Final Days: Chinese Scientists Have Solved the DP Culturing Problem! (2014)

[Atum]

I really believe if a blueprint for a cure is found, things will progress much faster than anyone would expect. The first country to offer this treatment would see a ton of investment from drug companies looking to be auxillary as part of the regimen, to hair clinics looking to legally offer the treatment. Universities will boom with research grants looking into production and packaging of the product. Medical tourism will skyrocket.

Indeed, if this get's released in china in 1 or 2 years time, i better start learning chinees, cause I will be there.

[hellouser]

Anyway, now almost 10 years later (after publication of the European paper, for example), I always find it amusing when some baldies get excited when some "scientists" on this planet create some hairs in a petri dish - or "a" wispy hair on a mouse's back.... and start "the final cure is near" trash.

If these are some 'scientists' what does that make 'Dr. Gho' ??

[tonypizza]

I really believe if a blueprint for a cure is found, things will progress much faster than anyone would expect. The first country to offer this treatment would see a ton of investment from drug companies looking to be auxillary as part of the regimen, to hair clinics looking to legally offer the treatment. Universities will boom with research grants looking into production and packaging of the product. Medical tourism will skyrocket.

[534623]

Face it IM these asian guys are killing the game right now, way more intelligent, capable and dedicated compared to most euro/NA researchers

Not really. Oh, and why I called all this "trash science":

European researchers did this ...

To show the DP cells didnt lose their follicle inducing ability (like normally happens when culturing DP cells), they even induced some hair like fibers. But all in a dish !! This is TOTALLY different than growing REAL hair (like Tsuji did) on skin. This doesnt somehow show the Chinese failed (like you make it look) at all.

...while I, IN FACT, said this concerning the latter part (ADHD is still a big problem these days lol) ...

The Chinese scientists "failed" insofar (it wasn't their intention to produce with this approach fully functional hair follicles) and produced just "hair-like fibers", because their source lacked the proper instructions ...

...already in 2005:

"Reorganization of hair follicles in human skin organ culture induced by cultured human follicle-derived cells" - "Experimental Dermatology" (Bd. 14, S. 580; August 2005)

So they didn't just produce "hair-like fibers" in a petri dish (again, it wasn't the intention of the Chinese scientists to produce fully functional hair follicles, as already mentioned!!), they even produced real growing and functional "VELLUS-LIKE HAIR" in a petri dish. And to accomplish the latter, of course, they could also already retain the DP cells (and others) HF inducing capability (otherwise no hair at all!) - in 2005!

btw - Even the title of the European scientists paper is pretty similar to the papers' title from the Tsuij lab scientists:
It's all about "how-to" REORGANIZE/RECONSTRUCT hair follicles; the European scientists did it simply in vitro (in a petri dish) and the Tsuij lab guys did a simlar approach finally in vivo (after some pre-culturing in vitro); in this case in a mouse to produce at least "a" wispy hair.

Furthermore, the ADHD-guy is still thinking that using INTACT dermal papilla's (or plural "papillae") is completely the same thing than using just CELLS of intact dermal papilla's ...lol

On the other hand, it doesn't matter anyhow, because many don't even know what "reconstruction" or "reorganization" of something actually means ...lol

Anyway, now almost 10 years later (after publication of the European paper, for example), I always find it amusing when some baldies get excited when some "scientists" on this planet create some hairs in a petri dish - or "a" wispy hair on a mouse's back.... and start "the final cure is near" trash.

[lurker77]

Thats great news lets hope something good comes out!

on a side note...guys i have been in these forums for years and i have never seen a character like iron man before lol. The guy is hilariously psychotic. Thank god there are posters like Arashi in here or his scientifically dressed BS would confuse people!

Not just THESE forums, but any forums on any topic. People like him are a rare breed. Obsessed, delusional, and deranged. At a certain point I stopped being irritated and started just feeling bad for the guy.

[Number47]

Thats great news lets hope something good comes out!

on a side note...guys i have been in these forums for years and i have never seen a character like iron man before lol. The guy is hilariously psychotic. Thank god there are posters like Arashi in here or his scientifically dressed BS would confuse people!

