George Cotsarelis and upenn new article today

[DepressedByHairLoss]

Whoop de do. Big f****n deal. Scientists have known since the late-90's the stimulation of the WNT and beta catenin pathways have stimulated hair growth in mice. This latest thing is just restating what other scientists have been restating over and over again for years.

[HairlossAt15]

Where can I find the paper?

[Sogeking]

Isn't histogen's HSC also based on wnt-something? I'm not much of an expert in the field

I just wanted to post this. Basically HSC has folistatin, KEGF , VEGF (the last two are growth factors) and Wtn7a,. Now check the title of these study they say that they removed the inhibitor Dkk1 in order to make hair follicle proliferation better. The real question is if we actually remove Dkk1 inhibitor while applying HSC would that give us even better results.

Next point worth analyzing, at least for me, would be if the velus hair that people seem to get while dermaroling would actually benefit from this additional hair follicle proliferation by inhibiting Dkk1?

Are there any safe compounds or natural based "remedies" which can inhibit Dkk1?

Dr. Cotsarelis is doing basic long term research it is up to Follica to patent something and try to apply it in economical, feasible effective way as a treatment. But as we all know Follica is not in a hurry obviously...

And in the end I see this is a mostly beneficial type of a treatment in order to replace waxing, and too much hair on people...

[Thinning87]

Isn't histogen's HSC also based on wnt-something? I'm not much of an expert in the field

[Morbo]

The only thing I get from this article is the word 'could'.
On a long term one of those thousand hypothesis about hair loss released each year should (or 'could') lead to a solution but on a short term I wouldn't lose my sleep over it. It just confirms the fact that there is still so much about hairloss that we still don't know.

[hellouser]

ive been researching threads on follica and true hair multiplication and seeing people say "I'm just gonna stay on fin and hope it gets me through another 5 years until follica (or HM) comes out" and then I look at the posting date and it says 2007-2008. It really is quite ridiculous how we've been on repeat for years

7 god damn years for these biotechs to just SCREW with people. Disgusting.

[mmmcoffee]

ive been researching threads on follica and true hair multiplication and seeing people say "I'm just gonna stay on fin and hope it gets me through another 5 years until follica (or HM) comes out" and then I look at the posting date and it says 2007-2008. It really is quite ridiculous how we've been on repeat for years

[deuce]

we should have something now rather than continuously waiting. Everyones made a complete mockery out of the cure for baldness.

+1000

[hellouser]

Oh wow I didn't realize that. Well the more people working on the cure, the better. We will have something sooner or later boys.

We should have something now rather than continuously waiting. Everyones made a complete mockery out of the cure for baldness.

[FearTheLoss]

That's Follica. Upenn is separate.

Oh wow I didn't realize that. Well the more people working on the cure, the better. We will have something sooner or later boys.

[hellouser]

so does this mean they gave up on FGF9 and wounding?

That's Follica. Upenn is separate.

[Dan26]

proteasome inhibitors ie psi/mg132 tend to profilerate and induce b-catenin/wnt pathway

we know the patent checks out (proteasome inhibitors hair growth effect) and there is limited trial data from psi which isn't super encouraging, but was a very short time frame and small amount and created TERMINAL hairs (albeit a small #) but to increase terminal hairs in such a time frame it it is clear it acts on an important/unique pathway

[FearTheLoss]

so does this mean they gave up on FGF9 and wounding?

[burtandernie]

If they dropped everything and started a treatment with this your talking what 5+ years bare minimum? Add at least a few years for better understanding of this pathway if it works out and trying to find a way to intervene with the pathway safely. I hope it turns out to be a huge win though with regrowing hair but its many many years away like many other things just because of the time it takes to prove its safe.

[hellouser]

It seems to be many years away but they plan to push forward this line of investigation.
If successful, this is the type of cure i want.



Here is the link:

http://www.sciencenewsline.com/artic...523420087.html

You know, I think if you really wanted to give these guys incentive to release something quickly, you'd take away their salary, I mean funding.... oh wait, thats essentially the same thing.

This hair loss solution is taking WAY too long.