US government owned patent on hair follicle neogensis

[lacazette]

lacazette i just applied i live 100 miles away. thank you. i dont know what will happen, but i feel so greatful it's been 10 years of searching the internet being picked on and made fun of by people. if this works out i'm going to paypal you $1,000 ... definitely not joking, i'm so impressed with all you guys how far, fast, and deep you all dig. i have a twin brother were identical I want to sign him up too but I know they will placebo one of us and that will be too painful to experience so i'm going to refrain mentioning him, pretty sad about that ~ will let you all know if i get a response and what happens, will post my own pics here too if i get in.

so good for you bro! you're welcome we're all in the same boat! I hope they'll accept you in the trial !
I think you'll sign a contract something like that, and you won't be able to share any pictures , or give us infos on what's happening, even if it's working great
But i think you could give us little infos like which phase it is, in what consist the protocol, number of participants etc.. little things like that, and it's already great!!

All that 'US army research' sounds really really really promising.
2014 They claim in the patent they have the solution
2015 they are enrolling for clinical trial to confirm it

We were afraid that we will have to wait the all skin graft trials before they think about us. But no, that's not the case!!

this fabulous quote from the patent will become my new signature haha :

"[089] The invention also provides a pharmaceutical composition comprising human dermal papilla cells and human keratinocytes, optionally in combination with collagen, for use in treating a subject who is at risk for, diagnosed with, or who has hair loss or is in need of hair follicle neogenesis"


Hey Jay! yes for sure I will ask him about this in the mail. I hope he will answer and give the very few infos that he is able to give. Will try the other two scientists as well

[jpar]

lacazette i just applied i live 100 miles away. thank you. i dont know what will happen, but i feel so greatful it's been 10 years of searching the internet being picked on and made fun of by people. if this works out i'm going to paypal you $1,000 ... definitely not joking, i'm so impressed with all you guys how far, fast, and deep you all dig. i have a twin brother were identical I want to sign him up too but I know they will placebo one of us and that will be too painful to experience so i'm going to refrain mentioning him, pretty sad about that ~ will let you all know if i get a response and what happens, will post my own pics here too if i get in.

[JayM]

Side note: Lacazette ask him about this trial when you email him? Just casually throw it in there haha. Thanks again for doing all this work!

And Renee and everyone else of course

[lacazette]

Renee
guess who was a participant of the 'Regenerative Medicine Essentials' organised by Wake Forest in 2013?
yes the answer is Rajesh Thangapazham! ^^

"Rajesh Thangapazham @RAJ_SR · 21 juil.
Started #rmessentials"

My god I wish I live near them to participate this trial! Sounds promising as hell

[lacazette]

Oh wow! Wake forest is one of the institutions that is involved with usa government in researching regenerative medicine. I wonder if this trial has to do anything with any of the patents?

For sure in my opinion dude!!the military medical institutions are collaborating and are all under US Army research entitie. I'm sure those findings in these patents help to lead to that beginning trial !

@hemo :

"[089] The invention also provides a pharmaceutical composition comprising human dermal papilla cells and human keratinocytes, optionally in combination with collagen, for use in treating a subject who is at risk for, diagnosed with, or who has hair loss or is in need of hair follicle neogenesis"

[Renee]

Oh wow! Wake forest is one of the institutions that is involved with usa government in researching regenerative medicine. I wonder if this trial has to do anything with any of the patents?

[Hemo]

Just curious, how do you know that's the same treatment? Pages 2 and 3 of the thread won't load for me.

[lacazette]

Guys!!!
they are enrolling people RIGHT NOW for a MPB trial!!!!!

Study Using a Topical Investigational Medication for the Treatment of Male Pattern Hair Loss

http://www.wakehealth.edu/BeInvolved...70&title=Study Using a Topical Investigational Medication for the Treatment of Male Pattern Hair Loss

OMFG

[Sogeking]

Sogeking, how do you know they are not in a hurry to commercialize it? Or did you just make that up? There are thousands of soldiers that need this cure for quality of life.

I am not questioning the need for this for hair follicle neogenesis, or even the benefit or making new skin itself. It would be much needed not just to soldiers.
However the last patent has been filed in 2014. This is what it says:

This invention was made in part with support from the U.S. Government. Accordingly, the Government has certain rights in this invention.

