Histogen at the ISHRS conference

[FearTheLoss]

Holy crap you're right!
http://www.mistressvenom.com/

hahahha kiwi you are killing me!

and I would back you up Kiwi, I would pay a few thousand for a guaranteed stop to my hairloss.

[Kiwi]

yes there is a market for everything... some people are willing to pay money for someone to shit on their face... one of those doesn't involve $100m+ initial investment.

Holy crap you're right!

http://www.mistressvenom.com/

[mjolnir]

2020 you seem like someone who has done there research and is a veteran in this field...what is your take on histogen right now? Aren't they at the point where it would be very unexpected that they fail?

Dude, don't ask 2020 - he's irrational and overly pessimistic, and for someone who's barely even lost any hair (I think he said he was a NW2), he gets WAY more upset about this stuff than is healthy. Histogen is only going to fail at this point if there are health concerns that haven't yet expressed themselves for the dosages and/or time frames of the current trials.

[FearTheLoss]

you people need to stop thinking in those terms. Very few percentages of people actually follow hair loss that closely and monitor their progress. 95% of people are like "yeah, I'm 40, and I have less hair than I did in my 20's... what can I do about it?" That's where HSC would step in by reversing the process.

2020 you seem like someone who has done there research and is a veteran in this field...what is your take on histogen right now? Aren't they at the point where it would be very unexpected that they fail?

[2020]

Cure: A number of injections that not only reverse balding but also prevents further loss.

you people need to stop thinking in those terms. Very few percentages of people actually follow hair loss that closely and monitor their progress. 95% of people are like "yeah, I'm 40, and I have less hair than I did in my 20's... what can I do about it?" That's where HSC would step in by reversing the process.

[2020]

At some point in your life specific genes switch on that tells your hair to start making more Androgen receptors. That's why some ppl bald in their 20's some in their 50's!

which genes are those? Yes, DHT is essential in the process but there is no way Aderans or Replicel are going to actually modify follicle DHT response. No way.

[2020]

I would be willing to pay thousands to maintain my hair and keep my dick in working order. Caus f*u*c*k Fin. So yes there is a target market. Me as well as anybody else with money will pay for that.

yes there is a market for everything... some people are willing to pay money for someone to shit on their face... one of those doesn't involve $100m+ initial investment.

Most people are way past the "comfortable" level of baldness. Also, what if I told you that women market share is much bigger than men's? Who is going to pay for zero results.

I pretty much agree about Histogen being our only real hope BUT I would like to say that I'm keeping an open mind about RU. Some people are posting good results... fingers crossed 2020!

RU? RU works, check HLH. If you don't trust RU then just buy CB which has actually been tested AND found to be more effective than fin... we're way past DHT blockers here. We need potent growth stimulants

[clarence]

Why don't you andyour new sidekick 2020 just clear off an leave the forum if you're so convinced there's nothing coming for another 10 - 15 years.

What? How? Well, for a sidekick, not only is 2020 rather unconvinced that HST works; he's had himself convinced that it's a load of bollocks, judging from his exclusive cultivation of hope in correspondence to Histogen.......

[neversaynever]

Cure: A number of injections that not only reverse balding but also prevents further loss.

There is no true cure in the near future, but there are treatments that many will consider 'as good as a cure'. Especially early to mid baldies.

It's just about perspective. Some people want that elusive silver bullet, so when they refer to Aderans, they expect total reversal of balding. Anything short of that is a failure. Aderans have some regrowth, but if its compoundable?

I think it's reasonable to expect the likes of Histogen to replace Minox. Though more expensive, saves the having to apply the skin drying, aging topical.

As for the DHT issue, jury is out, but there is at least hope. Guys who are nw1-2-3 maybe even 4 have plenty of reason to be optimistic.

If HSC works as they claim it works, then I am happy to have injections every 2-3-4-5 years. Whatever. I just want something to replace anti-androgens and minox, and for people with plenty of hair remaining, Histogen might just be that replacement.

[534623]

Why don't you andyour new sidekick 2020 just clear off an leave the forum if you're so convinced there's nothing coming for another 10 - 15 years.

hmmm, it would be the same as if the whole stem cell researcher community on this planet would ban Sir Martin J. Evans, THE father of embryonic stem cells …

http://www.baldtruthtalk.com/showthread.php?t=10090

… just because he predicted recently "Only our grandchildren will benefit" from stem cell treatments.

