Updated Research and Knowledge - Cutting Edge

[Sogeking]

I'm at 2 weeks now. So far nothing to report. I might be having some decrease is shedding but it might be my wishful thinking. I'll be going with this for 3 months then I'll evaluate my results.

[musky]

+1

[UNBEAT]

anything new??any result using this

[SriHanuman]

Here is what I am using. Vehicle is Eth/Pg/Water and I made 2 concoctions.

First:
- Oleuropein ~0.6mg/ml
- Baicalin ~1mg/ml
- Apple polyphenols ~17mg/ml
- EGCG ~10mg/ml
- Rosemary extract ~1mg/ml
- Rice bran ~0.02mg/ml

I use this in the morning, started a week ago.

Second:
- Oleuropein ~0.6mg/ml
- Baicalin ~1mg/ml
- Fo-Ti ~17mg/ml
- EGCG ~10mg/ml
- Rosemary extract ~1mg/ml

I use this in the evening, started a month ago. There is no minox in any of the concoctions.

Nothing extraordinary to report yet, I maybe seeing more velus hairs and scalp feels great and that's about it for now. I will report back with the experiment if there is any positive results to report about.

[Sogeking]

But why obfuscate the fact it inhibits PGE2 in such a detailed analysis? I can't think of a reason. And haven't cox 2 inhibitors been tried and failed already potentially for this very reason?

Been on the minox approaching 2 months so don't think its causing the shed (although can't be sure).

WEll so far I found that oleuropein is COX-2 inhibitor. By inhibiting COX-2 you can promote hair growth as noted here:

http://cancerres.aacrjournals.org/content/62/9/2516.full.pdf

Also the study that propmted this thread says that it induces anagen hair growth:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462586/

The only place I found that mentions pge2 down regulation is this article (well found another study):

http://download.springer.com/static/pdf/79/art%253A10.1186%252Fs12967-014-0219-9.pdf?originUrl=http%3A%2F%2Ftranslational-medicine.biomedcentral.com%2Farticle%2F10.1186%2Fs12967-014-0219-9&token2=exp=1455557573~acl=%2Fstatic%2Fpdf%2F79%2Fart%25253A10.1186%25252Fs12967-014-0219-9.pdf*~hmac=f21e3868ea4491fbcab02bbb095a16c5ed517ea364f1fc707b8e876be2541258

It has a table with PGE2 and an arrow going down. The reference points to an article:

http://www.sciencedirect.com/science/article/pii/S0955286313001782

IT says that hydroxytyrosol reduced PGE2 after:

The increase in prostaglandin E2 and interleukin 1β after reoxygenation were inhibited after incubation of brain slices with HT and after oral administration

So yeah if it were to reduce PGE2 why did oleuropein show induced anagen hair growth? Maybe the incubation of brain slices had some effect on PGE2 down regulation. Or maybe it was administering it orally?
Too many questions. The article is behind paywall. I'm gonna go with the the newest study about anagen hair growth.
As for results. So far there aren't any for me. But I started on 6th Feb.
Of course if you fear this is not helping you then stop using it. Not trying to be glib here. We actually can't say for sure if this will work. Most of the studies were done in mice so basically we are all live guinea pigs for this. Best of luck mate.

Also I am thinking about adding tea tree oil to my concoction (Eth/PG vehicle with OL, ECGC, Rosemary extract, Apple polyphenols) since it helps with seborrheic dermatitis.

[Phoenix7]

But why obfuscate the fact it inhibits PGE2 in such a detailed analysis? I can't think of a reason. And haven't cox 2 inhibitors been tried and failed already potentially for this very reason?

Been on the minox approaching 2 months so don't think its causing the shed (although can't be sure).

[Sogeking]

Cox-2 inhibition promotes hair growth. Oleuropein is cox-2 inhibitor. In turn by inhibiting cox-2 we are implicitly inhibiting pgd2.
As for shedding. I've been using my mix for a week now. Shedding is the same as pre-use.

Minox is infamous for shedding. Google it. My mix has no minox.

Is it working for me? Not sure yet.

[Phoenix7]

Oleuropein is a cox-2 inhibitor and inhibits PGE2....

Sketchy as **** that this has been left out of chemical's analysis.

[Phoenix7]

What do you mean by this ? what is making this shedding?

I'm undecided. The reflectiveness could have just been the solution. I think I'm getting hairs on hairline that weren't there before, definitely am on the sides of the head. However, the front midsection has gone very thin. Hopefully its a big shed before regrowth.

Anyone shed quite badly on the minox/oleuropein?

[FADI]

This is making my scalp, and area below the hairline shinier... That can't be a good sign, no?

What do you mean by this ? what is making this shedding?

[Phoenix7]

This is making my scalp, and area below the hairline shinier... That can't be a good sign, no?

[FADI]

i read that sheding hairs with a white bulb is due to induction of hair growth cycle, thats mean that the treatment is effective and forcing the hair follicles to start a new growth cycle.

[FADI]

hi chemical what about keto cream you did not indicate it in the treatment protocol?

[FeelsBad]

I'm currently using rosemary leaf extract, teavigo (ECGC), and olive leaf extract (oleuropein) in an ethanol/water vehicle. I have started shedding heavily after a few weeks, and a lot of the hairs have a white bulb at the end. What does this mean? Anyone have thoughts? Should I continue?

[potato1987]

Top work chemical! thank you for the read only post summary! https://www.baldtruthtalk.com/thread...ence-Read-Only