Even if it were, it'd still be better than the best we have available today. Yeah, we should have a cure by now, but I would definitely go in for a treatment if available.

                          Now that I have gone back to see what Desmond actually said I might have some interest in this $2 million idea. I stand corrected Hellrouser.

                          I would want to know if Cotseralis would be able to put a ballpark percentage improvement over minox/propecia a patient could typically expect. If it was significant I would be willing to contribute.

                          Here is exactly what Desmond said:


                          "3) I brought up the crowdfunding idea particularly with regards to Follica and he said the amount necessary is quite large. So I insisted on an actual amount and here's what he said: "US $2 million would bring out a product that would be more effective than Minoxidil and Propecia but would not give a bald person a full head of hair. US $20 million will provide the kind of funding necessary to give someone who is already bald a full head of hair but it will take more years to accomplish"."

                          Comment

                          • hellouser
                            Senior Member
                            • May 2012
                            • 4419

                            Originally posted by rdawg
                            Same thing could be asked of Histogen.

                            It's possible that the companies funding this stuff feel that the money needed to continue the trials isnt worth it unless it's a full blown cure.

                            It costs millions to bring this stuff to market so some of them may not feel the risk is justified if the product is only 10% better than Minoxidil for example but costs twice as much.

                            return of investment right.

                            However we of course want more options and I think these companies are wrong, I guarentee you many people would spend the extra money just for another option. Min+Fin only maintain for guys like me with agressive hairloss at a young age(22).

                            I think Crowdfunding should be used, I think these guys underestimate how much we'd be willing to invest.
                            These guys underestimate how willing balding men and women are to use any and ALL options available. They're stupid if they feel that not enough people will spend money on their product. People spend copious amounts of cash on GARBAGE products today... the industry is in the billions of dollars per year. Can you imagine what that number would if we had products that actually WORKED?

                            Comment

                            • Haircure
                              Senior Member
                              • May 2014
                              • 126

                              I know this may be a big shot in the dark but, I'm sure a lot of you guys know about LeBron James and his now infamous hairline. Well apparently he's fed up with it and had gotten a hair transplant along with recently partnering with Hair Club for men. I know it's a slim chance but the guy is in contact with fans a lot and maybe he might be willing to help out.

                              Comment

                              • nameless
                                Senior Member
                                • Feb 2013
                                • 965

                                Desmond, what we want to know is the scientific technique how we could mass pass cultures of dp cells and epithelial cells while protecting trichogenicity/inductivity.

                                Also, there is going to be a presentation that shows better ways to insert the cells into the scalp. Please see that presentation and ask the presenter any questions you can think of. This is a very important presentation because I think that a lot of these cells are dying during re-implantation after culture.

                                Thanks Desmond.

                                Come back with lots of info, details, and the blueprints.

                                Comment

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