Where are the phase IIb results for Bimatoprost?

[rdawg]

Encouraging would be to see the Bimatoprost results. Doesn't look like anyone cares.

"Blume-Peytavi et al23 performed a randomized,
double-blind, placebo-controlled pilot study of
16 men with androgenetic alopecia, applying
topical latanoprost 0.1% daily on the right or left
frontotemporal mini-zones. After 24 weeks of treatment,
the latanoprost-treated site demonstrated a
significant increase in hair density compared with
baseline (P \ .001) and placebo site (P = .0004). Besides a localized erythematous reaction, no
adverse events were reported. Despite these
findings, in a case report of a woman with female
pattern hair loss treated with injected bimatoprost, a
similar response was not seen.24"

i'd say that's pretty encouraging. positive response and no adverse affects at 0.1% solution, Isn't bim using a 1-3% solution?

[It's2014ComeOnAlready]

Yeah, here's a quote from their patent, filed in feb 14, published in Oct 14: "The preferred bimatoprost concentration range is about 2-4% w/w, more preferably about 2.5-3.5% w/w. These preferred bimatoprost concentration ranges allow a surprisingly good balance to be achieved between the wanted pharmacologic effects of the composition and any unwanted side-effects. It had previously been thought that bimatoprost compositions for stimulating growth of hair should have a much lower bimatoprost concentration; this has now surprisingly been found not to be the case."

[rdawg]

Yeah, here's a quote from their patent, filed in feb 14, published in Oct 14: "The preferred bimatoprost concentration range is about 2-4% w/w, more preferably about 2.5-3.5% w/w. These preferred bimatoprost concentration ranges allow a surprisingly good balance to be achieved between the wanted pharmacologic effects of the composition and any unwanted side-effects. It had previously been thought that bimatoprost compositions for stimulating growth of hair should have a much lower bimatoprost concentration; this has now surprisingly been found not to be the case."

Even more positive, it seems the higher the dose the better response, and they've found the best % with the lowest amount of sides.

What would hold them back from pushing this forward, the only thing I can think of is that the results were good, but not amazing(lets say, 5-10% better than minoxidil) and they just aren't willing to put out a product unless it's a significant improvement. Hopefully that's not the case.

[breakbot]

Like I've stated earlier, phase 2b success has the implication of a phase 3 and a launch. It would pretty much be letting the cat out of the bag. Being quiet, while continuing the study (it says "this study is ongoing but not recruiting participants" on clinicaltrials.gov) ensures that when it is time to announce success, you actually HAVE a product to market. It makes no sense to announce results now, the stock is doing fine on its own. Yes, normally good news is released at the time it occurs, but given what's happened with this company recently, it actually makes sense to hold back.

As the saying goes: "no news is good news."

https://clinicaltrials.gov/ct2/show/NCT01904721

This study has been completed.
What's your next move?

[BiqqieSmalls]

Even more positive, it seems the higher the dose the better response, and they've found the best % with the lowest amount of sides.

What would hold them back from pushing this forward, the only thing I can think of is that the results were good, but not amazing(lets say, 5-10% better than minoxidil) and they just aren't willing to put out a product unless it's a significant improvement. Hopefully that's not the case.

They have so much going on between the merger that posting the results of Bim is not on their high priority list. Let it play out man.

[It's2014ComeOnAlready]

https://clinicaltrials.gov/ct2/show/NCT01904721
This study has been completed.
What's your next move?

Yea, that's about phase 2b, they did complete that study. Do you want a cookie?

My next move... is this thread about you? I'm not up against anyone, maybe you think you're my opponent or something haha. I've shown in the thread many times that this drug works very well. My enthusiasm comes from that. They could be in phase 3 right now for all we know. They don't have to post anything to clinicaltrials.gov yet because their patients were already enough patients enrolled from previous studies. We don't know what the status is! I hope they are continuing, we'll just have to wait and see.

[Keki]

https://clinicaltrials.gov/ct2/show/NCT01904721
This study has been completed.
What's your next move?

*facepalm*

I wonder why are always the same people in every thread...

[sascha]

You know what we should send a mail to che ceo or someone like that explaining the enthusiasm and hope on bim, ...

Did you do that? I thinks its worth a shot or maybe somebody could call in the next show and just ask.
This thread becomes so disturbing to read. It would be a shame if this stuff would not work, but even a bigger shame if we keep talking about it if it does not.

[Keki]

No i didn't, they will trash my mail if alone, for this reason i asked a community thing, but people focus on flaming eachother istead, basically now everyone who post some sort of positive behevior or some slightly good paper are marked as dreamer, idiot and blind hype follower, nothign costructive, this is no news the hairloss community if full of fustrated people, we can't do a shit, soon someone will quote my idea as "useless cuz the evil corp doesn't give a shit about aga and balding people", just wait

[sascha]

I agree Keki this is not the right attitude to tackle a problem. Well do you know somebody who could possibly call in the Bald Truth or just somebody else who reads this(Artista)? I would do it, but I live in Italy and that is kind of inconvenient. I would love to hear 2014 calling in, since I think he would not be satisfied with the "yeah we just have to wait"-crap, and that is most likely the answer for somebody who is not persistant ...
I miss Joe from SI because of this very reason. Love him or hate him but he made sure that 10 - 15 minutes of the show are reserved for the future.

[breakbot]

Yea, that's about phase 2b, they did complete that study. Do you want a cookie?

My next move... is this thread about you? I'm not up against anyone, maybe you think you're my opponent or something haha. I've shown in the thread many times that this drug works very well. My enthusiasm comes from that. They could be in phase 3 right now for all we know. They don't have to post anything to clinicaltrials.gov yet because their patients were already enough patients enrolled from previous studies. We don't know what the status is! I hope they are continuing, we'll just have to wait and see.

No you are not my opponent. I just as you want bimatoprost to move on. But i don't think so, unfortunately.

[Illusion]

We could send emails out yeah. I doubt it will do anything but it requires almost zero effort so if we can get a lot of people to do this then why the hell not. But having someone "big" in the community reaching out would be even better I think. What about Spencer? Does he know anything about Bim? Sorry if this has been mentioned before in this thread or if he already talked about this on his show (I never watch his show )

[rdawg]

We could send emails out yeah. I doubt it will do anything but it requires almost zero effort so if we can get a lot of people to do this then why the hell not. But having someone "big" in the community reaching out would be even better I think. What about Spencer? Does he know anything about Bim? Sorry if this has been mentioned before in this thread or if he already talked about this on his show (I never watch his show )

yes he knows about BIM and mentioned that he heard the 2B trials were going well back in one of his shows around December I believe.

[bornthisway]

A dermatologist office that claims to work closely with Allergan said they were bringing a product based on Latisse to market for hair loss very soon, like this Summer. Which isn't possible based on where it is in the trials... if only.

[Keki]

A dermatologist office that claims to work closely with Allergan said they were bringing a product based on Latisse to market for hair loss very soon, like this Summer. Which isn't possible based on where it is in the trials... if only.

ya well i don't think they can skip phase3 anyway so pretty sure is bullshit