George Cotsarelis and upenn new article today

[Scientalk56]

They could go on for another 1,000 years with breakthroughs.... they still haven't produced shit. Until all of us are able to actually take advantage of one of their 'breakthroughs' they haven't got any REAL results.

At some point after waiting for so long, you need to draw the line... a decade is a joke. How much longer should any of us tolerate more of the same old song and dance from these guys.. or any other researcher shill?

It's interesting to discuss studies and breakthroughs about hair loss, but we have to be realistic, it's not coming any time soon. It's not pessimism, it's just being honest with ourselves.

So, yes, you are right..

[hellouser]

A lot actually, read the research papers. Those are breakthroughs, and they have been trying to bring them to market for us. Being mad at them for not having been able to do so by now is illogical.

They could go on for another 1,000 years with breakthroughs.... they still haven't produced shit. Until all of us are able to actually take advantage of one of their 'breakthroughs' they haven't got any REAL results.

At some point after waiting for so long, you need to draw the line... a decade is a joke. How much longer should any of us tolerate more of the same old song and dance from these guys.. or any other researcher shill?

[UK_]

Whatever happened with Aderans it used to be all anyone talked about and hyped it to no end.

Their protocol was garbage, it didnt create decent hair (just a few invisible whiskers) and the investors put an end to a decade long clinical trial... people were waiting since 2003 to have their hopes dashed in the space of a few weeks.

Thats the hair loss industry for you, it's one big pile of puke on a rotting corpse.

Aderans = Intercytex

^^There were some individuals on hair loss forums who predicted this would happen many moons ago.

The 3D spheroid angle looks promising, it's all about having a 3D scaffold for the cells to multiply in an environment where the environment communicates to the cells what the cells need to do (i.e. turn into hair follicles)... that's evolutionary biology 101... the only issue is now we have to wait another 15 - 2000 years for all the trials and bullshit before we get a decent treatment (if we ever get one).

[burtandernie]

Whatever happened with Aderans it used to be all anyone talked about and hyped it to no end.

[UK_]

A lot actually, read the research papers. Those are breakthroughs, and they have been trying to bring them to market for us. Being mad at them for not having been able to do so by now is illogical.

Ugh. They've produced nothing but false promises from behind those closed doors at upen, and they'll just end up like Aderans within two years time.

[Thinning87]

Here's another perspective:

Dr. Cotsarelis has been working on a cure/treatment for hair loss for about a decade. Follica included.

What do they have to show after all this time?

A lot actually, read the research papers. Those are breakthroughs, and they have been trying to bring them to market for us. Being mad at them for not having been able to do so by now is illogical.

[Kiwi]

Here's another perspective:

Dr. Cotsarelis has been working on a cure/treatment for hair loss for about a decade. Follica included.

What do they have to show after all this time?

Boom! Nadda!

I think the Israeli stuff seems the most promising for 2014 :-/

[BDDFreak]

Here's another perspective:

Dr. Cotsarelis has been working on a cure/treatment for hair loss for about a decade. Follica included.

What do they have to show after all this time?

Lol I wish there was a company who had all bald/balding employees working on a cure. The incentive factor alone would get us the cure in no time. I'm with u man. They should have a viable treatment by now, but it's also good to remember they don't owe us anything. We haven't personally invested in their product (unless u have then im extremely sorry). Whatever they're working on still seems to have financial backing as far as investors go so there has to be something there for them to show. It's just a matter of when.

Honestly though putting all frustration aside, I can't say I'm mad even if they are just beating around the bush and trying to keep their research position because everyone just trying to eat. They have families I'm sure they have to provide for. But I'm sure they also understand how much money they'd be rolling in if they did bring a cure to light.

[hellouser]

As I'm about to go in the shower to get ready for tonight I have a thought about Follica I wanted to share.

I think they might be closer than all us pessimists believe. Reading more into what they are doing, it seems like by now they are testing fgf9 in preclinical and, if successful, they will go to human clinical trials with it. It's been six months since their article actually, so potentially they already have a good idea.

Anyways, it seems like even without fgf9 they had a pretty good idea of how to "consistently" create follicles. It was just a matter of producing a result that was cosmetically significant, and fgf9 seems to be the key to this.

But the fact that they have been able to create new follicles consistently is extremely positive because it shows an understanding of the genesis process. All they need to do now is figure out protocols to efficiently yield significant results that people will pay for, or in other words, a full head of hair.

The investigation has therefore turned to proteins and molecular pathways to up regulate follicular genesis from wounding. As I understand, for how complex it might be, it seems to me like it's only a waiting game until they can find the right combination of proteins to up/down regulate in order to achieve the results we dream of. A waiting game because there is only a finite number of these potential pathways that need to be investigated, for how complex it might be to do so.

