OC000459? (Yes that's its name)

[gutted]

..... do you know WHY propecia lose its effectiveness? If you do, then that would answer your own question.

PGD2 blockers will NEVER EVER EVER EVER lose its effectiveness.

looool

10-char

[2020]

How is it obvious....explain it please. Id be extremely happy to see proof that DHT directly increases PGd2, or at least a good explanation...

in that study they said that testosterone and probably DHT affect ptgds which actually produces PGD2.
PGD2 is known to shrink follicles so that's a fact.
When a person is using DHT blockers, it's pretty obvious to assume to his PGD2 levels also go down a bit otherwise he wouldn't get any regrowth because of PGD2

[2020]

it'l lose effectiveness over time like propecia.

..... do you know WHY propecia lose its effectiveness? If you do, then that would answer your own question.

PGD2 blockers will NEVER EVER EVER EVER lose its effectiveness.

[neversaynever]

study that proves what? That DHT causes PGD2 to rise? There is no such study but it's pretty obvious that this happens...

How is it obvious....explain it please. Id be extremely happy to see proof that DHT directly increases PGd2, or at least a good explanation...

[gutted]

what do you mean by that?

it'l lose effectiveness over time like propecia.

[2020]

you cant remove pgd2 fully, it will eventually catchup with you.

what do you mean by that?

[gutted]

Can you point me to a study to prove that? Im not being hostile, just curious...

hers a study that might help explain why pgd2 remains upregulated in balding scalps

http://www.ncbi.nlm.nih.gov/pubmed/14632179

[2020]

Can you point me to a study to prove that? Im not being hostile, just curious...

study that proves what? That DHT causes PGD2 to rise? There is no such study but it's pretty obvious that this happens...

[gutted]

???

DHT -> high PGD2

remove PGD2

DHT -> NOTHING!

why would you even care about DHT?

you cant remove pgd2 fully, it will eventually catchup with you.

[neversaynever]

???

DHT -> high PGD2

remove PGD2

DHT -> NOTHING!

why would you even care about DHT?

Can you point me to a study to prove that? Im not being hostile, just curious...

[neversaynever]

i was thinking the same thing, its as if he had no desire to pursue this further which was strange to me too.

its likeley with these prostglandins the balance is always maintained, if one thing increases pge2 then this would have a knock on effect on pgd2 etc etc

dr cots probably knew its nothing more than super strength minoxidil.

I think if blocking pgd2 was a super next gen treatment, dr cots would have been all over it. It seems a big part of the puzzle, but theres still a missing piece.

Until we find the link between DHT and PG's and baldness....no cure.

Im more hopeful of a treatment that can save vellus, thin hairs and keeping terminal hairs. So far, that seems like histogen. I have a feeling allergen will have something too, before anyone else. They dont even need funding. But I do see a PGf2a section in dr cots patent, is that a problem for allergen?

I would LOVE to hear histogens opinions of PG levels. Dr Z has spoken of dr cots studies in a past interview, and that they keep an eye on new developments. I wonder if theyve tested PG levels in patients before and after HSC is applied?

[2020]

i meant your dht levels would still remain high increasing the pgd2, whilst you try and block pgd2, tug of war!

???

DHT -> high PGD2

remove PGD2

DHT -> NOTHING!

why would you even care about DHT?

[gutted]

and what would be the reason? Maybe his company - follica is working on some PGD2 stuff you never know



why would I increase DHT?

i meant your dht levels would still remain high increasing the pgd2, whilst you try and block pgd2, tug of war!

[gutted]

I dont get it. He has the knowledge, and the patent, so why no word on solutions? Hes passing the buck to other companies. I can only think because if a big pharma find an amazing treatment, theyll have to pay him royalties. Ive seen a video of him saying that there are a number of companies already testing pgd2 blockers (not for hair loss). This implies that he has no desire to provide the 'solution'.

Maybe he knows its not the silver bullet? Or maybe he knows it will be big and he will rake in millions in royalties?

Also, does anyone know the relationshp of pge2 and pgd2? Does pgd2 directly decrease the amount of pge2 in balding areas? If the pge2 levels are lower, regardless of pgd2 levels, then a pgd2 blocker is not enough really.

What about allergens treatment? Does dr cots mention pgf2a levels in balding areas?

i was thinking the same thing, its as if he had no desire to pursue this further which was strange to me too.

its likeley with these prostglandins the balance is always maintained, if one thing increases pge2 then this would have a knock on effect on pgd2 etc etc

dr cots probably knew its nothing more than super strength minoxidil.

[2020]

you need to look at the bigger picture, theres a reason why dr cots has been holding onto the patent since 2008...

and what would be the reason? Maybe his company - follica is working on some PGD2 stuff you never know

your going to block pgd2 on one hand and then increase dht on the other....i dont see it working...it'll probably provide results the same as minox and baldness will advance sureley but slowly.

why would I increase DHT?