OC000459? (Yes that's its name)

[2020]

Hey 2020, how are you going to make it? What vehicle will you use and how will you mix it?

I'm not going to make it.... some offshore lab has started making it and it will be available soon.

[iHope]

I'm not going to make it.... some offshore lab has started making it and it will be available soon.

I hope I it'll have reasonable price.

[Gjm127]

Who figures out the doses and how frequently you gotta put it?

[2020]

I hope I it'll have reasonable price.

$80-$100 per gram. One gram will last about 2-3 months.

[iHope]

$80-$100 per gram. One gram will last about 2-3 months.

Nice... Gotta get myself a job! Thanks for info, you're awesome.

[neversaynever]

OC0459 blocks production of PGD2(protein responsible for shrinking follicles).

OC0459 is currently in Phase 2 for asthma and allergies. They won't market it for MPB because they can't. There is a patent filed in 2007 that prevents anyone from making a product that treats MPB by blocking PGD2.

Thats interesting...

Who holds the patent?

[2020]

Thats interesting...

Who holds the patent?

I know right... PGD2 and MPB connection was made at least 5 years ago so I'm not sure what Cotsarelis is waiting for...

http://www.google.com/patents/US20110021599

This invention provides methods of treating androgenetic alopecia (AGA), acne, rosacea, prostate cancer, and benign prostatic hypertrophy (BPH), comprising the step of contacting a subject with a compound or composition capable of decreasing prostaglandin D2 (PGD2) level or activity

Filing date: Jun 15, 2007

[hairysituation]

Nice to see someone being so passionate and proactive, brah. As a general hypothese, do you excpect this PGD2 to just slow/arrest your hair loss, or to actually reverse it?

[2020]

Nice to see someone being so passionate and proactive, brah. As a general hypothese, do you excpect this PGD2 to just slow/arrest your hair loss, or to actually reverse it?

I'm 99% sure that it can reverse all of your loss if you also combined it with PGE2 analog.... but the problem is that the effects will be temporary as with minox because it won't solve the real underlying problem which is DHT somehow disrupting prostaglandin balance in the first place

[Kirby_]

^ your hypothesis is that both in combination will even restore hair on areas that have been slick-bald for years?

Major bummer that this combo might have to be ongoing as with fin and minox. Still, if they turn out to work significantly better than those old dinosaurs, that will be something positive.

[Davey Jones]

I'm 99% sure that it can reverse all of your loss if you also combined it with PGE2 analog.... but the problem is that the effects will be temporary as with minox because it won't solve the real underlying problem which is DHT somehow disrupting prostaglandin balance in the first place

This is a bold statement, 2020. So in your opinion, OC000459 when combined with a PGE2 analog would totally cure for baldness (if applied regularly)? Are you in the process of trying this? And what is a PGE2 analog?

Sorry for the ignorance.

[Pate]

This is a bold statement, 2020. So in your opinion, OC000459 when combined with a PGE2 analog would totally cure for baldness (if applied regularly)? Are you in the process of trying this? And what is a PGE2 analog?

Sorry for the ignorance.

It's a bold and, to be honest, completely unjustified statement, nobody can honestly say they are 99% sure... but there is definitely a theoretical basis for believing that it could work extremely well, if baldness really is caused by unbalanced PGs.

An 'analog' in pharmacology is a molecule has the same effect as another molecule - usually meaning, a synthetic drug that has the same effect as a natural protein/enzyme/whatever. In this case meaning a drug that binds to the same receptors in the hair follicle as PGE2 does. PGE2 is one of the 'good' prostaglandins.

So you want a PGE2 analog and a PGD2 inhibitor. And the other PGs are in there too somewhere...

[hairysituation]

Maybe he can't be 99% certain that this PGD2-inhibitor could regrow hair, however I definitely respect this kind of proactivity. If it only arrest hair loss, it would still be a huge positive result. More power to 2020 and his passion!

[iHope]

In worst case scenario, it could give you extra years for your hair...

[Davey Jones]

So you want a PGE2 analog and a PGD2 inhibitor. And the other PGs are in there too somewhere...

Are there any obtainable compounds that act as PGE2? I'd love to see 2020 go through with it.

If it works like he thinks, 2020 will have hair (which is nice) and we will know of a way to restore our hair (which is really nice). That's assuming 2020 would come back to spread the gospel, but I think anyone who knows how hairloss can make life for us (which 2020 does) would come back (or never leave in the first place).

In worst case scenario, it could give you extra years for your hair...

Worst case scenario is (usually) that it does nothing at all, and then at very least he'll have weeded out one more thing that doesn't work.