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I was really interested in Pilofocus when we all first heard about it, but the fact is... its not going to achieve anything that's not already achievable. FUE and Acell/PRP can already do for all intents and purposes: scarless FUE. Look at Dr Cole's results. The only way it could be better is if it was cheaper and faster.
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The pictures you show us don't mean anything, see this guy in real life and then you can tell me how scarless FUE really is. If pilofocus works it will be the biggest breakthrough in HT's ever. Trust me even guys with limited donor will be able to have great transformations by moving more grafts than ever before.And more importantly you can use them all in the centre and in the front and buzz the crown along with the sides with NO scarring! You just have to be creative in hairstyles, i am sure a military crewcut will look better in most that the total shave!
Of course there won't be no hair were extracted but if you SMP there(unlike in the hairline that people do it now) you can cover the lack of density and look great. you can't add SMP to the little scars of FUE now...Comment
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To be honest Scarless FUE is nonsense. I got your stock standard FUE of 2100 grafts and at 7 days nobody would have any clue I'd had anything done if you we're only looking at my donor. At 10 days you couldn't tell I had anything done full stop.
This whole no scarring thing really doesn't seem like a big deal to me. I know for myself personally I have a tiny amount of scarring if I razor shave - Something I can see if I look closely but no-one else notices.
At a number 1 - Any scarring via FUE (That I've had) is invisible. I can search for up to 5 minutes and find nothing.
For what is such a small cosmetic difference in comparison to FUE; I wish their attention would be focused on increasing the donor.Comment
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Desmond - sorry to hijack. How's your Fin usage coming along? keep asking, you keep ignoring.. Thanks
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Hey JCM
I've now been taking 0.25 mg of fin for 20 months. My hair loss has completely stopped and my temples have filled in a little bit. All sides are gone except for morning wood not being there on some days hope that helps.
PS. I always replied. It's just that my posts must be read by a moderator first and by the time it gets displayed we are 1-2 pages past my post lol. Hope you see this one
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Hairbane, can I make a point here? Is there any possibility that Nigam isn't as bad a guy as his critics say he is? Is there any chance that he doesn't brag and embellish his greatness any worse than the other hair doctors out there? Aren't virtually all hair doctors out there exaggerating some what? Aren't they all embellishing? Aren't they all putting their best results out in front?
I ask because once cell therapy can "cure" hair loss it might be best to consider Nigam, or a doctor like him in India, so that we can possibly get the treatment sooner than waiting for the rest of the world to make it available.
Can I point something out without everybody screaming that I'm a Nigam-apologist and getting all po'd? Maybe Nigam was just doing questionable things because he was unable to "cure" hair loss with the knowledge that he's had to this point.
Basically, Nigam springboards off the knowledge major scientists have publicized so that limits the amount of hair growth Nigam can achieve. He can only achieve the amount of hair growth that is made possible by the information major scientists release. AND since the amount of regrowth he could achieve has been limited (by what major scientists publicized) doesn't that leave open the possibility that if the major scientists publicized enough information that he could actually get great regrowth then maybe he might stop doing things that are questionable.
In other words, maybe Nigam has only done questionable things because he didn't have the ability to give the great regrowth that people want. But maybe if he did have the ability to give the great regrowth that people want he would cease all questionable activity.
After all, doesn't it seem that he would feel more pressure to do questionable stuff if he couldn't give people the regrowth that they want, but once he could give people the regrowth that they want then he might not have a reason to do questionable stuff?
In other words, everything that we're complaining about Nigam might be just because he was unable to give us what we want so he had to stretch and manipulate but once he can give us what we want then there would be no reason for that.
My point is that if the major scientists really do cure hair loss then perhaps we shouldn't rule out Nigam or guys like Nigam to get the treatment earlier. It just seems to me that if Nigam could give us what we want (full regrowth) then he would have a lot less reason to be gamey about the whole thing than if he couldn't give us full regrowth.
I'm just sayin'Comment
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Here's a optimistic paper published a few weeks ago in the Journal of Experimental Dermatology that was reassuring to say the least It seems that even the researchers believe that we are on the event horizon and the final steps are within our grasps. A great time to be following all of these breakthroughs.
At the dawn of hair research – testing the limits of hair follicle regeneration.
Maksim V. Plikus, PhD
Department of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, CA 92697, USA.
