CB-03-01 - new antiandrogenic

[yan]

Note that CB-03-01 is now into Phase II for acne and they report no serious side effects, and it's also applied to the skin (however I don't know how often), so maybe they avoided skin atrophy side effect somehow.

Daily for acne... And I guess you have to use it daily too for alopecia...

[TravisB]

Wikipedia article on steroid skin atrophy

http://en.wikipedia.org/wiki/Steroid_atrophy

This article says that corticosteroids cause skin atrophy. Meanwhile CB-03-01 is steroidal ester.

Is there a difference between corticosteroid and steroidal ester?

Maybe CB-03-01 don't have the potential to cause skin atrophy afterall?

Don't you think if there was skin atrophy they would observe this in the trials by now? Meanwhile they state there were no side effects (they are now into phase II for acne, and they did pilot study for MPB)

[yan]

Wikipedia article on steroid skin atrophy

http://en.wikipedia.org/wiki/Steroid_atrophy

That article scares me so hard...

"The potential for the condition exists whenever topical corticosteroids are used, even with low potency preparations."

If I read this article, it seems like it is 100% sure you will get that side effect...

[hellouser]

That article scares me so hard...

"The potential for the condition exists whenever topical corticosteroids are used, even with low potency preparations."

If I read this article, it seems like it is 100% sure you will get that side effect...

Best to talk to some doctors and ask Cosmo as well in regards to this.

[TravisB]

That article scares me so hard...

"The potential for the condition exists whenever topical corticosteroids are used, even with low potency preparations."

If I read this article, it seems like it is 100% sure you will get that side effect...

Then how come they didn't report it in the trials? The trials are going for some time now and if they apply it every day as you said the skin atrophy would be visible very fast.

Meanwhile they stated today that there are no serious side effects so far, and they are already into phase II.

I think they know what they are doing

[yan]

Interesting fact:

CB-03-01 = Cortodoxone, also known as cortexolone or 11-deoxycortisol

"Cortodoxone functions as a glucocorticoid, though is less potent than cortisol."

https://en.wikipedia.org/wiki/Cortodoxone

Topical steroids are classified according to their strenght.

http://en.wikipedia.org/wiki/Topical_steroid

Class IV (up to 600 times as potent as hydrocortisone (Cortisol))

...
Class II (2-25 times as potent as hydrocortisone (Cortisol))

Lowest class is Class I (mild - as potent as hydrocortisone (Cortisol))


So it looks like CB-03-01 is even milder than the current lowest defined class. Its less potent than cortisol itself.

Maybe that would explain why they reported no side effects so far. We have to consider that they used CB on the face. The face is far more sensitive to corticosteroids than the scalp.

I guess they are not stupid. They wouldn`t even consider CB as a treatment for MPB if it had such serious side effects like skin atrophy.

[TravisB]

I guess they are not stupid. They wouldn`t even consider CB as a treatment for MPB if it had such serious side effects like skin atrophy.

Exactly

IMO there's a very good chance CB-03-01 will be our new, better standard after Finasteride.

However I don't think the alopecia version will be on the market until 2017-2019. But perhaps acne version will also be effective for MPB, we'll see.

There's a chance that acne version will be on the market in 2016.

[hellouser]

Exactly

IMO there's a very good chance CB-03-01 will be our new, better standard after Finasteride.

However I don't think the alopecia version will be on the market until 2017-2019. But perhaps acne version will also be effective for MPB, we'll see.

There's a chance that acne version will be on the market in 2016.

Once the acne version hits the market or comes close, the black market copy of it should be EASILY reproduced and used on our own. We're nearly there already anyway.

[TravisB]

Once the acne version hits the market or comes close, the black market copy of it should be EASILY reproduced and used on our own. We're nearly there already anyway.

There already is CB-03-01 on black market, and some people used it with no results. So the explanation is:

1. The CB-03-01 on black market is fake
2. Vehicle is the problem (of course when CB-03-01 will hit the shelves it will have the right vehicle)

[hellouser]

There already is CB-03-01 on black market, and some people used it with no results. So the explanation is:

1. The CB-03-01 on black market is fake
2. Vehicle is the problem (of course when CB-03-01 will hit the shelves it will have the right vehicle)

Even if it hits shelves for acne, the vehicle will be anhydrous for hair loss, which is 1-2 years after the acne product.

Pretty fvcking dumb of cosmo to release a product for acne when theres so much stuff for that issue and so many more men suffering from hair loss and so much more SHIT on the market that doesnt work.

[KeepHoping]

Are you gonna trail the iron dragon stuff?

[hellouser]

Are you gonna trail the iron dragon stuff?

I'm considering it. The price is ridiculously low. However I wonder how much $45 gets you.

Only issue with Iron Dragon is purity. If anyone knows if Iron Dragon is reliable, please let me know

[KeepHoping]

I'm considering it. The price is ridiculously low. However I wonder how much $45 gets you.

Only issue with Iron Dragon is purity. If anyone knows if Iron Dragon is reliable, please let me know

I have no idea man, I know people have been trying stuff off their website but I'm not sure to what extent it really works.

[KeepHoping]

Also even if it only gets you a small amount, do you really need a lot of the product? In the trial it was used once a week right?

[yan]

My faith is restored in CB after this little research...