PGD2, betamethasone valeratel, and hair growth....

[2020]

dunno, no one wants to spend time (and hair) on something that possibly may or may not work, no one wants to fool around when hair is concerned theyd rather jump on "proven" treatments that are scientifically proven.

thats probably why it died out.

apparently equol is not available in its "equol form" and in order to start producing you would need to consume massive amounts of soy over a long period of time...
I can't believe no one has tried this equol approach

[NeedHairASAP]

The comparison of treatment with clobetasol propionate 0.05% and topical pimecrolimus 1% treatment in the treatment of alopecia areata

Read More: http://informahealthcare.com/doi/abs...34.2011.590788

this journal has crazy photos.. the before after pics are mind boggling... you google if and use google images you can see.. unfortunately you have to pay for the real article.\




also, pimecrolimus is a PGD2 antagonist and has less side affects than cortisolsteroids like clobetasol and betamethowhatever


another PGD2 antagonist is cetuximab.. but i think its an intense cancer drug



I think pimecrollimus is the way to go. We should test this out. I'm not seeing it mentioned that it has hair growth as a side effect

pimecrolimus works

http://webcache.googleusercontent.com/search?q=cache:aYPrzssR8hcJ:www.************/hair-loss/board_entry-id-37512-da-DESC-page-0-order-last_answer-descasc-DESC-category-1.html+pimecrolimus+hair+growth&cd=8&hl=en&ct=clnk&gl=us

http://webcache.googleusercontent.com/search?q=cache:vPVO4vkVFEYJ:forum.owndoc.com/showthread.php%3F859-Frontal-Fibrosing-Alopecia+pimecrolimus+hair+growth&cd=12&hl=en&ct=clnk&gl=us

http://webcache.googleusercontent.com/search?q=cache:pvPGFAfpzVMJ:www.****************/interact/viewtopic.php%3Ff%3D11%26t%3D19825%26p%3D167827+pimecrolimus+hair+growth&cd=14&hl=en&ct=clnk&gl=us

http://webcache.googleusercontent.com/search?q=cache:envae4Y-uN8J:www.hairloss-reversible.com/discus/messages/3/451.html%3F1288900726+pimecrolimus+hair+growth&cd=16&hl=en&ct=clnk&gl=us

The prolonged treatment with potent topical steroids deserves comment. Orentreich et al (4) reported the failure of local injections of corticosteroids to induce hair growth in 50 cases of male pattern alopecia. Topical corticosteroids were unsuccessful in 40 additional patients with various causes of alopecia (4). A restoration of the normal perifollicular vascular architecture accompanies both the spontaneous regrowth and corticosteroid-induced regrowth of hair in alopecia areata (5). It is possible that the prolonged use of a potent topical steroid induced a normalization of the vascular pattern, but this seems unlikely in view of the study of Orentreich et al (4).

Robert L. Rietschel, MD
David D. Madorsky, MD
Brooke Army Medical Center Fort Sam Houston, Tex

4. Orentreich N, Sturm HM, Weidman AI, et al: Local injection of steroids and hair growth in alopecias. Arch Dermatol 82:894-902, 1960.
5. Popchristov P, Konstantinov A, Obreshkova E: The blood vessels of the scalp in patients with alopecia areata before and after corticosteroid therapy. Br J Dermatol 80:753-757, 1968.

source:http://webcache.googleusercontent.co...&ct=clnk&gl=us

[gutted]

right okay but I see a bunch of threads from as early as 2004.... why did this thing die out? Why can't we come up with a theory, test it, and then declare it either true or false....

dunno, no one wants to spend time (and hair) on something that possibly may or may not work, no one wants to fool around when hair is concerned theyd rather jump on "proven" treatments that are scientifically proven.

thats probably why it died out.

[gutted]

The comparison of treatment with clobetasol propionate 0.05% and topical pimecrolimus 1% treatment in the treatment of alopecia areata

Read More: http://informahealthcare.com/doi/abs...34.2011.590788

this journal has crazy photos.. the before after pics are mind boggling... you google if and use google images you can see.. unfortunately you have to pay for the real article.\




also, pimecrolimus is a PGD2 antagonist and has less side affects than cortisolsteroids like clobetasol and betamethowhatever


another PGD2 antagonist is cetuximab.. but i think its an intense cancer drug



I think pimecrollimus is the way to go. We should test this out.

heres some more info - http://www.dermattikon.gr/magazines/...OULIS%20EN.pdf

i think its best to stick with the betamethasone valeratel.

we know hypertrichosis can be a side effect with that, with the rest of the stuff we're just guessing it could grow hair.

