CB-03-01 - new antiandrogenic

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  • FearTheLoss
    Senior Member
    • Dec 2012
    • 1581

    CB for acne was scheduled for 2015..for alopecia it was originally 2016 or 2017 I believe..and no it, in preclinical trials, looked to be a stronger version of propecia without side effects.

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    • yan
      Senior Member
      • May 2013
      • 156

      Cosmo update

      Update from Cosmo:



      CB-03-01 Phase II data for acne look very promising.

      - Phase II dose ranging trial completed
      - Best dose identified
      - 1.0% BID (twice a day) treatment group had the best results
      - No adverse events
      - Phase III scheduled to start Q4 2014.


      I think the acne version will be out in 2016. Alopecia 2017 - 2018.

      Comment

      • burtandernie
        Senior Member
        • Nov 2012
        • 1563

        Every time I see someone mention CB its a different number of years until it comes out. I think the last one on here I read he said 6 years which puts it at 2020 or 2021? I hope im not dead by then

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        • JZA70
          Member
          • May 2014
          • 71

          Originally posted by burtandernie
          Every time I see someone mention CB its a different number of years until it comes out.
          That's speculation at it's finest.

          Comment

          • cthulhu2
            Member
            • Jun 2014
            • 71

            Originally posted by lilpauly
            Cosmo announces successful conclusion of acne Phase II trial and agreement with Valeant to continue developing CB-03-01 in house

            Lainate, Italy – July 8, 2014 – Cosmo Pharmaceuticals S.p.A. (SIX: COPN) today informed that it had successfully concluded the phase II acne trials of CB-03-01 and that, prior to the upcoming end of phase II meeting with the FDA, both Cosmo and Valeant Pharmaceuticals International, Inc., the licensee (NYSE / TSX: VRX), had agreed that it was preferable for both parties for Cosmo to continue developing the drug. Consequently both Cosmo and Valeant agreed to unwind the present agreement and replace it with an agreement granting Valeant a right of first refusal should Cosmo decide to license out the drug after completing its development.Alessandro Della Chŕ, CEO, commented: “I am very pleased by the results of this phase II, and even more pleased that Cosmo can continue developing the products in-house, leveraging on all the accumulated know how. Their potential is very significant, so the retention of the rights now allow us to create a stronger franchise in the derma field. Together with CB-03-01 we now have 5 products in clinical development. Given our strong financial position and in-house expertise, we are well equipped to exploit the potential of this rich pipeline for the benefit of patients and shareholders”."

            http://www.cosmopharma.com/news/press/2 ... 07-08.aspx
            I don't understand why people are so negative, this is great news! Think about all of the other topical anti androgens that were in the pipeline (neosh-101, asc-j9, ru) and failed to make it into phase III. I don't think we have to worry about the fact that the alopecia trials are lagging behind the acne trials since doctors would likely prescribe it off label to treat AGA (think dutasteride).

            Comment

            • lothar99
              Member
              • Jul 2011
              • 36

              There is a new PDF up today from Cosmo's "Investors and Analysts Meeting" in Germany. They do discuss the Phase 2 acne results (but no vehicle) and they call the results "very promising", there were no "adverse events", and Phase 3 begins this year.

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              • ShookOnes
                Senior Member
                • Jun 2014
                • 209

                Originally posted by cthulhu2
                I don't understand why people are so negative, this is great news! Think about all of the other topical anti androgens that were in the pipeline (neosh-101, asc-j9, ru) and failed to make it into phase III. I don't think we have to worry about the fact that the alopecia trials are lagging behind the acne trials since doctors would likely prescribe it off label to treat AGA (think dutasteride).
                this is exactly the point of the trials to the blind uneducated idiots that can't see through this. Comso is an enormous financially powerful company. They would know that something for DHT would be much more difficult to get through FDA as it is hormones you are trying to affect, which would require quite some more time than good ol' acne cream. Acne cream which has a side effect of stopping baldness if you apply on scalp. dear lord i should get my transplant soon.

                Comment

                • ShookOnes
                  Senior Member
                  • Jun 2014
                  • 209

                  Originally posted by BoSox
                  Is CB still on schedule to be released 2015 in the US? Also, is this only a stronger form of Rogaine? I'm a diffuse thinner, and worried nothing will work on me a year from now.
                  I'm a diffuser also. Went form NW 0 -> 3 with thin scalp in 2 years. GET ON FIN. Diffusers are alike, it will regrow everything except temples in a year. Stop the fin after you regrow everything because CB will be available then.
                  CB is scheduled for acne in 2015, if we get it off label then the game will be different in a year for us, brother. If not, 2016 will be the year for AA at the latest.

                  And NO, it is not just a stronger form of rogaine. It is basically rogaine+fin on steroids. I believe you only need to apply it once a week on the scalp also.

