Replicel

[Maradona]

Actually he's pretty much right about the first part, and Histogen wouldn't disagree.

He is right that they haven't proven they can grow new follicles in vivo because they haven't tested it on bald scalp - they have only tested it in areas of thinning where all the follicles are still producing hair, but vellus hair. The increase in hair count is most likely just because the terminal hairs are in anagen for so much longer, so more hairs are in anagen at any one time.

I would actually be kind of worried if HSC was producing new follicles in this situation because it would mean the follicle density in the skin actually increased above what it was at birth! Much better that in this situation, HSC just migrates to the existing follicles and reverses the miniaturisation.

When they get around to testing it on bald scalp, then we'll see if they are making new follicles - or possibly if they perfect HSC to the stage where they can prove HSC-treated areas have a higher FU density than hair in the permanent zone.

I think he's actually also technically correct that the growth factors are present in the scalp all the time too - it's just that HSC recreates the embryonic environment where they are present in much greater concentrations. But obviously to say it "isn't anything new" is a distortion.

It is one of the best interests of any company NOT TO TEST on a BALD SCALP.

I was very happy when I asked replicel where they were injecting their stuff and they told me on NW3's temples but they LIED to me. It went downhill from then.

Just forget about companies injecting on bald scalps especially those that do not involve HM. At this point, I don't consider Replicel HM. It will be without doubt hair rejuvenation.

[Pate]

Right. And can you prove ANY of those assumptions? No. So I would rather believe the words of the people who are actually DOING the study than some naysaying negative nobody on a forum.

Actually he's pretty much right about the first part, and Histogen wouldn't disagree.

He is right that they haven't proven they can grow new follicles in vivo because they haven't tested it on bald scalp - they have only tested it in areas of thinning where all the follicles are still producing hair, but vellus hair. The increase in hair count is most likely just because the terminal hairs are in anagen for so much longer, so more hairs are in anagen at any one time.

I would actually be kind of worried if HSC was producing new follicles in this situation because it would mean the follicle density in the skin actually increased above what it was at birth! Much better that in this situation, HSC just migrates to the existing follicles and reverses the miniaturisation.

When they get around to testing it on bald scalp, then we'll see if they are making new follicles - or possibly if they perfect HSC to the stage where they can prove HSC-treated areas have a higher FU density than hair in the permanent zone.

I think he's actually also technically correct that the growth factors are present in the scalp all the time too - it's just that HSC recreates the embryonic environment where they are present in much greater concentrations. But obviously to say it "isn't anything new" is a distortion.

[Kiwi]

Right well its saturday.. which can only mean one thing... FETUS TIME!!!

See you all on monday with a NW1!!!

Making fetus time?

Boom!! Now thats what all us balding bros should be doing on the weekend :P

[UK_]

Right well its saturday.. which can only mean one thing... FETUS TIME!!!

See you all on monday with a NW1!!!

[Kiwi]

Right. And can you prove ANY of those assumptions? No. So I would rather believe the words of the people who are actually DOING the study than some naysaying negative nobody on a forum.

Your comment about "growth factors being secreted all the time on the scalp which means Histogen blah blah blah" is lunacy - Histogen have recreated a bioengineered process that mimics the cellular environment during embryogenesis, that is, the time before you even resemble a ****ing human being. This environment is not "always on your scalp" - it happens ONCE and only once, unless you revert to being a fetus every weekend like some kind of alien.

Histogen naysayers please visit the following site and stay there:

http://www.************/

hahahahahhahhaha!!!

nicely put... but whatever you say i like both you guys

[UK_]

??? hair count is not the same as the number of hair follicles. You certainly have much much more actual hair than follicles. HSC may stimulate existing follicles to produce better hair. Also, the growth factors they're using are being secreted all the time on your scalp so this isn't anything new.

Right. And can you prove ANY of those assumptions? No. So I would rather believe the words of the people who are actually DOING the study than some naysaying negative nobody on a forum.

Your comment about "growth factors being secreted all the time on the scalp which means Histogen blah blah blah" is lunacy - Histogen have recreated a bioengineered process that mimics the cellular environment during embryogenesis, that is, the time before you even resemble a ****ing human being. This environment is not "always on your scalp" - it happens ONCE and only once, unless you revert to being a fetus every weekend like some kind of alien.

Histogen naysayers please visit the following site and stay there:

http://www.************/

[2020]

So how do you explain the difference in hair count from baseline to 12 weeks in BOTH studies?

??? hair count is not the same as the number of hair follicles. You certainly have much much more actual hair than follicles. HSC may stimulate existing follicles to produce better hair. Also, the growth factors they're using are being secreted all the time on your scalp so this isn't anything new.

[UK_]

so far Histogen was only able to grow BRAND NEW FOLLICLES in VITRO... from the past two studies they still weren't able to confirm if HSC did in fact grow any new follicles

So how do you explain the difference in hair count from baseline to 12 weeks in BOTH studies?

[Kiwi]

I don't like the sound of that at all. Only Bosley doctors will be able to work with Aderan's regeneration technique?
Has anyone ever had a good transplant from Bosley?!

Tracy doesn't know that as a fact - nobody does - and besides aderans want to make as much money as possible so I doubt it'll be exclusive.

@Tracy - heck even if they do have to FUE those babies into my head you can sign me the hell up!!! I'll take 3000 grafts thank you very much

[25 going on 65]

That is exactly what I expect will eventually happen, only Aderans will not be involved. Aderans will be doing their own exclusive thing through Bosely and Hair Club.

I don't like the sound of that at all. Only Bosley doctors will be able to work with Aderan's regeneration technique?
Has anyone ever had a good transplant from Bosley?!

[2020]

so far Histogen was only able to grow BRAND NEW FOLLICLES in VITRO... from the past two studies they still weren't able to confirm if HSC did in fact grow any new follicles

[paulsreef]

I was thinking the very same thing earlier today in training class as I stared at the two close buzzed (maybe week out from shaves?) NW5 and NW6s in front of me.

Both looked fine, but the one guy clearly could put on some upper body size. I think I'm small but damn he barely had an upper arm.

I believe arm transplants have been done.

[NotBelievingIt]

Imagine if you could grow new follicles with Histogen, Aderans or whatever....then immunize them with Replicel!

That is exactly what I expect will eventually happen, only Aderans will not be involved. Aderans will be doing their own exclusive thing through Bosely and Hair Club.

I was thinking the very same thing earlier today in training class as I stared at the two close buzzed (maybe week out from shaves?) NW5 and NW6s in front of me.

Both looked fine, but the one guy clearly could put on some upper body size. I think I'm small but damn he barely had an upper arm.

[Tracy C]

Imagine if you could grow new follicles with Histogen, Aderans or whatever....then immunize them with Replicel!

That is exactly what I expect will eventually happen, only Aderans will not be involved. Aderans will be doing their own exclusive thing through Bosely and Hair Club.

Currenty, the only way Aderans can get the direction of growth right is to grow follicles in donated skin, then harvest the new follicles from the donated skin in an FUE style procedure so they can then be replanted in your scalp as is done during a traditional hair transplant. Aderans might be the first to offer a solution but it won't be the best - and it won't be the most cost effective. Too many steps. The more steps you have in a process the more opportunity you will have to encounter problems.

[25 going on 65]

Fingers crossed they'll have good news at the end of the year.

Fingers crossed histogen has amazing results end of the year.

Imagine if you could grow new follicles with Histogen, Aderans or whatever....then immunize them with Replicel!

Obviously I'm just talking out of my ass but it's nice to live in a time where there is actual hope that things will get better for hair loss sufferers (ie most adults in the world)