Anyone planning on taking the *new* Hasson and Wong liposomal topical fin?

[79BirdofPrey]

Question: I took Fin tablets and did not experience any negative sides, but didn't experience any hair regrowth either. I was on it for about 1 year.

Does topical Fin improve the efficacy of the product? If I didn't experience regrowth with oral fin, would my chances improve with topical?

[Bobbylobbyhobbythrobby]

I'm not sure of the regularity in which the topical fin needs to be applied. However perhaps applying this at night and minox in the morning may suffice to limit/reduce any systemic absorption? My initial plan was to drop Minox entirely, however if it transpires that the fin topical doesn't even need to be applied everyday then I may continue with the Minox.

I'm not sure on the exact science, I know that a few others don't think that this topical work any differently (in terms of sides) to oral fin, however I don't know if H&W binding it with the liposome will stop it going systemic or not.

I guess there's only one way to find out.

[willy]

For those people intending to use this in an effort to avoid sides... will you drop other topicals? Or switch to alternating application of topicals?

My concern is that assuming the H&W vehicle reduces systemic absorption, applying minox or any other topical will cause the finasteride to be absorbed anyway through PPG / alcohol etc. Thoughts?

[Bobbylobbyhobbythrobby]

I took Fin 3+ years ago. Terrible sides within a week so I stopped. Have not taken fin or minox ( or anything else) since. Got a blood test Monday in anticipation of this new topical fin being available in the US. Once H&W release it in the US I'll take it as well as get new blood tests. ( prob after 45-90 days assuming no immediate felt sides). Happy to post both sets of blood tests at that point.

Seperatley, I'm also gonna write a note to see the duration of the 100+/- person study that H&W did. 1/18 systemic levels vs oral may be great for initial dosing. But as Fin can reduce DHT levels for multiple days (4 according to one study) the gradual build up of 1/18s can ultimately arrive at oral systemic levels (also the reason for my 45-90 day period above)

http://www.ncbi.nlm.nih.gov/pubmed/8846625

Crossing my fingers

Yeah would be interesting to see your blood DHT results. When does it become available in the US? I know that over here (EU) we have to buy it through the Italian pharmaceutical company, and their standard protocol is to mix it with 2.5% Fin concentration, if you want less e.g 0.5% you have to specify that when ordering. I am not sure if it is the same if you are buying directly from Hasson and Wong though.

[FuzzyWuzzy]

I took Fin 3+ years ago. Terrible sides within a week so I stopped. Have not taken fin or minox ( or anything else) since. Got a blood test Monday in anticipation of this new topical fin being available in the US. Once H&W release it in the US I'll take it as well as get new blood tests. ( prob after 45-90 days assuming no immediate felt sides). Happy to post both sets of blood tests at that point.

Seperatley, I'm also gonna write a note to see the duration of the 100+/- person study that H&W did. 1/18 systemic levels vs oral may be great for initial dosing. But as Fin can reduce DHT levels for multiple days (4 according to one study) the gradual build up of 1/18s can ultimately arrive at oral systemic levels (also the reason for my 45-90 day period above)

http://www.ncbi.nlm.nih.gov/pubmed/8846625

Crossing my fingers

[Bobbylobbyhobbythrobby]

I went to my GP here in the UK, and they won't fill the form out. And when I go to a private Dermatologist, they will only prescribe their own more expensive brand of oral fin. So I don't really know how we're supposed to get this topical. I'm also a little bit surprised that no one has done a DHT test before taking the new topical and after a few weeks to see if it does go systemic or not. I would do it but it will cost a lot to test. Maybe I should do a go fund me start up that will pay for the tests so we can all know for sure before taking it.

[mowingdown]

liposome.

So as far as I know you're the only person on this forum using it.. How long have you been on it? Notice any difference? Ton of questions!

[Vishnu018]

does anyone know a doctor in france who would accept to make such prescription? Until now they have all refused to write me one.

[FeelsBad]

I emailed the italian pharmacy and it seems they will make it in lower concentrations. They sent me a prescription to be filled out by my doctor for a .5% solution when I requested it.

[burtandernie]

What we need is a DHT receptor blocker that works on the hair follicle. I can see a liposomal topical working that way.

Yeah we do. CB has been in development for years and its still like 4 or 5 years until we ever actually get it. It just takes forever to actually release anything. Anything thing else just is underground and never gets the scale or numbers to become that cost effective. Not to mention safety and all that never really happens. Look at RU no one has clue if its safe or not many years after forum people have been using it anyway
Maybe someone can test the potency of RU and we get a legit company making it formulated as a real topical product. DHT receptor blockers exist just none ever get finished. They come and go no company ever actually finishing one of them

[barfacan]

What we need is a DHT receptor blocker that works on the hair follicle. I can see a liposomal topical working that way.

[stratowich]

What we need is something like this:

[timmay9000]

Dosing question here :

According to their prescription, it's a 2.5% solution (https://hassonandwong.com/wp-content...eride-form.jpg)

1 ML daily dose = 25mg Finasteride. They claim only 1/18th goes systemic. 25/18 = ~1.39 mg finasteride systemically absorbed.(Is that what they mean by serum levels are 1/18th? that's just a little confusing to me) That's more than the standard Fin oral dose, is it not?

Am i missing something?

As far as I can tell, your math is spot on. And equally as befuddled.

[barfacan]

Valid point, I was a little stumped by this at first since I forgot finasteride was an AR type 2 inhibitor and not a dht inhibitor. However, balding scalps have higher expression of 5 alpha reductase type II and when people take oral finasteride, their scalp dht levels only go down by roughly 40-50% from one of the studies I have seen on propecia, meaning their isn't a complete equilibrium between the scalp and blood levels of dht. Maybe dht produced in the prostate doesn't have the same deleterious effects on the hair follicle idk.

Yeah but we dont know the relative amounts of 5ar2 activity in scalp vs in other areas of the body (or do we?), if there is a very high concentration of 5ar2 in scalp then this product has the possibility of working well. But if the concentration is highest elsewhere in the body, then a non systemic topical is next to useless is it not? But i think we already had this discussion in another thread

[barfacan]

Dosing question here :

According to their prescription, it's a 2.5% solution (https://hassonandwong.com/wp-content...eride-form.jpg)

1 ML daily dose = 25mg Finasteride. They claim only 1/18th goes systemic. 25/18 = ~1.39 mg finasteride systemically absorbed.(Is that what they mean by serum levels are 1/18th? that's just a little confusing to me) That's more than the standard Fin oral dose, is it not?

Am i missing something?