[UK Boy]

It's exactly THIS factor (and this factor is INSIDE the follicle), why you will not see a real useful "cure" in the coming 10-15 years - if at all.
And it's exactly THIS factor, which is extremely difficult (at least today) to reproduce.

And finally, it's exactly THIS factor, why you -without any doubts- will never ever see a real "cure" neither by Aderans, nor by Histogen.

You guys should bookmark this post - or I will do it for you - for future reference (in 10-15 years or so) ...

I don't get you Iron Man, I browsed your threads on Hairsite throughout 2012 and you and your mates kept telling everyone that Gho was the answer to all our problems and that once you'd had your procedure with Gho you would be getting on with your life enjoying your new hair. Instead you seem to have snuck your way back onto this forum and seem to be acting just as you always have - crapping on everyone else's optimism. Why don't you andyour new sidekick 2020 just clear off an leave the forum if you're so convinced there's nothing coming for another 10 - 15 years.

[534623]

I still feel there is one more factor, possibly outside the follicle, who knows.

It's exactly THIS factor (and this factor is INSIDE the follicle), why you will not see a real useful "cure" in the coming 10-15 years - if at all.
And it's exactly THIS factor, which is extremely difficult (at least today) to reproduce.

And finally, it's exactly THIS factor, why you -without any doubts- will never ever see a real "cure" neither by Aderans, nor by Histogen.

You guys should bookmark this post - or I will do it for you - for future reference (in 10-15 years or so) ...

[neversaynever]

Quite a few studies have confirmed that the androgen receptors on DP cells are the main culprit in degrading the communication between DP and stem cells, by altering the WNT, bmp (and other) pathways. It occurs until the communication completely stops (dormant follicle).

Logically, with Aderans, follicles are recruiting cells that have fewer androgen receptors. While we dont the the ratio of new cells / old cells that would save a balding follicle (cure), aderans have described they are taking steps to monitor the recruitment of new cells.

There is a chance the newly inducted dp cells might sprout more receptors, but theres also a chance they might not. I still feel there is one more factor, possibly outside the follicle, who knows.

I would stay hopeful. They are achieving regrowth for a reason. Besides, we'll know very soon if histogen and aderans will change the hair loss industry forever. If they both hit phase 3, I think we can be very excited. We're not looking at a real cure for slick nw6s, but I think the era of minox might be over soon. Hopefully fin too

[Desmond84]

bullshit. Not going to happen. This is such a simplistic view on this that it's painful to read... your follicles were "immune" to DHT(which has been there since puberty) before you started balding, are you aware of that?


Aderans and Replicel are finished. Everything else is 10+ years away. Histogen is our only hope.

Fact 1: The cure to hair loss does not have to be found. It is sitting on the back of your head.

Fact 2: DHT is by far the main culprit, hence why Finasteride is so powerful at halting hairloss.

Fact 3: Androgen receptors have only been found on TWO types of cells in the hair follicle: 1) Sebaceous glands 2) Dermal Papillae

Fact 4: Dermal Papillae play the most important role in controlling hair growth cycle and producing hair growth factors.

Fact 5: Dermal Papillae on the back of the head lack Androgen receptors whereas Dermal Papillae on the crown and temples express a large number of Androgen receptors.

Therefore, most plausible hypothesis would be:

"By transplanting Dermal Papillae that lack Androgen receptors, the remaining hairs will continue to grow indefinitely"

P.S. TWO points you didn't take into account:

a) DHT levels prior to puberty are miniscule to non-existent.

b) It is called Male PATTERN Baldness for a reason. Hair loss occurs in a pattern rather than all at once because Androgen receptors get expressed in high numbers in specific areas at a time (i.e. in the temples/crown) and then vertex, etc. Your hair follicles didn't always have so many Androgen receptors. At some point in your life specific genes switch on that tells your hair to start making more Androgen receptors. That's why some ppl bald in their 20's some in their 50's!

Aderans is definitely on the right track and ahead of everyone else in terms of releasing their product first!

Anyhow we'll know by Early May if Aderans is definitely going into Phase 3 or not...so let's be optimistic rather than sitting back and waiting for the world to end for all balding men and women!

The science is on Aderans' side...let's be positive

[clarence]

Aderans and Replicel are finished. Everything else is 10+ years away. Histogen is our only hope.

Looking at the pictures Histogen has so far provided, and considering the amount of documentation (despite the remaining inconclusiveness) that has been done about the HST, I'm surprised you put more hope into the lab rats. Already finished with the HST, while others are busy investigating it?