Will an official cure ever be found? Honestly

[Swooping]

Hey Swooping, how are you doing ? I havent really followed Replicel myself. I know one thing though: the stock market never is wrong. REPCF currently trades at 21 cents and has a market cap of a lousy 13M usd, which is a joke, even for an OTC company. It's pretty much all one needs to know.

So not getting my hopes up on replicel ...

Hey Arashi,

Nice to see you back . I have been doing well. Got a hair transplant which turned out very well so that's excellent. Where have you been these times?

Thanks for the advice.

Honestly I'm not getting my hopes up at all for Replicel too. I just think hypothetically they might have a chance of immunizing (healthy) hair follicles, but if I had to bet my money I would bet that they are going to fail immediately. I see a glimmer of hope I guess that's all. There is a world of difference between a hypothesis and showing actual results obviously.

I guess we will just have to wait and "hope" for the best. Time will tell. We can't really do anything else I guess?

[allTheGoodNamesAreTaken]

What have Replicel actually shown in terms of results to deserve any interest anyway? As far as I'm aware they put out some underwhelming results a few years ago and nothing concrete since. I'm not putting any hope in them until they show some proper results and I don't know why stock traders would either at this moment.

[jamesst11]

Hey Arashi,

Nice to see you back . I have been doing well. Got a hair transplant which turned out very well so that's excellent. Where have you been these times?

Thanks for the advice.

Honestly I'm not getting my hopes up at all for Replicel too. I just think hypothetically they might have a chance of immunizing (healthy) hair follicles, but if I had to bet my money I would bet that they are going to fail immediately. I see a glimmer of hope I guess that's all. There is a world of difference between a hypothesis and showing actual results obviously.

I guess we will just have to wait and "hope" for the best. Time will tell. We can't really do anything else I guess?

Shit, I just bought 10,000 shares of Replicel stock and you tell me this NOW???

[wriggles]

Hey Arashi,

Nice to see you back . I have been doing well. Got a hair transplant which turned out very well so that's excellent. Where have you been these times?

Thanks for the advice.

Honestly I'm not getting my hopes up at all for Replicel too. I just think hypothetically they might have a chance of immunizing (healthy) hair follicles, but if I had to bet my money I would bet that they are going to fail immediately. I see a glimmer of hope I guess that's all. There is a world of difference between a hypothesis and showing actual results obviously.

I guess we will just have to wait and "hope" for the best. Time will tell. We can't really do anything else I guess?

Is there any reason you think they are going to fail?

[FloydButterworth]

Is there any reason you think they are going to fail?

Yes, their absolutely terrible results from phase I. Also, all this talk of them "immunizing" against baldness is absolutely ridiculous. There is not a single shred of evidence that their treatment can do that. Not in animal models, not invitro, and certainly not in humans. It's hype from the corporate board at replicel. The same guys who paid a stock pumper to scream from the roof tops that they have cured mpb right before they released phase I results. Watching them try to distance themselves from that was quite the spectacle. This treatment is a very long shot to even beat minoxidil. I'm rooting for them, but, honestly i think they have very little chance of sucess and that's simply a reflection of the beast that they're up against. MPB destroys companies almost as well as it destroys hairlines.

[dutchguyhanging]

Yes, their absolutely terrible results from phase I. Also, all this talk of them "immunizing" against baldness is absolutely ridiculous. There is not a single shred of evidence that their treatment can do that. Not in animal models, not invitro, and certainly not in humans. It's hype from the corporate board at replicel. The same guys who paid a stock pumper to scream from the roof tops that they have cured mpb right before they released phase I results. Watching them try to distance themselves from that was quite the spectacle. This treatment is a very long shot to even beat minoxidil. I'm rooting for them, but, honestly i think they have very little chance of sucess and that's simply a reflection of the beast that they're up against. MPB destroys companies almost as well as it destroys hairlines.

well i agree. If they were onto something big, they would have made such marketing campaigns....etc. people are done with speculations. no matter what.. i firmly believe they already guess or know phase2 outcomes even phase3 at least to what extent the treatment could work...

[jjo]

who cares about a cure right now? we need a better treatment that doesn't give sides and that would buy us all more time till a full cure does come out.