We have no idea when the Government will move and allow creation of a company(startup) to commercialize this. Also I was referring to skin itself, they did move hair follicle grafts but they used skin substitutes not skin itself as noted:

Skin Substitutes: Three-dimensional in vitro constructs were prepared for grafting using established methods modified as described herein. Briefly, human dermal papilla cells were mixed with 1 mg/ml type I collagen (rat) (in other embodiments, the collagen could be bovine) in 10% FBS/DMEM, and added to 6 well transwell plates (Corning Incorporated, Coming, NY) at a density of 1 .5 X 105 cells per cm2. The dermal equivalents were cultured in 10% FBS/DMEM for 4 days before aliquoting 1 X 106 keratinocytes on top. The constructs were cultured submerged for 2 days in a mixture of DMEM and Ham's F12 (3:1) (GIBCO/lnvitrogen, Grand Island, NY) containing 0.1 % FBS, after which the keraiinocytes were brought to the air-liquid interface and cultured in a mixture of DMEM and Ham's F12 (3:1 ) containing 1 % FBS for another 2 days before grafting.

That said what we really miss, at least what I miss are tables at the end which are not visible at the link given. That said they did get some notable results:

Figs. 16A-C show that different hair follicle stages could be detected in grafts after 15 weeks. The grafts containing dermal papilla cells grown in monolayers, and those grown as spheroids, had telogen hair follicles, confirmed by club-like appearance and spiky keratin fibers (see Fig. 16A), secondary hair germ with adjacent hair papilla (see Fig. 16B, arrow), and a cornified club (see Fig. 16C, negative for toluidine blue staining, arrow). Telogen hair follicles showed no Ki-67 positive cells, consistent with telogen stage of hair follicle (Fig. 17A, arrow). An anagen hair follicle (Fig. 17B, arrow) with dermal papilla from the same section as the telogen hair follicle shows dense Ki-67 reactivity in matrix, as expected.

However they are still taking human dermal papilla cells and implanting them into bald rats. This is all early stage research. As I said 2-20 years we can't really know. If it were a commercial company they would have incentive to get the funds and rush it to be approved by FDA.Since the US government is involved we don't know in what manner or speed things will progress from lab to market.

[TooMuchHairWontKillYou]

Will it be a pill or some kind of surgery?

[lacazette]

The lead scientists email is: rajesh.thangapazham@usuhs.edu I have no idea what I'm really asking haha. Does anyone with a better understanding want to see if we can get anything?

good jay! we could ask him simple questions or confirmations on some details. I doubt he will answer but it costs nothing hehe I will try tomorrow

[lacazette]

From articles about army skin regenerative developpment

"This type of technology is particularly pertinent for the US military, as burns account for 30 percent of injuries endured by soldiers on the battlefield. Add to this, the number of soldiers who are surviving previously fatal injuries; there is now a renewed effort to develop innovative treatments to improve the care of injured service personnel.

"“One of the most urgent requests from both burn patients and their care providers is to eliminate the need for (previous) skin grafts.”

"“Severe burns can ruin a life, so there is a desperate need.”

Yes renee I think also it will go fast for burned disfigured soldiers, and then for civil ones.
Their methods for hair loss sufferers will come later, but not that much, since the major issues about FDA things will be already resolved.

We are really Lucky, cause as they said, the most crucial point that was missing for a new functional skin was the hair follicle neogenesis that induce normal HF.
So US army research worked exactly on the point that we, hair loss sufferers, needed

@Sogeking just read again and keep cool

[089] The invention also provides a pharmaceutical composition comprising human dermal papilla cells and human keratinocytes, optionally in combination with collagen, for use in treating a subject who is at risk for, diagnosed with, or who has hair loss or is in need of hair follicle neogenesis

[JayM]

The lead scientists email is: rajesh.thangapazham@usuhs.edu I have no idea what I'm really asking haha. Does anyone with a better understanding want to see if we can get anything?

[Renee]

Sogeking, how do you know they are not in a hurry to commercialize it? Or did you just make that up? There are thousands of soldiers that need this cure for quality of life.

[JayM]

Plus they said that they are in clinical trials using this patented technology.