It 's over. Dr. Mwamba confirmed Nigam!

[Dan26]

The champ is here!

[gc83uk]

Splitting FU's (like HASCI seems to do, so 1x2 FU = 2x1FU) is of course not doubling, you don't end up with more hair. So Mwamba must be talking about extracting a 2 FU, split it and generate 4 hairs in recipient and then re-grow that 2 FU in donor with the cultured cells.

2 to 6 hairs wow, doubling is so yesterday!

[Arashi]

Sounds incredible when put like that.

Or like Spencer puts it "It's amazing ... it's amazing ... it sounds like science fiction at this point". Hehe. Let's all hope this is true ... It surely gets my hopes up !

[didi]

DENOVO technique there is no tansecting.bisecting of graft as there is in INVITRO?

[gc83uk]

Mwamba says he's most probably not going to do InVivo. He's going to experiment with Invitro (and the way I understood it, you can do that in Europe, and it's effectively donor doubling) and with de-novo and that could be called something like donor-trippling ? It regenerates donor with the cells and then both halves go into recipient.

Sounds incredible when put like that.

I can't think why he wouldn't try Invivo, I guess he is worried about it being blind whereas the invitro is of course under the microscope.

[Arashi]

OK so bisect the follicle and place both parts in the recipient. Any idea why he would do this to start with? I take it this doesn't mean split a 2 FU into 2 x singles and place them in the recipient.... more like you get 2 x 2FU's in the recipient?

AND.... the donor regens by doing 2d/3d culture? I don't even understand that yet.

Splitting FU's (like HASCI seems to do, so 1x2 FU = 2x1FU) is of course not doubling, you don't end up with more hair. So Mwamba must be talking about extracting a 2 FU, split it and generate 4 hairs in recipient and then re-grow that 2 FU in donor with the cultured cells.

[gc83uk]

I hadn't even understood it but in the end of the interview Mwamba says that the de-novo method is about extracting the whole follicle, split it, inject both halves into recipient and then use the 2d/3d culture etc to regenerate donor ! Wow ... If that works ... just wow ...

It's hard not to get overly excited cause all this is exactly what we want to hear But fact remains, we don't know if it works, Mwamba says he doesn't know and both Spencer and Mwamba hint that it might take at least a year before we know ...

OK so bisect the follicle and place both parts in the recipient. Any idea why he would do this to start with? I take it this doesn't mean split a 2 FU into 2 x singles and place them in the recipient.... more like you get 2 x 2FU's in the recipient?

AND.... the donor regens by doing 2d/3d culture? I don't even understand that yet.

[Arashi]

Does that make sense to you?

To me that means extract whole graft out of donor, just as we do with FUE and implant in the recipient.

The regen of donor is down to stemcells etc, so this is kind of what I was asking before, can Mwamba do that in Europe or would you need to fly to Mumbai for that part?

Mwamba says he's most probably not going to do InVivo. He's going to experiment with Invitro (and the way I understood it, you can do that in Europe, and it's effectively donor doubling) and with de-novo and that could be called something like donor-trippling ? It regenerates donor with the cells and then both halves go into recipient.

[gc83uk]

This is how Nigams put it himself a few pages back in this thread:

by extracting out, most of the graft like fue..as in de-novo.. is also safe...since like fue ,recipient will grow back(as we take most of the intact graft in de novo doubling like fue...
(in denovo doubling we regenerate donor with multiplied stemcells,growth factors and 2d/3d dp culture cells,as the donor is non aga scalp..and have good density even around extracted grafts).

Does that make sense to you?

To me that means extract whole graft out of donor, just as we do with FUE and implant in the recipient.

The regen of donor is down to stemcells etc, so this is kind of what I was asking before, can Mwamba do that in Europe or would you need to fly to Mumbai for that part?

[Arashi]

I hadn't even understood it but in the end of the interview Mwamba says that the de-novo method is about extracting the whole follicle, split it, inject both halves into recipient and then use the 2d/3d culture etc to regenerate donor ! Wow ... If that works ... just wow ...

It's hard not to get overly excited cause all this is exactly what we want to hear But fact remains, we don't know if it works, Mwamba says he doesn't know and both Spencer and Mwamba hint that it might take at least a year before we know ...

[Arashi]

You couldn't explain the donovo in a couple of sentences could you please?

I know I've read it somewhere, but it was explained alongside a myriad of other options, so it wasn't memorable at the time.

Does he not need ECM?

This is how Nigams put it himself a few pages back in this thread:

by extracting out, most of the graft like fue..as in de-novo.. is also safe...since like fue ,recipient will grow back(as we take most of the intact graft in de novo doubling like fue...
(in denovo doubling we regenerate donor with multiplied stemcells,growth factors and 2d/3d dp culture cells,as the donor is non aga scalp..and have good density even around extracted grafts).

[gc83uk]

What I understand from the interview that only the 'denovo' surgery (so including the cells+growthfactors) would get 100% regrowth.

You couldn't explain the donovo in a couple of sentences could you please?

I know I've read it somewhere, but it was explained alongside a myriad of other options, so it wasn't memorable at the time.

Does he not need ECM?

[Arashi]

OK well that's a conversation for maybe a few weeks time, probably not clever to consider it whilst 1 week post op from my current HST. I'm impatient as you have probably noticed, so it wouldn't be like me to not do it.

On to Mwamba, am I right in thinking that the Doubling still needs HM + ECM + progenitor cells? I noticed Nigam said Mwamba clients would have to fly to India to finish off the whole course of treatment. Do you know anything about that?

What I understand from the interview that only the 'denovo' surgery (so including the cells+growthfactors) would get 100% regrowth.

[Arashi]

if this is all true Dr Nigam is will become a saint in hair loss world, I just wish he came to the scene 10 years earlier
its almost 2014 and strip is still a golden standard

Like Spencer put it: "he's either extremely confident or out of his mind" I think that pretty much sums it up. Nigams is either going to turn out to be a hero or a nutcase. And we'll know about that in a few months.

[gc83uk]

It's a very long trip for me, living in the Caribbean. But really, if you want to go, I'd be happy to pay for that ticket + couple hotel nights ! But only when you go soon of course, otherwise I'll just wait for Mwamba's results. But it would be extremely interesting to monitor your case man !! And if it works, I'll go myself there ASAP, probably to Mwamba in Belgium though.

OK well that's a conversation for maybe a few weeks time, probably not clever to consider it whilst 1 week post op from my current HST. I'm impatient as you have probably noticed, so it wouldn't be like me to not do it.

On to Mwamba, am I right in thinking that the Doubling still needs HM + ECM + progenitor cells? I noticed Nigam said Mwamba clients would have to fly to India to finish off the whole course of treatment. Do you know anything about that?