[Follisket]

Seriously, if the difference between a treatment and a cure lies exclusively in convenience then I don't freaking care if we ever get a cure. Hell, I'd be willing to do the chicken dance every night at 4 am dressed in a monkey suit if it worked and gave me a full head of hair. Just give me something that works 4fs.
I mean, they literally don't even have to figure out anything new necessarily. Just pretty copy the mechanism of existing AAs but block the side effects. And they've had decades to do that. For a tweak. Decades!

[jamesst11]

Seriously, if the difference between a treatment and a cure lies exclusively in convenience then I don't freaking care if we ever get a cure. Hell, I'd be willing to do the chicken dance every night at 4 am dressed in a monkey suit if it worked and gave me a full head of hair. Just give me something that works 4fs.
I mean, they literally don't even have to figure out anything new necessarily. Just pretty copy the mechanism of existing AAs but block the side effects. And they've had decades to do that. For a tweak. Decades!

Good point... they should just combine some finasteride with some viagra and call it finagra, or viasteride... man I am gonna be a millionaire

[doinmyheadin]

Good point... they should just combine some finasteride with some viagra and call it finagra, or viasteride... man I am gonna be a millionaire

Lol James you might be onto something. I think Floyd Butterworth summed up Replicel if you were on the forums before and after there phase one trials. Just because Shesiedo has invested in them doesnt mean squat. Sheseido sells Adenogen which has some great MPB figures during ther 'trails' but many people have used it and said it is a waste of time.

[dutchguyhanging]

Lol James you might be onto something. I think Floyd Butterworth summed up Replicel if you were on the forums before and after there phase one trials. Just because Shesiedo has invested in them doesnt mean squat. Sheseido sells Adenogen which has some great MPB figures during ther 'trails' but many people have used it and said it is a waste of time.

this is actually why i proposed to shut down the whole cutting edge sections... there is alot of dust noise around and at some point no one even knows which info is correct or valuable...

[kuba197]

https://www.*************/news/what-...-biotech-space

[rlbrown68]

More like 20 years we've been teased with "breakthroughs".

Anyone with a brain that wants hair is on Fin, everyone else is going to end up bald and disappointed.

I'm not a fan of playing with my hormones but I'd rather suffer mild sides than be "the bald guy".

I also agree with Notgivingup, it will likely be found accidentally during research or medicines treating conditions society actually cares about.

Red Korean seaweed has stopped my hair falling. I use the Purador hair loss therapy shampoo. Oil your hair and massage scalp nightly with coconut oil. Wash in the morning. Watch hair grow

[potato1987]

Red Korean seaweed has stopped my hair falling. I use the Purador hair loss therapy shampoo. Oil your hair and massage scalp nightly with coconut oil. Wash in the morning. Watch hair grow

Where did you find this red korean seaweed?

[Swooping]

Is there any reason you think they are going to fail?

I would not have a sole reason for that.

But looking at their hypothesis;



Read what they say on the right. The consensus about the dermal papilla cells is that they are the master regulator of the hair follicle. The amount of dermal papilla cells is correlated with hair size. The dermal papilla cells exhibit androgen receptor expression. Androgens activate these receptors and that is basically how AGA starts.

Now in a healthy hair follicle cycle the dermal papilla niche moves in telogen and the DP niche loses some size apparently in this phase (a decrease of cells), however it's not much. When the hair cycle is going into an active growing phase again (anagen) the DP niche may recruit some cells from outside the niche.

This re-population might stem from dermal sheath cup cells but we don't know for sure really (first problem).

The second problem also is that these injections would probably need to catch the hair follicle cycle in such an exact manner when the recruitment is actively happening (early anagen). Replicel recently spoke about this too.

Another problem would be then even if you manage to succeed in that, you have probably only replaced a few DP cells and the hair is going into a anagen cycle of 2+ years again. Leaving you with no opportunity to replace these other DP cells.

In a miniaturized unhealthy hair follicle, recruitment isn't even happening and there is a plethora of other problems.

Everything has to be on point for them to succeed.

MPB destroys companies almost as well as it destroys hairlines.

True story lol.