In the late 1960’s, tissue recombination studies by Roy Oliver on the model of rat vibrissae provided invaluable information about the morphogenetic properties of hair follicles. Now more than ever, the field is hopeful that a clinically reproducible procedure for cell-based hair regeneration is achievable. Highly inductive mesenchymal cells are thought to be the key ingredient necessary to achieve robust hair regeneration, and efforts are underway to develop protocols to improve the naturally low inductive properties of human dermal papilla cells. In this respect, the original studies by Oliver provide essential rodent research benchmarks, which current-day human studies should aim to reach.
The hair follicle has emerged as one of the leading experimental models for studying mechanisms of tissue regeneration in adult mammals. The hair growth cycle is a prominent physiological regenerative process, wherein each hair follicle cyclically transitions through complex phases of remodeling, each time producing a new hair shaft. In addition to physiological regeneration, hair follicles are able to regenerate after injury, such as following transection and even when dissociated into a single cell suspension. Indeed, dissociated epithelial and mesenchymal cells can effectively reassemble into new, fully functional hair follicles when recombined in vivo (1).
The latter cell-based reconstitution experiments generated considerable excitement that hair follicles can be multiplied from limited donor material by expanding epithelial and mesenchymal cells in vitro and then implanting them into the donor site, such as into scars or scalp skin of patients with androgenetic alopecia. Follow-up studies using human instead of mouse cells painted a more complex picture, wherein this high hair-inducing ability displayed by mouse dermal papilla cells is not readily replicated by human cells under similar experimental settings (2, 3).
There is an ongoing effort to try to overcome the low inductive potential of human dermal papilla cells and adapt cell-based hair reconstitution techniques into clinical settings. Only recently, conclusive evidence for the ability of human cells to reassemble into new functional hair follicles was provided (4-6). To achieve human hair reconstitution, Thangapazham et al. (5) and Higgins et al. (7) improved hair inducing properties of adult dermal papilla cells in vitro by placing them into dermal-epidermal composites or growing them in three-dimensional spheroid cultures, respectively.
As the field continues to edge closer toward developing clinically successful strategies for cell-based hair restoration, there is a growing need to better understand the signaling basis behind the inductive properties of hair follicle mesenchyme. However, it is only within the last couple of years that genetic tools have been made available to hair researchers to study the mesenchymal aspect of complex signaling interactions underlying hair follicle development and regeneration (8-10).
............He then goes on to talk about some groundbreaking work done in 1960s which showed the importance of Dermal papilla cells in hair regeneration and then follows on to say:
In the future, it will be particularly interesting to establish if the dermal sheath primarily acts as the niche for mesenchymal stem cells of the dermal papilla. In addition, the dermal sheath exerts important other functions, such as regulating the behavior of epithelial cells in the outer root sheath, including the downward bound migration of epithelial stem cell progeny during anagen, the active hair growth phase (19). Also, comparative gene expression profiling between hair-inducing lower and non-inducing upper dermal sheath cells should yield novel mesenchymal determinants of inductivity with practical application for boosting efficacy of human hair reconstitution assays.
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Using Dermal sheath cells as a niche to grow DP cells is a very new idea at least to me anyway. Very interesting stuff. He basically thinks we should dermal sheath act as a 'bed' for DP cells to lay on in order to maintain their hair induction properties. At least in vivo (in our scalp) that is how they are situated which makes sense at least in theory.
Big thumbs up
DESMOND! found a scienfitic journal revolving around hair/alopeciaComment
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Sure, if he proves he can replicate the studies effectively, he'll have half the forums flying over to get it done. And I'm sure he'll be one of the first to try it. But you have to consider the doubling failure, all the unethical practices, the shady behaviour, etc. Basically he has a hell of a long road to redemption, but I guarantee if he actually is the first doctor to offer genuinely effective hair growth injections outside of clinical trials, all will be forgiven and he'll have more rupees than he'll know what to do with. I just doubt he's competent enough, and if he is, it will take a lot of convincing and evidence before the forums fly over to his clinic.Comment
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Nigam is COMPLETELY beyond any form of redemption.Comment
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I don't want to go out for a pint with the man, but I'm not in this to make friends, I just want hair to grow out of my scalp. So whoever figures out how to do it first will have my and many other peoples business, regardless of whether you dislike them. I'm 99.9% sure he's not capable of replicating the trial protocols though. That's why I think we should be looking for more reputable clinics/biologists/doctors in India who might have a decent chance of doing it if the protocol becomes available soon.Comment
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Hellouser, if we try to get a western doctor to open a clinic in India that means we have to accomplish 2 things:
1. Convince a western doctor to relocate to India.
2. Get him to start treatments early.
Obviously if we get an Indian doctor to do treatments early then we only have to accomplish one of those things. It's simply easier if we try to get an Indian doctor to do treatments early.Comment
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