OC000459? (Yes that's its name)

[neversaynever]

it's not assumed, it's a fact.

http://www.google.com/patents?id=MNTyAAAAEBAJ&zoom=4&dq=hair%20growth%20pgd2&pg=PA174#v=onepage&q&f=false

Page 78 - bottom right corner.

in a bald scalp there is 2x less PGE2 and more than 3x more PGD2.

If you created the same environment on a person who is "not prone to baldness", he would go bald nonetheless.

mice that were genetically engineered to lack PGD2 receptors were immune to baldness no matter what they've applied...

Dr cots holds the patent? for what exactly?

So, he releases the big news about pgd2 but holds a patent that would make him very rich if pgd2 treatments become the next generation of hair loss treatments? clever!

[neversaynever]

it's not assumed, it's a fact.

http://www.google.com/patents?id=MNTyAAAAEBAJ&zoom=4&dq=hair%20growth%20pgd2&pg=PA174#v=onepage&q&f=false

Page 78 - bottom right corner.

in a bald scalp there is 2x less PGE2 and more than 3x more PGD2.

If you created the same environment on a person who is "not prone to baldness", he would go bald nonetheless.

mice that were genetically engineered to lack PGD2 receptors were immune to baldness no matter what they've applied...

Assumed was the wrong word. But if we inhibit PGD2, how would we increase PGE2 to normal levels again?

[2020]

2020...

Is it assumed that there is an over production of PGD2 or under production of the good PGs?

Or is it receptors in follicles prone to MPB that gather the PGD2?

it's not assumed, it's a fact.

http://www.google.com/patents?id=MNTyAAAAEBAJ&zoom=4&dq=hair%20growth%20pgd2&pg=PA174#v=onepage&q&f=false

Page 78 - bottom right corner.

in a bald scalp there is 2x less PGE2 and more than 3x more PGD2.

If you created the same environment on a person who is "not prone to baldness", he would go bald nonetheless.

mice that were genetically engineered to lack PGD2 receptors were immune to baldness no matter what they've applied...

[neversaynever]

2020...

Is it assumed that there is an over production of PGD2 or under production of the good PGs?

Or is it receptors in follicles prone to MPB that gather the PGD2?

[youngsufferer]

I was really excited about replicel and they did nothing and had no backing evidence that their methods would even work. Now we're seeing all these studies on pdg2 and I can only hope that it's all correct and we're right around the corner from the actual cure. If inhibiting pdg2 doesn't get our hair back, I give up, all studies point to this being the golden ticket.

[JDW]

where is this available in oral form at the moment?

[2020]

When will we know if this works?

every piece of information related to OC0459 is in this thread:

http://www.hairlosshelp.com/forums/messageview.cfm?catid=7&threadid=99747&STARTPAGE=1&FTVAR_FORUMVIEWTMP=Linear

GangsterBoy is in charge. His latest post:

Its been deleyed Probably for 2-3 weeks. Its seems much harder then the estimated to get it for human usage wich is 99%. So they are now purifying it intill its reaches the minimum of 99% pure. This product is not well documented on how to get it this pure, thats why it takes time.


We have to be a bit more patience .

[youngsufferer]

When will we know if this works?

[2020]

Any news? Aren't you guys scared of trying this thing since it's not tested?

it's been tested IN ITS ORAL FORM - 200 mg a day on hundreds of people and it was declared safe.

straight from their website:

OC000459 has demonstrated an excellent safety profile in over 800 subjects

[Aston]

Blocking PGD2 in scalp can only do good and the quantity that goes systemic will be too low to do anything. The only really worry is whether the product is pure enough, which it presumably will be.

[Davey Jones]

Any news? Aren't you guys scared of trying this thing since it's not tested?

Fortune favors the fearless.

[Gjm127]

Any news? Aren't you guys scared of trying this thing since it's not tested?

[Pate]

Are there any obtainable compounds that act as PGE2? I'd love to see 2020 go through with it.

2020 knows more about this stuff than I do, but isn't bimatoprost actually a PGE analog? I believe it is...

Im very curious about histogen and prostaglandins. Does HSC involve prostaglandins? Theyre getting good growth rates, surely that means they are restoring the balance in good and bad PG's?

HSC doesn't involve PGs specifically, it involves growth factors. Before the PG link was publicised, you could say the same thing about DHT - if HSC can regrow hair surely that means it is correcting the DHT imbalance in the scalp, right?

But no, it doesn't actually mean that. It could just be that the growth factors have a far more fundamental effect that the DHT and its evil PG henchmen can't fight against.

The other possibility is that the growth factors do somehow trigger a reaction that restores PG balance back to its pre-balding state.

Nobody knows yet. All we know is that HSC appears to grow hair even though it doesn't directly use PGs.

[ccmethinning]

come on dude.... those people on IH take everything to the extreme too and NO ONE has regrew any hair. When can we put this "MPB due to lifestyle" theory to rest???

I personally know people who are pretty much on life support due to the number of drugs they're taking and yet they have a full head of hair. Explain that

Nobody is saying a bad diet causes MPB. You are either predispositioned to it or you're not. But perhaps certain lifestyles and diets either accelerate or decelerate the progression MPB.

[2020]

Just to stir the moldy pudding over here: http://www.ncbi.nlm.nih.gov/pubmed/11589743

(@Gutted: it seems the production of TNFa is typically increased during metabolic imbalances connected to certain dietary disorders and is a major inflammation kickstarter.)

come on dude.... those people on IH take everything to the extreme too and NO ONE has regrew any hair. When can we put this "MPB due to lifestyle" theory to rest???

I personally know people who are pretty much on life support due to the number of drugs they're taking and yet they have a full head of hair. Explain that