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"Pimecrolimus is a macrolactam of the immunosuppressant class. It is a selective inhibitor of pro-inflammatory cytokines and mediators in T cells and mast cells." (source: some website)
mast cells produce PGD2
"Conclusion: In conclusion, we detected that topical pimecrolimus treatment is as effective as topical corticosteroids and is superior to topical corticosteroids in terms of side effects in the treatment of AA."
source: http://informahealthcare.com/doi/abs...34.2011.590788
thusly, we should use pimecrollimusLeave a comment:
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Men with androgenic alopecia typically have higher levels of 5-alpha-reductase, lower levels of total testosterone, higher levels of unbound/free testosterone, and higher levels of total free androgens including DHT.[15][16]
Sex hormone-binding globulin (SHBG), which is responsible for binding testosterone and preventing its bioavailability and conversion to DHT, is typically lower in individuals with high DHT.WHY DID THIS THEORY DIE???The aim of this study was to evaluate the effect of supplementing healthy men with soy isoflavones on the serum levels of sex hormones implicated in prostate cancer development. A total of 28 Japanese healthy volunteers (18 equol producers and 10 equol non-producers) between 30 and 59 years of age were given soy isoflavones (60 mg daily) supplements for 3 months, and the changes in their sex hormone levels were investigated at the baseline and after administration. The serum and urine concentrations of daidzein, genistein, and the levels of equol in the fasting blood samples and 24-h stored urine samples were also measured. All 28 volunteers completed the 3-month supplementation with isoflavone. No changes in the serum levels of estradiol and total testosterone were detected after 3-month supplementation. The serum levels of sex hormone-binding globulin significantly increased, and the serum levels of free testosterone and dihydrotestosterone (DHT) decreased significantly after 3-month supplementation. Among the 10 equol non-producers, equol became detectable in the serum of two healthy volunteers after 3-month supplementation. This study revealed that short-term administration of soy isoflavones stimulated the production of serum equol and decreased the serum DHT level in Japanese healthy volunteers. These results suggest the possibility of converting equol non-producers to producers by prolonged and consistent soy isoflavones consumption.
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yes, betamethasone valeratel AND Clobetasol Propionate both have hypertrichosis as side effects
beta has been included in minox,we know it grows hair and could be the reason minox grows hair
but clobetasol has some AMAZING before/after pictures in that study I posted about AA and clobetasol and pimaminuuss-whatever
it's a toss up between the two. I think beta is the safer steroid of the two but I don't knowLeave a comment:
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like i said, no one wants to waste time and hair on something thats not scientifically proven.Leave a comment:
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what the hell?
Through the years, Mr. Murphy has always had an active interest in health and medicine, and he originally considered going to medical school. Instead, he decided to pursue his own specific interests, including nutritional supplements that he thought might help cure his early-stage androgenic alopecia. In 2008, after thousands of hours of research and development, he succeeded in creating a formula which halted his hair loss. After verification of his novel equol-producing formula from a third party laboratory, Mr. Murphy decided to turn his project into a business.
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