7th World Congress for Hair Research (2013)

[Arashi]

You're talking about a completely different strand of nanotechnology - clearly you dont understand the difference, I'm not expecting someone to inject me with finasteride and then have it delivered by a microscopic robot as a payload to each of my hair follicles. Jesus Christ.

Here is an interesting article that explains how it works and what nanoparticles are: http://www.medscape.com/viewarticle/770397

As you'll see, nanoparticles are not robots, but just 'structures' that can bind to a target. Also read page 5 to understand why it will take years before this will be approved and used for cosmetic drugs like fina (in summary, safety concerns + high costs)

[Arashi]

You're talking about a completely different strand of nanotechnology - clearly you dont understand the difference, I'm not expecting someone who inject me with finasteride and then have it delivered by a microscopic robot as a payload to each of my hair follicles. Jesus Christ.

I think you're confusing stuff. Nanoparticles are not robots. They're just a 'vehicle' that can bind to a certain target.

[UK_]

What do you mean ? The nano particles guide drug to a specific target and degrade there, releasing their load (fina in this case), to lower side effects of the drug. Not sure what you mean ?

You're talking about a completely different strand of nanotechnology - clearly you dont understand the difference, I'm not expecting someone to inject me with finasteride and then have it delivered by a microscopic robot as a payload to each of my hair follicles. Jesus Christ.

[Arashi]

Arashi,
Believe me, i am not talking about nano particulate delivery alone..but also iontophoresis and other mechanism of skin permeation to deliver and keep local concentrations of finasteride at the scalp...yes nano particulate will take time for it's biodegradable factor and permeation beyond into the tissues of dermis...

Ok. Anyway thanks for sharing info from the conference here, that's much appreciated and certainly nice to see you do that.

[Arashi]

The nanotech you're thinking of is the Star Trek whacko science.

The nanotech these biotechnology professionals are talking about are the same technology they currently use in a number of skin creams such as most famously sun lotion which reduces systemic absorbtion/side effects.

What do you mean ? The nano particles guide drug to a specific target and degrade there, releasing their load (fina in this case), to lower side effects of the drug. Not sure what you mean ?

[drnigams]

Arashi,
Believe me, i am not talking about nano particulate delivery alone..but also iontophoresis and other mechanism of skin permeation to deliver and keep local concentrations of finasteride at the scalp...yes nano particulate will take time for it's biodegradable factor and permeation beyond into the tissues of dermis...

As always, you're exaggerating things. Sure, nanoparticle assisted drug delivery is going to be one of the biggest pharma breakthroughs of this decennium but not 'soon' as in next year. Very interesting progress is currently being made, one of the biggest concerns of course was the toxicity of the particles, so bio-degradability is key and just yesterday this awesome news came out: http://www.sciencedaily.com/releases...0507115506.htm however research here is still pre-clinical. By the time nano particle assisted drug delivery is a main stream thing, we'll hopefully have a real cure like Team Tokyo's available as well.

[UK_]

As always, you're exaggerating things. Sure, nanoparticle assisted drug delivery is going to be one of the biggest pharma breakthroughs of this decennium but not 'soon' as in next year. Very interesting progress is currently being made, one of the biggest concerns of course was the toxicity of the particles, so bio-degradability is key and just yesterday this awesome news came out: http://www.sciencedaily.com/releases...0507115506.htm however research here is still pre-clinical. By the time nano particle assisted drug delivery is a main stream thing, we'll hopefully have a real cure like Team Tokyo's available as well.

The nanotech you're thinking of is the Star Trek whacko science.

The nanotech these biotechnology professionals are talking about are the same technology they currently use in a number of skin creams such as most famously sun lotion which reduces systemic absorbtion/side effects.

Whats the point?

[Arashi]

Pentarou,
1)The swiis/japanese company product manager approached me for mini clinical trial of their topical CG210 alone or in conjunction with oral or topical finasteride foam.They provided me with few samples.
Can only tell about it's efficacy after using the same.
2)P-3074 a topical 0.25%finasteride with special delivery vehicle called HYDROXYPROPYL CHITOSAN(HPCH),a film forming agent,with single daily topical dosage showed reduction in scalpDHT by 71.2% as against oral finasteride which showed reduction of scalp DHT by 51.1% with equal period of therapy.
With Annika Vogt coming up with nano particulate and virus like targetted delivery vehicles(to every aspect of follicle ,including stemcells)..oral finasteride will be in the grave yard soon..and it's systemic sexual side effects could be avoided.

As always, you're exaggerating things. Sure, nanoparticle assisted drug delivery is going to be one of the biggest pharma breakthroughs of this decennium but not 'soon' as in next year. Very interesting progress is currently being made, one of the biggest concerns of course was the toxicity, so bio-degradability is key and just yesterday this awesome news came out: http://www.sciencedaily.com/releases...0507115506.htm however research here is still pre-clinical. By the time nano particle assisted drug delivery is a main stream thing, we'll hopefully have a real cure like Team Tokyo's available as well.

Of course toxicity in case of fina load is not that much of an issue but still, if the biodegredability kinetics aren't right, it's not going to improve things

[TO YOUNG TO RETIRE]

Dr Nigam we really apreciate your effort,


we all thank you , we hope we ll talk about these in detail soon

[drnigams]

Pentarou,
1)The swiis/japanese company product manager approached me for mini clinical trial of their topical CG210 alone or in conjunction with oral or topical finasteride foam.They provided me with few samples.
Can only tell about it's efficacy after using the same.
2)P-3074 a topical 0.25%finasteride with special delivery vehicle called HYDROXYPROPYL CHITOSAN(HPCH),a film forming agent,with single daily topical dosage showed reduction in scalpDHT by 71.2% as against oral finasteride which showed reduction of scalp DHT by 51.1% with equal period of therapy.
With Annika Vogt coming up with nano particulate and virus like targetted delivery vehicles(to every aspect of follicle ,including stemcells)..oral finasteride will be in the grave yard soon..and it's systemic sexual side effects could be avoided.

Dr Nigam, has there been any signs at the congress that any business attending is likely to launch any new anti-hairloss products, however minor, in the next 5 years or less?

[UK_]

Hey, you stole my line!

mahahaha yeah I thought it was a good post (nice to see some common sense for a change) thought 2 forums would be better than one.

[Dazza]

Hey, you stole my line!

lol, at least hes not quoting from jarjar..

[oppenheimer82]

Dr Nigam will be meeting with Histogen on the 11th May - hopefully we can find out if Dr Nigam can get hold of some kind of license off Histogen to offer HSC in his clinic?

Hey, you stole my line!

[Vox]

Also, poster 448 (Full-thickness skin with mature and cycling hair follicles using tissue culture expanded human cells) looks very interesting. Isn't that more or less what Histogen is trying to do?

[UK_]

Dr Nigam will be meeting with Histogen on the 11th May - hopefully we can find out if Dr Nigam can get hold of some kind of license off Histogen to offer HSC in his clinic?