This, in perspective, is huge.

Here's another perspective:

Dr. Cotsarelis has been working on a cure/treatment for hair loss for about a decade. Follica included.

What do they have to show after all this time?

[Thinning87]

As I'm about to go in the shower to get ready for tonight I have a thought about Follica I wanted to share.

I think they might be closer than all us pessimists believe. Reading more into what they are doing, it seems like by now they are testing fgf9 in preclinical and, if successful, they will go to human clinical trials with it. It's been six months since their article actually, so potentially they already have a good idea.

Anyways, it seems like even without fgf9 they had a pretty good idea of how to "consistently" create follicles. It was just a matter of producing a result that was cosmetically significant, and fgf9 seems to be the key to this.

But the fact that they have been able to create new follicles consistently is extremely positive because it shows an understanding of the genesis process. All they need to do now is figure out protocols to efficiently yield significant results that people will pay for, or in other words, a full head of hair.

The investigation has therefore turned to proteins and molecular pathways to up regulate follicular genesis from wounding. As I understand, for how complex it might be, it seems to me like it's only a waiting game until they can find the right combination of proteins to up/down regulate in order to achieve the results we dream of. A waiting game because there is only a finite number of these potential pathways that need to be investigated, for how complex it might be to do so.

This, in perspective, is huge.

[Hicks]

If you need 1500 graphs go get 800-1000 to feed the beast. Yes the medical system is crap but what else is there?

[strife91]

I feel for u hell, my quality of life has gone to shit from this bs.

[greatjob!]

I have my good weeks and then I have my bad weeks. Sometimes I feel like my hair is doing better and this feeling lasts for a while and then other times when I see myself in the mirror I feel its doing terrible. Those emotions can change rapidly; today I'll feel like my hair has improved with my regimen, the next I'll feel like shit thinking its going down the crapper.

I'm not talking to anyone except for people on the hair loss forums. Why? Because doctor's couldn't give a single shit about you. My mom nearly destroyed her knee last year, her doc kept her waiting with MRI's and advice for months and DISREGARGED physiotheraphy. She's got TWO torn ACL's, torn meniscus, one torn MCL and damaged cartilage. It took her THREE visits over three months and begging to get sent to a specialist. Previously it took 4 months to get an MRI. The system in Canada is bullshit. And given that everyone sees hair loss as a chance for mockery and self superiority, talking to someone WILL make matters worse. You think you or I will get any sympathy out of this? You think any of their meaningless crap they spew out at me will give me hair or anything? They're paid to do that. If my money is going ANYWHERE it will be for hair.... ONLY.

Anyway, I'm *somewhat* lucky. Here's why: Apart from my hairline, you can't tell I have hair loss. I specifically asked my hair stylist to try and differentiate my hair at the top from the back and sides, she said she couldn't really tell much of a difference in terms of density. Where I am now, its basically taken me about 7-10 years to reach and visually hasn't got much worse in the last 4-6 years. I could easily go in for a simple 1,400-1,800 graft hair transplant and get back down to a SOCIALLY TOLERABLE NW2 level. I say socially tolerable, because most, if not damn near all people privileged to HAVE hair, subconsciously have GIMPED those without. THATS why I'm so pissed off. I'm TIRED of feeling as if I'm always on the shit end of the stick. I've got other issues too but I'm not going to get into them. Essentially my life's been one struggle after another. Nothing seems to work out for me.

I have the money to drop on an HT, but given FUT's long stupid scar at the back, FUE's moth eaten scars and Dr Gho's dubious claims of 85% regeneration (yet still limiting his patients to three maximum procedures?! DAFUQ?!)... I'm hesitant to do it. If any HT is going to be a necessity for me, I'm more likely to go with Dr. Wesley and see how HIS claims of regeneration pan out.

This disease is long overdue for a cure. PERIOD. There's no excuse for the stage we're at one month away from 2014.

If you think you're on the "shit end of the stick" try loosing your hair when you're 12 years old. I reached your level of loss when I was in high school.

[hiilikeyourbeard]

I have my good weeks and then I have my bad weeks. Sometimes I feel like my hair is doing better and this feeling lasts for a while and then other times when I see myself in the mirror I feel its doing terrible. Those emotions can change rapidly; today I'll feel like my hair has improved with my regimen, the next I'll feel like shit thinking its going down the crapper.

