Acceleration in iPS cells clinical applications!!

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  • JayM
    Senior Member
    • Apr 2015
    • 411

    #31
    Read it. It's been explained over 3 pages.

    Comment

    • seanway
      Junior Member
      • Aug 2015
      • 9

      #32
      Originally posted by JayM
      Read it. It's been explained over 3 pages.
      sorry I didnt seen. However, it looks too good to be true.

      Comment

      • nameless
        Senior Member
        • Feb 2013
        • 965

        #33
        Originally posted by joachim
        just had a thought after reading this:
        The Verge is about technology and how it makes us feel. Founded in 2011, we offer our audience everything from breaking news to reviews to award-winning features and investigations, on our site, in video, and in podcasts.


        the white house promises to respond within 60 days from now on, for successfull petitions.

        not that it would change things dramatically, but if we could put up a professionel petition where today's shitty situation with the FDA is clearly explained, also compared to the new laws in japan, we could raise a lot of awareness, and with a bit of luck it could go viral.
        further we would be sure that the white house guys read the stuff and give it some thoughts at least.

        such a petition could change things for the better... but it has to be put up in a professional way.
        i think you, hellouser, have a good sense for such kind of marketing and raising awareness.

        the best case scenario would be, that the U.S. adopts the same laws like japan, at least when it comes to cosmetical procedures.

        just an idea. tell me what you think about it.

        Or better yet we could use a petition to ask the White House to implore the Senate to pass the 21st Century Cures Act in the form that the House turned it over to the US Senator and we could also ask the White House to implore the Senate to wrap it up quickly because people with health conditions want the drug delivery process sped up.

        Comment

        • nameless
          Senior Member
          • Feb 2013
          • 965

          #34
          Originally posted by JayM
          Isn't that almost what the 21st century cure act is doing?
          Yea and we could do a petition asking the White House to ask the US Senate to approve the act in the same form that the House sent it to them and to implore them to approve it fast so we can speed up the process of getting drugs to market.

          But we should not mention which drugs or conditions we are interested in.

          Comment

          • JayM
            Senior Member
            • Apr 2015
            • 411

            #35
            Research team say tiny brain could be used to test drugs and study diseases, but scientific peers urge caution as data on breakthrough kept under wraps


            Just so people understand what funding can do. And what iPSC's can do.

            Comment

            • luiza
              Member
              • Jun 2015
              • 54

              #36
              Originally posted by JayM
              http://www.theguardian.com/science/2...earchers-claim

              Just so people understand what funding can do. And what iPSC's can do.
              How could we do that? We should definitely try.

              Comment

              • JayM
                Senior Member
                • Apr 2015
                • 411

                #37
                What do you mean luiza? We as in hairloss research or we as in grow this brain? because we have already grown it? Look there is still a long way to go but it's always good to gauge where science is right now. In fact if you are looking at it just in a hairloss point of view ignore it all and see that they had 99% of gene expression.

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                • joachim
                  Senior Member
                  • May 2014
                  • 559

                  #38
                  Originally posted by JayM
                  http://www.theguardian.com/science/2...earchers-claim

                  Just so people understand what funding can do. And what iPSC's can do.
                  nice. it's definitely possible to do the same with hair follicles, i mean growing them from iPS. they just have to invest more ressources in it. only a matter of time and effort. iPS grown lab follicles is probably the only real cure, even for nw7. i hope that the russian scientist from sanford&burham keeps working on it, now that they received all the funds they need.

                  Comment

                  • JayM
                    Senior Member
                    • Apr 2015
                    • 411

                    #39
                    Reading more into it, it is the actual method of creating the IPSC they used which is being patented. Exciting times for iPCS's.

                    There are sceptics in the science community and they are also fair because this hasn't been peer reviewed. But to be frank something unpatented with military links isn't going to be until it's solid. Could bode well the military links and their skin/HF work though.

                    Comment

                    • JayM
                      Senior Member
                      • Apr 2015
                      • 411

                      #40
                      Hey guys - Whilst on the subject of stem cells and regen medicine, take a read of this http://www.nature.com/labinvest/jour...t2015103a.html This peptide seems to activate stem cells... so urr would be awesome to see if it had any effect on the hair!

