follicept - what's this?

[Dimoxynil]

http://www.gainesville.com/article/2...9735?p=2&tc=pg

This article says that they hope to release it to the market this fall

But if that's the case, then when do they plan to do the human trials?

These trials would have to begin very soon and last only for few months (Fall is from September 23rd to December 21st)

So what would such short trials tell us about efficacy and, more importantly, safety of that drug?

Besides, even in rats these results don't look impressive at all. They just grew some irrelevant fluff that you can't really call terminal hair, so I don't know why people are so excited about it?

We saw MUCH better results on rats/mice in the past, and still no human treatments came out of it. It just looks that baldness in mice/rats is too much different from MPB in humans, so I wouldn't be surprised if Follicept fails.



I'm not trying to be negative, just realistic

Lol the light in pictures 2 + 3 look brighter to show more hair. I would love to be optimistic on this but let's face it. This is something barely worth keeping an eye on.

[Hairismylife]

Keep our eyes on Bim please…

[burtandernie]

It seems odd to me anyone still tests MPB stuff on mice instead of stump tailed macaque that much more closely resembles a human because mice have so many differences what is even the point when it doesnt tell you anything anyways?
Someday it would be nice if the layers of skin epidermal,dermal could be grown in the lab and you could simply buy that and test hair on actual scalp tissue without needing an actual person. Yes blood flow and some things are different than but its still a pretty accurate test compared to mice

[liba]

No problem, you guys have been 99.9% awesome and have given us some awesome info. Working to get trials started ASAP and get some results so we can all breathe easier!

Devon please keep us updated!!

[runrunrun]

Is that really feasible?? Although they said it will be able to release this fall but i cannot believe because of lack of time.
I wish follicept is not snake oil but...I think developers are too optimistic. What do you think? (I am korean and I am not a good English speaker.. plz understand my poor English use ability haha)

[EXprettyboy]

It normally takes longer because medications are required to undergo clinical trials by the FDA, but this has been classed as a cosmetic and so it can be launched immediately.


Prometheon pharma upgraded their website and it looks slick, and the follicept logo is pretty cool too. The marketing direction they're taking looks about right to me, starting with solid scientific theory then delivering the "one two combo" to the competition. But can they execute the knock out punch with some real evidence? I for one am out of my seat...

Local application provides a barely detectable dose of insulin-like growth factor 1 (IGF-1) to dormant cells in the dermal papillae of small inactive hair follicles, physiologically stimulating hair regrowth, normalization of the hair growth cycle, and the reversal of AGA. This formulation avoids the shedding phenomenon and other side effects such as darkened eye bags associated with topical minoxidil. Follicept™ is not associated with impotence, the major side effect of finasteride.

[cookies]

This sounds interesting, but I'm sceptical. MPB in humans is far more complex (and probably more difficult to treat) than a rat with hairloss due to a single mutation.

Furthermore, I'm wodering why Follicept has chosen to go public with this already when they haven't even started testing it. If it doesn't work, the reputation of the company behind Follicept will be tarnished, thousends will be dissapointed and Follicept can expect an inbox full of hatemail probably. So why the rush?

[youngin]

Lol the light in pictures 2 + 3 look brighter to show more hair. I would love to be optimistic on this but let's face it. This is something barely worth keeping an eye on.

lol more light and more zoom. you can see where the lumps are in comparison. 1-3 keeps zooming. fail

[DanWS]

Have to agree with the points made about the lighting and zoom in the photos. They're very inconsistent. The ones taken for the human trials must be much better.

[Jonathan]

The reason with the images is to show the efficiency of Follicept after stop of using it. This is shown in image 3 (the progress between image 2 and 3). In image 2 Propecia is even better than Follicept but that is irrelevant.

If they wanted to "cheat" for any reason they would only add lightning to image 3. There is absolutely no reason for Follicept to change the lighting in both image 2 and 3. It is a coincident. So please stop with your conspiracy theories

[Chromeo]

lol more light and more zoom. you can see where the lumps are in comparison. 1-3 keeps zooming. fail

Wrong: 3 is actually less zoomed than 1.

[hairderp]

i think that's a better pic. Both follicept and rogaine have the same lighting

[Parsia]

i think that's a better pic. Both follicept and rogaine have the same lighting

I'm sorry to say that but I think its pointless to talk about rats results ! thanks for posting the pic again but just look at Rogaine in 2nd pic after 26 days , there are some regrowth and then you won't see them after 39 days , why ? the density is less in 3rd pic in compare with 2nd pic for rogaine , it is maybe because its on rats not humans ! and its better if we just wait and see what is the result of follicept on human !

[RGPHILPA]

Why would they show "efficacy" after stopping the treatment? And "results" after only 26 days. Rogaine does not work on that time scale. And where is the proper control group? Without that, it's impossible to say anything about these "results". These photos are so amateurish, unscientific and ridiculous it's almost not worth commenting on.

Prediction: the clinical trials the supposedly are going to run - you'll never see proper results from them. That carrot will be dangled before you forever and never delivered. We'll start to see new posters show up here who are in the trials and can't really talk too much about details, but, they'll swear they see a slow down in shedding and possibly, (but not for sure!) see some regrowth.

[Dimoxynil]

Why would they show "efficacy" after stopping the treatment? And "results" after only 26 days. Rogaine does not work on that time scale. And where is the proper control group? Without that, it's impossible to say anything about these "results". These photos are so amateurish, unscientific and ridiculous it's almost not worth commenting on.

Prediction: the clinical trials the supposedly are going to run - you'll never see proper results from them. That carrot will be dangled before you forever and never delivered. We'll start to see new posters show up here who are in the trials and can't really talk too much about details, but, they'll swear they see a slow down in shedding and possibly, (but not for sure!) see some regrowth.

I massively agree with this. WE as consumers have to set the bar high (definite maintenance and definite re-growth.) the producers of these drugs need to meet our expectations or fall slightly below them(but produce good results) to claim a single penny from me.