2015- Make or Break Future Treatments

[Jasari]

It's amazing that hair loss still exists in an age where the sufferers grew up with Pokemon.

[FearTheLoss]

This thread made me laugh!
Brief history lesson:
Only two effective treatments so far are Minoxidil and Finasteride.
Minoxidil was discovered by accident by doctors who were using Minoxidil to treat hypertension.
Finasteride was discovered by accident in the process of treating BPH.

Possible future treatments:
Bimatoprost was discovered accidentally through the treatment of glaucoma. Even after its discovery the pharma companies thought it was more important for women to have longer, fuller eye lashes. That in itself shows how little regard they have for MPB sufferers.

What you need to understand is that MPB research doesn't exactly attract the cream of the crop of medical researchers. The talented ones will be drawn to other more academically fulfilling fields, eg. Cancer.

Seriously, what have the 'researchers' who are only concerned with MPB achieved in terms of bringing anything viable to the market with decades of study - Nothing!

People shouldn't be waiting for the MPB researchers to have a break through but instead they should be praying that some doctor or researcher working in another field stumbles onto something relevant. These guys are our only hope.

Rant over!

It's ignorant to think that because the two available treatments we have now were discovered by accident that the future only holds promise to accidental discovery as well. For someone to suggest that, ignoring all of the recent discoveries and the researches who are trying to tap into a billion dollar industry is pure stupidity. Our knowledge of the human body, as well as medical technology, is advancing at a pace faster than ever before and it continues to accelerate.

[sdsurfin]

They didn't know much about the pathways that induce hairloss until very recently. Wnt and PgD2 pathways were recently discovered to be involved, and now there are two drugs being trialled for those pathways. The next big hair loss drug will not be an accident, id bet anything on it. However, drugs in general are not the solution to a condition that is influenced by so many things, and is truly very complex. Stem cells and genetic engineering are the answers but they'll take a few more decades to really pan out in a way that is useful. It may be a prediction, but it's an informed one based on the usual timelines. I'm excited about replicel and Sm, but maybe neither will pan out, it's a toss up I think, but both are steps in the right direction.

[FearTheLoss]

They didn't know much about the pathways that induce hairloss until very recently. Wnt and PgD2 pathways were recently discovered to be involved, and now there are two drugs being trialled for those pathways. The next big hair loss drug will not be an accident, id bet anything on it. However, drugs in general are not the solution to a condition that is influenced by so many things, and is truly very complex. Stem cells and genetic engineering are the answers but they'll take a few more decades to really pan out in a way that is useful. It may be a prediction, but it's an informed one based on the usual timelines. I'm excited about replicel and Sm, but maybe neither will pan out, it's a toss up I think, but both are steps in the right direction.

I agree completely. I believe in the next 5 years or so we will undoubtedly have something better than minox and fin. However, the real cure will not be a drug. I would bet 10-20 years until one hits the market, realistically. Although, we can hope for the best and I hope I'm wrong and it comes out sooner.

[It's2014ComeOnAlready]

They didn't know much about the pathways that induce hairloss until very recently. Wnt and PgD2 pathways were recently discovered to be involved, and now there are two drugs being trialled for those pathways. The next big hair loss drug will not be an accident, id bet anything on it. However, drugs in general are not the solution to a condition that is influenced by so many things, and is truly very complex. Stem cells and genetic engineering are the answers but they'll take a few more decades to really pan out in a way that is useful. It may be a prediction, but it's an informed one based on the usual timelines. I'm excited about replicel and Sm, but maybe neither will pan out, it's a toss up I think, but both are steps in the right direction.

I agree as well, however PGD2 was discovered in 2007, maybe even earlier. Not exactly recent, but i suppose it is in terms of hair loss research.

[TotallyScrewed]

I agree completely. I believe in the next 5 years or so we will undoubtedly have something better than minox and fin. However, the real cure will not be a drug. I would bet 10-20 years until one hits the market, realistically. Although, we can hope for the best and I hope I'm wrong and it comes out sooner.

A stem-cell based cure for baldness is already in the works by scientists..

