Will an official cure ever be found? Honestly

[justbreezy]

I hope Replicell can do something, simply because they projected a 2018 release. I might last till then

However, i think there is a cure already. We just can't access it because of the issues around genenome editing. CRISPR CAS9 can eliminate MBP genes from future generations, it seems like you could essentially reverse gene damage too in current generations. I'm not an expert, but surely they can use this to reverse or even to discover more easily the causes behind MPB.

https://www.youtube.com/watch?v=TdBAHexVYzc

[jamesst11]

I hope Replicell can do something, simply because they projected a 2018 release. I might last till then

However, i think there is a cure already. We just can't access it because of the issues around genenome editing. CRISPR CAS9 can eliminate MBP genes from future generations, it seems like you could essentially reverse gene damage too in current generations. I'm not an expert, but surely they can use this to reverse or even to discover more easily the causes behind MPB.

https://www.youtube.com/watch?v=TdBAHexVYzc

There are way too many genes involved in everything that is MPB to consider editing DNA sequences to cure it. I don't think this will ever be a possibility for AGA.

[Link Mahboi]

It is still worth a "shot", James.. You clearly underestimate the potential of this technology, and I'm talking about even bigger things than AGA.

[BaldingEagle]

It is still worth a "shot", James.. You clearly underestimate the potential of this technology, and I'm talking about even bigger things than AGA.

James like myself has a masters in molecular biology. I think it's you who's overestimating this technology. Full genetic comprehension is decades away.

[jamesst11]

It is still worth a "shot", James.. You clearly underestimate the potential of this technology, and I'm talking about even bigger things than AGA.

I definitely agree it is worth a shot, and I might be completely wrong. Hell, I haven't really studied molecular bio for 7 years...I am just falling short in understanding exactly how it would work that's probably because I know very little about follicle physiology. Would they isolate the DP cells, sequence the DNA, alter it and then clone them with altered DNA? As in a DP cell with no androgen receptors at all? I don't know.. don't know much about this.

[BaldingEagle]

How about Replicel shows efficacy in vivo before we get all excited.

[justbreezy]

http://www.cnet.com/news/genetically-engineered-micropigs-to-be-sold-as-pets-yes-micropigs/

http://www.hairlosscure2020.com/brief-items-of-interest-january-2016/

Well according to various videos explaining, the CRISPR technology makes it more affordable and anybody with a particularly degree to manipulate and change the DNA. This is happening in the animal and plant world already, but the CRISPR technology should make this easier for anybody with a degree in biology to make these changes apparently. Could still need time to test, find the issues in the DNA sequences. I think they already found the defective chromosomes common in people with accelerated MPB? I'm just saying, maybe they can use this to even just bring a suitable topical treatment to the table quicker.

[paleocapa89]

Isn't ultimately this what FGF11 is trying in an other thread "I think I've hacked it"

He is trying to silence the androgen receptor by gene editing if I understood him correctly.

[Link Mahboi]

I definitely agree it is worth a shot, and I might be completely wrong. Hell, I haven't really studied molecular bio for 7 years...I am just falling short in understanding exactly how it would work that's probably because I know very little about follicle physiology. Would they isolate the DP cells, sequence the DNA, alter it and then clone them with altered DNA? As in a DP cell with no androgen receptors at all? I don't know.. don't know much about this.

I don't have any degree in any scientific matter, so, forgive me if it's a stupid question.. If you are able to modify the "genetic source" of a living creature, would it's body eventually adapt to that mutation? (Like, if you modify the DNA sequence related to it's height, would it, in time, grow bigger/ taller? ) Or only it's descendants would be able to benefit from such change?
From what I've seen from this technology, it seems they were able to alter the phenotype of a living mice, changing it's fur colour. I've readed somewhere else aswell that a team of scientists, using that technology, were able to "cure" two teenagers with a degenerative disease. Perhaps I'm overestimating CRISPR indeed, but.. Maybe if we were able to indentify the genes responsible for AGA and remove them, wouldn't our bodies adapt to that modification and resume our normal hair cycle / growth? I don't know, I think that, perhaps, I'm just emotionaly attached to that possibilty, sorry if I sounded a bit hostile with you implying otherwise, I just can't stand this disease anymore, and I'm also, like many young men here, desperate for a quick fix for this condition. The sooner, the better, cuz.. I won't be on my tweenties forever, and I fear that, even if the cure comes, It won't matter anymore once I've been stolen from my youth.

[justbreezy]

I don't have any degree in any scientific matter, so, forgive me if it's a stupid question.. If you are able to modify the "genetic source" of a living creature, would it's body eventually adapt to that mutation? (Like, if you modify the DNA sequence related to it's height, would it, in time, grow bigger/ taller? ) Or only it's descendants would be able to benefit from such change?
From what I've seen from this technology, it seems they were able to alter the phenotype of a living mice, changing it's fur colour. I've readed somewhere else aswell that a team of scientists, using that technology, were able to "cure" two teenagers with a degenerative disease. Perhaps I'm overestimating CRISPR indeed, but.. Maybe if we were able to indentify the genes responsible for AGA and remove them, wouldn't our bodies adapt to that modification and resume our normal hair cycle / growth? I don't know, I think that, perhaps, I'm just emotionaly attached to that possibilty, sorry if I sounded a bit hostile with you implying otherwise, I just can't stand this disease anymore, and I'm also, like many young men here, desperate for a quick fix for this condition. The sooner, the better, cuz.. I won't be on my tweenties forever, and I fear that, even if the cure comes, It won't matter anymore once I've been stolen from my youth.

Well we know for a fact they're talking about human engineering from birth, this is great for the next generation if they decided that we can remove these defects such as an early onset of MPB. It can be used in drug development, research and perhaps entered into the human body as stem cells in a treament similar to replicel. Replenish your defected Dermal Papilla/Sheath cup cells with MPB disease free cells? Allowing you to grow healthy unminaturized follicles?

If i could go into my 40s with hair on my head then i would be happy. After that, i'd accept my age and let myself be bald.

In China it seems they're creating breeds of micro pigs for consumers to buy. Is it hard to conceive they could make a tweak to our DNA and reintroduce them as stem cells? Anyway, they're hoping to cure much more problematic and life threatening diseases, if they get round to it then i hope they can find a solution for MPB.

[kuba197]

What about Follica? Any news?

[hairloss2thickhair]

One of the things hair needs is collagen. One form of collagen is called biosil that can be bought at the drug store. It has no side effects and it is working for me. I wasn't completely bald but my shiny scalp was showing through at my crown in a big way. My hair has stopped falling out and is now growing back. Has anyone else tried this?

[garethbale]

One of the things hair needs is collagen. One form of collagen is called biosil that can be bought at the drug store. It has no side effects and it is working for me. I wasn't completely bald but my shiny scalp was showing through at my crown in a big way. My hair has stopped falling out and is now growing back. Has anyone else tried this?

Can we see pictures of your results please?

[k9gatton]

The one treatment I am sorry wasn't further investigated for hairloss (at least in the US) is Bimaprost.

It's very possible if scientists estimated the correct dosages, when it first came out, we would have it at this time. We will never know, unfortunately.

[PatientlyWaiting]

It seems to me that the closest thing to a cure is the advancement of FUE, which is acually not a cure. It's getting cheaper and if you go to the right doctor and have the right amount of donor hair, you can have an FUE that looks 100% natural and undetectable. But again, it's not a cure because all the stars have to align for it to be 100% successful (undetectable and satisfying).