I'm not talking to anyone except for people on the hair loss forums. Why? Because doctor's couldn't give a single shit about you. My mom nearly destroyed her knee last year, her doc kept her waiting with MRI's and advice for months and DISREGARGED physiotheraphy. She's got TWO torn ACL's, torn meniscus, one torn MCL and damaged cartilage. It took her THREE visits over three months and begging to get sent to a specialist. Previously it took 4 months to get an MRI. The system in Canada is bullshit. And given that everyone sees hair loss as a chance for mockery and self superiority, talking to someone WILL make matters worse. You think you or I will get any sympathy out of this? You think any of their meaningless crap they spew out at me will give me hair or anything? They're paid to do that. If my money is going ANYWHERE it will be for hair.... ONLY.

Anyway, I'm *somewhat* lucky. Here's why: Apart from my hairline, you can't tell I have hair loss. I specifically asked my hair stylist to try and differentiate my hair at the top from the back and sides, she said she couldn't really tell much of a difference in terms of density. Where I am now, its basically taken me about 7-10 years to reach and visually hasn't got much worse in the last 4-6 years. I could easily go in for a simple 1,400-1,800 graft hair transplant and get back down to a SOCIALLY TOLERABLE NW2 level. I say socially tolerable, because most, if not damn near all people privileged to HAVE hair, subconsciously have GIMPED those without. THATS why I'm so pissed off. I'm TIRED of feeling as if I'm always on the shit end of the stick. I've got other issues too but I'm not going to get into them. Essentially my life's been one struggle after another. Nothing seems to work out for me.

I have the money to drop on an HT, but given FUT's long stupid scar at the back, FUE's moth eaten scars and Dr Gho's dubious claims of 85% regeneration (yet still limiting his patients to three maximum procedures?! DAFUQ?!)... I'm hesitant to do it. If any HT is going to be a necessity for me, I'm more likely to go with Dr. Wesley and see how HIS claims of regeneration pan out.

This disease is long overdue for a cure. PERIOD. There's no excuse for the stage we're at one month away from 2014.

god this hits home for me

i'm so sorry we all have to go through this.

[hellouser]

It makes me sad to see how all this is getting to you man. It seems you're getting more and more depressed. We all hate baldness and we're all frustrated with the slow progress to some extend but it shouldn't effect your daily wellbeing that much. I'm no psychiatrist but I think you should ask yourself: what difference will a full head of hair make and are there other ways to attain those goals ? Cause honestly, we're years from a cure man. I really think you should go talk to someone, your doctor for example. Nobody needs to suffer like you seem to do from getting bald. There's so much more in life. Good luck man, I really wish you all the best

I have my good weeks and then I have my bad weeks. Sometimes I feel like my hair is doing better and this feeling lasts for a while and then other times when I see myself in the mirror I feel its doing terrible. Those emotions can change rapidly; today I'll feel like my hair has improved with my regimen, the next I'll feel like shit thinking its going down the crapper.

I'm not talking to anyone except for people on the hair loss forums. Why? Because doctor's couldn't give a single shit about you. My mom nearly destroyed her knee last year, her doc kept her waiting with MRI's and advice for months and DISREGARGED physiotheraphy. She's got TWO torn ACL's, torn meniscus, one torn MCL and damaged cartilage. It took her THREE visits over three months and begging to get sent to a specialist. Previously it took 4 months to get an MRI. The system in Canada is bullshit. And given that everyone sees hair loss as a chance for mockery and self superiority, talking to someone WILL make matters worse. You think you or I will get any sympathy out of this? You think any of their meaningless crap they spew out at me will give me hair or anything? They're paid to do that. If my money is going ANYWHERE it will be for hair.... ONLY.

Anyway, I'm *somewhat* lucky. Here's why: Apart from my hairline, you can't tell I have hair loss. I specifically asked my hair stylist to try and differentiate my hair at the top from the back and sides, she said she couldn't really tell much of a difference in terms of density. Where I am now, its basically taken me about 7-10 years to reach and visually hasn't got much worse in the last 4-6 years. I could easily go in for a simple 1,400-1,800 graft hair transplant and get back down to a SOCIALLY TOLERABLE NW2 level. I say socially tolerable, because most, if not damn near all people privileged to HAVE hair, subconsciously have GIMPED those without. THATS why I'm so pissed off. I'm TIRED of feeling as if I'm always on the shit end of the stick. I've got other issues too but I'm not going to get into them. Essentially my life's been one struggle after another. Nothing seems to work out for me.

I have the money to drop on an HT, but given FUT's long stupid scar at the back, FUE's moth eaten scars and Dr Gho's dubious claims of 85% regeneration (yet still limiting his patients to three maximum procedures?! DAFUQ?!)... I'm hesitant to do it. If any HT is going to be a necessity for me, I'm more likely to go with Dr. Wesley and see how HIS claims of regeneration pan out.

This disease is long overdue for a cure. PERIOD. There's no excuse for the stage we're at one month away from 2014.