                      I know that the peptide is used in gastrointestinal damage but to target actual stem cells to activate is awesome.

                      Comment

                      • lacazette
                        Senior Member
                        • May 2015
                        • 394

                        #41
                        Interesting! A kind of peptide like that would be perfect to activate our hair stem cells!

                        Few articles I read and little hopeful:

                        Build to precisely control the cell functions at the "artificial circuit" With RNA https://translate.google.com/transla...ml&prev=search

                        "Furthermore, an artificial RNA is introduced into cells in culture on a petri dish, cancer cells only successfully leading to cell death. Precisely detects the state of the cell, because it can control the fate, identification and removal of cancer cells in response to intracellular conditions"

                        "The combination of these artificial circuits, because it can operate the fate of safely and precisely human cells, expected to be closer to the future medical applications."


                        -Using a genome-wide screening approach, scientists from Singapore identified novel regulators of human stem cells differentiation.


                        "While previous studies were mainly performed in mouse embryonic stem cells, data from this work provides a starting point for future studies in the understanding of human embryonic stem cell differentiation. Furthermore, their mechanistic study provided an alternative view on the current understanding of the relationship between stem cell differentiation and cell cycle regulators"

                        "“Knowledge from this screen can be exploited to enhance differentiation protocols used to derive specific cell types from human embryonic stem cells,” Gonzales said."


                        -From pluripotency to totipotency


                        "While it is already possible to obtain in vitro pluripotent cells (i.e., cells capable of generating all tissues of an embryo) from any cell type, researchers have pushed the limits of science even further. They managed to obtain totipotent cells with the same characteristics as those of the earliest embryonic stages and with even more interesting properties. "

                        "Just after fertilization, when the embryo is comprised of only 1 or 2 cells, cells are "totipotent," that is to say, capable of producing an entire embryo as well as the placenta and umbilical cord that accompany it.
                        "For some years, it has been possible to re-programme differentiated cells into pluripotent ones, but not into totipotent cells. Now, the team of Maria-Elena Torres-Padilla has studied the characteristics of totipotent cells of the embryo and found factors capable of inducing a totipotent-like state."

                        Comment

                        • seanway
                          Junior Member
                          • Aug 2015
                          • 9

                          #42
                          Originally posted by JayM
                          Hey guys - Whilst on the subject of stem cells and regen medicine, take a read of this http://www.nature.com/labinvest/jour...t2015103a.html This peptide seems to activate stem cells... so urr would be awesome to see if it had any effect on the hair!

                          I know that the peptide is used in gastrointestinal damage but to target actual stem cells to activate is awesome.
                          I hope this can represent the cure

                          Comment

                          • JayM
                            Senior Member
                            • Apr 2015
                            • 411

                            #43
                            In terms of the peptide - It could be similar to what follicum are producing. Could also explain why they have the ability to kill hair and grow hair with only small changes.

                            Comment

                            • lacazette
                              Senior Member
                              • May 2015
                              • 394

                              #44
                              Yes you right Jaym, follicum seems to be a kind like that.


                              Regarding Singapore researchers, it may be more important that i thought:


                              "Singapore scientists from A*STAR's Genome Institute of Singapore (GIS) have, for the first time, found further evidence of how the differentiation of pluripotent cells is tied to and controlled by the cell cycle clock. This deeper understanding of how cells become differentiated is extremely important when considering therapeutic potentials."

                              There's a national skin center in Singapore and a research area regarding hair biology and regeneration:



                              Hair Biology and regeneration is a new niche area of research for NSC given its high prevalence and clinical relevance. The core aims to establish a cohort of patients with various hair diseases for genetic, epidemiological and clinical research .

                              It could be interesting there, aswell as South korea with sung jan li, who recently induced hair follicle neogenesis without the help of inductive hair follicle dermal papilla cells or newborn dermal cells:

                              Comment

                              • JayM
                                Senior Member
                                • Apr 2015
                                • 411

                                #45
                                http://www.medicalnewstoday.com/releases/298753.php some good news for iPSC's

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