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116892

[hosney7]

Aaron gardner said here before that one team breaks the problem it will process rapidly
It seems
Tissuse of Lauster is now absorbed in bio chip
Cumc of Christiano - AA
Durham of Jahoda & Aaron - adipose
Taiwanese - veiled (if it works then they can terminate the situation)
Tsuji - lost
Russian team - controversial
Replicel - close to the market but its efficiency is doubtful

Just my thoughts

[Trenblastoise]

A stem-cell based cure for baldness is already in the works by scientists..

http://journals.plos.org/plosone/art...l.pone.0116892

Indeed it is being researched. It will take a lot of time. The hairs these scientists made were micro hairs as far as I understood, they are too weak to break through the skin.

When they get to that point they will have to go through trials. So we are most likely looking at, as the guy you are quoting said, 10-20years or so. I think we are justified based on the evidence to be optimistic in the long run.

[tedwuji]

whats going on with PiloFocus? Specifically what happened at Dr Wesleys recent presentation? does anyone know?

http://www.drcarloswesley.com/updates.html

[Swooping]

To be honest shot term 0-10 years it is looking incredibly bad. The only positive side about it all is that we are rapidly advancing in understanding AGA, advancing in cell culture and drug screening models. Oh well, at least the kids from now won't have much to worry about.

[Tenma]

To be honest shot term 0-10 years it is looking incredibly bad. The only positive side about it all is that we are rapidly advancing in understanding AGA, advancing in cell culture and drug screening models. Oh well, at least the kids from now won't have much to worry about.

yeah. we are probably the maintenance generation lol. those who started losing their hair before the 2000s didnt have shit. but is ddepressing the lack of success on the regrowth corner. i still have some faith in sm though

[mikes23]

I think it's look incredible bad for replicel, histogen, and pilofocus. But I still have hope with Dr Lauster or one of these universities working on 3d printing. I think in 2016 or 2017 will see something big from dr lauster. If lauster solves it next year, then we can have the cure out in a few years if they partner with someone in Japan but idk if he will do that since he works for the university. If an American University solves it then we aren't seeing a cure before 2025. I think 2016 is our make or break year. This will tell us more what is going to happen to histogen, replicel, and pilofocus. Also the taiwanese will be done with whatever trial they had in 2016. I believe the cure is solved this decade, depending on which team solves it will dictate how soon it comes out.

[FearTheLoss]

I think it's look incredible bad for replicel, histogen, and pilofocus. But I still have hope with Dr Lauster or one of these universities working on 3d printing. I think in 2016 or 2017 will see something big from dr lauster. If lauster solves it next year, then we can have the cure out in a few years if they partner with someone in Japan but idk if he will do that since he works for the university. If an American University solves it then we aren't seeing a cure before 2025. I think 2016 is our make or break year. This will tell us more what is going to happen to histogen, replicel, and pilofocus. Also the taiwanese will be done with whatever trial they had in 2016. I believe the cure is solved this decade, depending on which team solves it will dictate how soon it comes out.

I agree with you in terms of the cure coming to market. However, I disagree when it comes to replicel and pilofocus. I think we will see 30-50% consistent regeneration from pilofocus with improved speed as opposed to FUE. I think Replicel will prove to be maintenance plus 30% regrowth. I think histogen is a bust.

I also think we will see better results from PRP therapy.

[joachim]

I agree with you in terms of the cure coming to market. However, I disagree when it comes to replicel and pilofocus. I think we will see 30-50% consistent regeneration from pilofocus with improved speed as opposed to FUE. I think Replicel will prove to be maintenance plus 30% regrowth. I think histogen is a bust.

I also think we will see better results from PRP therapy.

lol. 30 to 50% regeneration. NO WAY. this would practically be the cure as it is true hair multiplication then. pilofocus will do nothing but dissapoint. let's hope i'm wrong.

[FearTheLoss]

lol. 30 to 50% regeneration. NO WAY. this would practically be the cure as it is true hair multiplication then. pilofocus will do nothing but dissapoint. let's hope i'm wrong.

I'm almost positive it will have more than 20% for sure. Look at the science that backs it up, and look at the results some doctors have gotten, such as Dr. Cole. I think Dr. Cole stated somewhere on here that the reason it's hard to get the regeneration to be consistent is because ACell leaks. If Dr. Wesley is putting it under the skin where the follicles are extracted, it would be where it needs to be. HENCE REGENERATION!