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                  • LMS
                    Senior Member
                    • Dec 2012
                    • 226

                    Originally posted by ShookOnes

                    And NO, it is not just a stronger form of rogaine. It is basically rogaine+fin on steroids. I believe you only need to apply it once a week on the scalp also.
                    CB is just an anti androgen much like RU, sans sides. Its also a mild anti inflammatory due to being a potent steroidal anti androgen. Far from anything like rogaine...

                    Comment

                    • ShookOnes
                      Senior Member
                      • Jun 2014
                      • 209

                      whoops i mean 2017/2018? how come you can't edit posts after a few hours ;s

                      Comment

                      • sdsurfin
                        Senior Member
                        • Sep 2013
                        • 702

                        You don't know any of this, nor do I think it's even accurate. CB has only just begun preclinical trials for AA(clinical trials take 8 years). I spoke to them a while back and they said that if the acne version proves safe, then it might take a couple years off the testing time for AA. still looking at 5 years or so. Also, they were pretty vehement that the acne version will do nothing for AA. They said the concentration is different and the vehicle is totally different. Which means that we will still be at the same place with it as we are now, until they come out with the aa version (if it works and they ever do). Lotta ifs here, and no way it comes to market that soon. They just filed the IND, and you can't go around saying it's like "rgaine and fin on steroids" when all we have to back that up is one little trial that used iontophoresis, which we can't use anyway. Anyhow a lot of the time these initial trials don't mean squat. RU and other compounds had great initial trials and then failed. Not trying to be negative or say that it won't be a great drug, it might be. But let's stop getting people all hyped up, especially with these bogus timelines.

                        Comment

                        • sdsurfin
                          Senior Member
                          • Sep 2013
                          • 702

                          Originally posted by ShookOnes
                          this is exactly the point of the trials to the blind uneducated idiots that can't see through this. Comso is an enormous financially powerful company. They would know that something for DHT would be much more difficult to get through FDA as it is hormones you are trying to affect, which would require quite some more time than good ol' acne cream. Acne cream which has a side effect of stopping baldness if you apply on scalp. dear lord i should get my transplant soon.

                          this statement makes no sense. They are both used to block DHT. they are testing acne first because it's a bigger and more reliable market. period. It's also easier to treat acne than alopecia, and can be used for women and men. Also you will not be able to use the acne version on your head. Cosmo confirmed this to me a while back, so stop getting people all hyped on the idea. It's a different concentration and vehicle, and you can't just remove the chemical from the cream or something. I doubt CB will even work for alopecia, vehicles are not that complicated and people have been getting no results from this on the black market. Just because it worked with iontophoresis doesn't mean that it will ever work as a topical.

                          Comment

                          • sascha
                            Senior Member
                            • Feb 2014
                            • 147

                            Actually the website of cosmo states that IND for CB 03 01 for acne was in Q1 2012, began phase 2 in H2 2012 And as you all may know, finished phase 2 a couple of days ago.
                            They should have filled the IND for CB 03 01 for alopecia in H1 2014.
                            Q1 2012 -> July 2014 = around 28 months for the acne version.
                            To all Inspector Gadgets out there, have fun

                            Comment

                            • ShookOnes
                              Senior Member
                              • Jun 2014
                              • 209

                              Originally posted by sdsurfin
                              this statement makes no sense. They are both used to block DHT. they are testing acne first because it's a bigger and more reliable market. period. It's also easier to treat acne than alopecia, and can be used for women and men. Also you will not be able to use the acne version on your head. Cosmo confirmed this to me a while back, so stop getting people all hyped on the idea. It's a different concentration and vehicle, and you can't just remove the chemical from the cream or something. I doubt CB will even work for alopecia, vehicles are not that complicated and people have been getting no results from this on the black market. Just because it worked with iontophoresis doesn't mean that it will ever work as a topical.

                              2010, http://www.cosmopharmaceuticals.com/...010-10-06.aspx

                              Mauro Ajani, Chief Executive Officer of Cosmo Pharmaceuticals, said: “We are extremely pleased with this result. This is the first step towards establishing CB-03-01 as an effective, topically applied anti-androgen and could therefore mark a major breakthrough for all men and women affected by androgenetic alopecia. Currently the only FDA approved anti-androgen for this condition is Propecia..."

                              True but you're just a guy on the internet criticizing a financially driven billion-dollar company that's trying to knock down propecia and take over the entire market. And they're still progressing with this, 4 years later. i belib

                              Comment

                              • Phatalis
                                Senior Member
                                • Dec 2009
                                • 263

                                This might be a rediculous question. But if CB already works miraculously with iontopherorsisisis or whatever... why the **** cant we just like... do that? get treatments with that?

                                Like.. idk. Can't they make a machine for home use?? Idk.. tell me why im dumb

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