[hellouser]

Just had a discussion with another forum member on ***, this is particularly interesting:

If I understand the first post correctly, they've come up with a way to clone hair. Why would it take 5 years? Why can't they transplant that hair right away? If it isn't a drug why would it need to be tested for safety? Transplanting hair is already established as being safe.

Why couldn't a hair transplant surgeon fly there tomorrow with a sample of your hair, come back with you when just 5 days later when it's finished cloning and transplant it on your head?

I agree somewhat but I would still want AT LEAST one safety trial followed by a second larger safety trial. If the treatment works, it will be known RIGHT AWAY from the first safety trial as the results will be stupidly obvious; either hair is there or not! I wouldn't want to transplant follicles that contain anything dangerous and risk something far greater than hair loss/social rejection.

I really don't think efficacy trials will be needed... that should be easily determined from a single safety trial.

I see what youre sayign though! If they're already follicles, what is so different from them coming from a donor area via traditional hair transplant. It's not like we're injecting pure stem cells that MAY turn into something else. These would be fully functioning and COMPLETED organoids, ie; follicles.

So that being said; if the cells turn into follicles... what's the point of going through so many trials?

[garethbale]

Good points guys! We need to figure out what can be done to get this treatment out the door as fast as possible and put us out of our misery! I dont care where I have to travel in the world to get this.

Whichever country releases it first will see a nice revenue stream, remember:

Money > Empathy

What about Somalia, North Korea or Syria?

[hellouser]

I hope the European Medicines Agency works faster than the FDA.

How does the process compare to the likes of Japan, China even India?

Good points guys! We need to figure out what can be done to get this treatment out the door as fast as possible and put us out of our misery! I dont care where I have to travel in the world to get this.

Whichever country releases it first will see a nice revenue stream, remember:

Money > Empathy

[Atum]

I hope the European Medicines Agency works faster than the FDA.

[JDW]

How does the process compare to the likes of Japan, China even India?

[hellouser]

The proof required for FDA approval should vary by the treatment and its approach. I would argue a topical that has some evidence it works like CB 03 01 poses much less of a risk then say a new immune system drug that is not similar to anything previously done. Require 2 phases for a less dangerous drug and 3 for more risky stuff. If you cant tell just make it the usual but some stuff just has a lot less risk then others.

Two really good videos touching on the FDA's retarded approval process:

https://www.youtube.com/watch?v=Ww57tmmecDc

https://www.youtube.com/watch?v=ccZLitYuWwQ

Doesn't matter, USA isn't the only country in the world (thank god) so as I've said before, a strong push needs to be made to boycott the FDA and take your business elsewhere.

[burtandernie]

The proof required for FDA approval should vary by the treatment and its approach. I would argue a topical that has some evidence it works like CB 03 01 poses much less of a risk then say a new immune system drug that is not similar to anything previously done. Require 2 phases for a less dangerous drug and 3 for more risky stuff. If you cant tell just make it the usual but some stuff just has a lot less risk then others.

[rdawg]

That's what safety trials are for. I'm not saying we should bypass all the trials and let biotechs have a free-for-all, my argument is that the average 10-15 years for a new drug to hit the market is unacceptable. Nearly all of us don't have 15 years to wait on a new treatment approved by the FDA... if even approved.

15 years is total bullshit.

Should be a two-phase system rather than 3.

1st is initial safety phase for one year.

2nd is large safety/efficacy phase for 2 years(part one is big group just for safety, then 2nd year is bigger group for efficacy if it passes)

after that maybe a limited release then extended. I just never understand when a company like say Histogen proves efficacy, but then they have to pay millions for a third phase just to get the same results.

[hellouser]

There are legitimate risks that must be considered.

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That's what safety trials are for. I'm not saying we should bypass all the trials and let biotechs have a free-for-all, my argument is that the average 10-15 years for a new drug to hit the market is unacceptable. Nearly all of us don't have 15 years to wait on a new treatment approved by the FDA... if even approved.

15 years is total bullshit.