[NeedHairASAP]

The comparison of treatment with clobetasol propionate 0.05% and topical pimecrolimus 1% treatment in the treatment of alopecia areata

Read More: http://informahealthcare.com/doi/abs...34.2011.590788

this journal has crazy photos.. the before after pics are mind boggling... you google if and use google images you can see.. unfortunately you have to pay for the real article.\




also, pimecrolimus is a PGD2 antagonist and has less side affects than cortisolsteroids like clobetasol and betamethowhatever


another PGD2 antagonist is cetuximab.. but i think its an intense cancer drug



I think pimecrollimus is the way to go. We should test this out. I'm not seeing it mentioned that it has hair growth as a side effect

[2020]

eqoul binds to dht not pgd2??

right okay but I see a bunch of threads from as early as 2004.... why did this thing die out? Why can't we come up with a theory, test it, and then declare it either true or false....

[gutted]

and why not??? bald spots are bald because excessive PGD2 that is there prevents hair from growing. What would be the natural way to eliminate it then?

eqoul binds to dht not pgd2??

[NeedHairASAP]

how often were those guys in the AA study use it?

i dont think it says.

I'm not sure if it doesn't say



this guy used a bunch of shit, but it may have been his use of an EGFr inhibitor (not sure which) that caused the amazing regrowth (pictures in the hyperlinked thread).


I think there is some connections between EGFr and PGD2




we have to figure out if these foams stop PGD2. I know that both foams that I mention in the opening post have side affects of excessive hair growth...

[2020]

eqoul probably wont give you regrowth, rather help keep what you have.

and why not??? bald spots are bald because excessive PGD2 that is there prevents hair from growing. What would be the natural way to eliminate it then?

[gutted]

http://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=3692

Clinical Pharmacology

Like other topical corticosteroids, betamethasone valerate foam has anti-inflammatory, antipruritic, and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.

[gutted]

I know. I'm not sure how to go about it. Would it be okay to use it once a week? twice a week? I'm not sure how to find this out... i doubt my dermatoligist would be willing to help in a home hairloss experiment with his prescription.

how often were those guys in the AA study use it?

i dont think it says.

[bigentries]

If anyone is going to try this, please post a picture before starting treatment

[NeedHairASAP]

I got a bunch of test containers from my derm. Unfortunately not they are spurting liquid and no foam. I tried to shake them up but that didn't help either. The only way to get it is by prescription... I'm going to try to get a refill.

http://www.google.com/#hl=en&tbm=shop&sclient=psy-ab&q=betamethasone+valerate+foam&oq=betamethasone+valerate+foam&aq=f&aqi=g1&aql=&gs_l=serp.3..0.14590.15022.2.15139.5.2.0.0.0.0.481.481.4-1.1.0...0.0.W_giHGuVqJU&pbx=1&bav=on.2,or.r_gc.r_pw.r_qf.,cf.osb&fp=c09f4e041e2b4a90&biw=1191&bih=596

[NeedHairASAP]

http://www.************/hair-loss-in...amethasone.htm

it seems this has a bunch of minor side effects too

Side effects: Note that betamethasone is not intended for long term use. If corticosteroids are used long-term, There is the possibility of systemic absorption with corticosteroids and result inside effects such as skin thinning, a decrease in the production of natural hormones by the adrenal glands as well as a decrease in the production of collagen in our skin tissues. For this reason, continuous, long-term use of this medicine should be avoided wherever possible. Patients should avoid using betamethasone based hair products on a daily basis. Other side effects include:

dryness of the skin
acne
itching
burning
discoloration of the skin

I know. I'm not sure how to go about it. Would it be okay to use it once a week? twice a week? I'm not sure how to find this out... i doubt my dermatoligist would be willing to help in a home hairloss experiment with his prescription.

[gutted]

why aren't we shooting up with equal then?

eqoul probably wont give you regrowth, rather help keep what you have.