2015- Make or Break Future Treatments

[Swooping]

While searching online for more info about RK-023, I came across this press release about a Androgenic Alopecia Therapeutic Companies and Drugs Pipeline H2 2014 Review Research Report: http://www.cnbc.com/id/102280929#.

It mentions some drugs that at least I had never heard of, such as RES-440:



You can buy the report here: http://www.rnrmarketresearch.com/and...et-report.html, but it's 2000 dollars.

Anyone now bit more info what compound that is?

[tiktok]

Anyone now bit more info what compound that is?

Google is your friend:

"RES-440, a carboxylic acid ester of hydroxyflutamide, is a synthetic, non-steroidal compound and represents one of four structural classes of topical anti-androgenic compounds in the RestorGenex portfolio. Management believes RES-440 is the first topical anti-androgen engineered for rapid deactivation by hydrolytic enzymes near the site of application to a single inactive metabolite, thus, sparing internal androgen sensitive tissues. Our data demonstrate that RES-440 is a very potent anti-androgen. RES-440, the expected major metabolite, has no detectable anti-androgenic activity. To date, no other topical anti-androgen has been developed and marketed successfully. We believe the root cause of this failure has been due to the systemic safety issues that arise with locally effective doses. " - http://www.restorgenex.com/products_res440.cfm

[Illusion]

To date, no other topical anti-androgen has been developed and marketed successfully. We believe the root cause of this failure has been due to the systemic safety issues that arise with locally effective doses.

Reading things like these always freak me out a bit as I'm on RU. Man, if only I could contact the researches that were researching RU at the time to ask why they didn't push through... I tried searching them on google and even on Linked In, but didn't really find anything. I just hope the reasons for not pushing through had to do with finances and not with efficacy or safety issues

[Alex88]

i'm crossing whatever i can. i'm pretty much done with my donor area at 26,so .....

[It's2014ComeOnAlready]

In 2015, I'm hoping BIM gets approved for hair loss. If that is so, it would prove a lot with regards to prostaglandins and hair loss in a product. I think we would also eventually see other products related to this technology, changing how we treat hair loss. No more propecia, no more rogaine.

Out with the old, in with the new in 2015!

[Sogeking]

Google is your friend:

"RES-440, a carboxylic acid ester of hydroxyflutamide, is a synthetic, non-steroidal compound and represents one of four structural classes of topical anti-androgenic compounds in the RestorGenex portfolio. Management believes RES-440 is the first topical anti-androgen engineered for rapid deactivation by hydrolytic enzymes near the site of application to a single inactive metabolite, thus, sparing internal androgen sensitive tissues. Our data demonstrate that RES-440 is a very potent anti-androgen. RES-440, the expected major metabolite, has no detectable anti-androgenic activity. To date, no other topical anti-androgen has been developed and marketed successfully. We believe the root cause of this failure has been due to the systemic safety issues that arise with locally effective doses. " - http://www.restorgenex.com/products_res440.cfm

It seems they are starting acne trials next year. To be frank unless this is really effective we can get the same from CB more or less.

[Swooping]

Google is your friend:

"RES-440, a carboxylic acid ester of hydroxyflutamide, is a synthetic, non-steroidal compound and represents one of four structural classes of topical anti-androgenic compounds in the RestorGenex portfolio. Management believes RES-440 is the first topical anti-androgen engineered for rapid deactivation by hydrolytic enzymes near the site of application to a single inactive metabolite, thus, sparing internal androgen sensitive tissues. Our data demonstrate that RES-440 is a very potent anti-androgen. RES-440, the expected major metabolite, has no detectable anti-androgenic activity. To date, no other topical anti-androgen has been developed and marketed successfully. We believe the root cause of this failure has been due to the systemic safety issues that arise with locally effective doses. " - http://www.restorgenex.com/products_res440.cfm

Was meaning RK-023 sorry but already found it thanks!!

[Trouse5858]

Would it be beneficial to use bim as well as cb, or do they essentially work via the same mechanism? I'd gladly swap out my RU and rogaine combo for a more effective 1-2 punch, topical or not.

[cookies]

Was meaning RK-023 sorry but already found it thanks!!

There was a thread about it a while ago: https://www.baldtruthtalk.com/showth...t-%28RK-023%29

Too bad RES-440 is being developed for acne (ugh), but I wonder how it did end up in the report on Androgenic Alopecia.

[Coizi]

CB-03-01 is not for tomorrow or next year my friends sended them an email il copy the most relevant answers

The clinical trails for CB-03-01 phase 3 acne will start this year i assume right? yes
but will there be a clinical trail phase 3 for the same compound for alopecia or will there be an accelerated procedure (approval based on surrogate markers)? The alopecia trials is for the same compound but a different formulation and that requires a full clinical trial

also phase 3 will start in 2016 +-1year then we got fda review +- 1year so cb release date is 2018-2019 if anything goes normal !

[hellouser]

CB-03-01 is not for tomorrow or next year my friends sended them an email il copy the most relevant answers

The clinical trails for CB-03-01 phase 3 acne will start this year i assume right? yes
but will there be a clinical trail phase 3 for the same compound for alopecia or will there be an accelerated procedure (approval based on surrogate markers)? The alopecia trials is for the same compound but a different formulation and that requires a full clinical trial

also phase 3 will start in 2016 +-1year then we got fda review +- 1year so cb release date is 2018-2019 if anything goes normal !

If we can at least get an idea of the formulation and concentration, we should be able to get CB via other methods before its alopecia release.

[Trenblastoise]

What do you guys have the highest hopes for? I'm excited for Pilofocus and Bim!

I have the most confidence in stem cell research. I don't care about pills that mess up hormone levels or give you temporarily results, I care about an actual cure. And this is a field that can cure it.

The first step:
They have managed to convert human skin cells into induced pluripotent stem cells (iPSCs) by adding three genes, these can change into any cell types in the body.

The Second step:
I'd say is to create the complete follicles.
So far they haven't managed to create all the different cells to do this, tho they have managed to create epithelial stem cells, which are found in part of hair follicles.
They have also managed to turn the iPSC into keratinocytes, which is the main cells in the top layer of the skin.

The Third step:
They haven't figured to make dermal papillae, which is the second type of cells part of the hair follicle as far as I understood Dr. Xu.

The Fourth step:
Successfully carry it out in practice.

If anyone got more information on this, please link me to it, I'd like to read it to understand the position better. Who knows how much time they will need? 5 years? 10 years? I certainly hope it's been done before 10 years. In the meantime I suppose I should continue looking into FUE transplant so I got something in the gap. My hair loss is rather slow, I think FUE can help me out for 10-15 years.

[Arashi]

I have the most confidence in stem cell research. I don't care about pills that mess up hormone levels or give you temporarily results, I care about an actual cure. And this is a field that can cure it.

The first step:
They have managed to convert human skin cells into induced pluripotent stem cells (iPSCs) by adding three genes, these can change into any cell types in the body.

The Second step:
I'd say is to create the complete follicles.
So far they haven't managed to create all the different cells to do this, tho they have managed to create epithelial stem cells, which are found in part of hair follicles.
They have also managed to turn the iPSC into keratinocytes, which is the main cells in the top layer of the skin.

The Third step:
They haven't figured to make dermal papillae, which is the second type of cells part of the hair follicle as far as I understood Dr. Xu.

The Fourth step:
Successfully carry it out in practice.

If anyone got more information on this, please link me to it, I'd like to read it to understand the position better. Who knows how much time they will need? 5 years? 10 years? I certainly hope it's been done before 10 years. In the meantime I suppose I should continue looking into FUE transplant so I got something in the gap. My hair loss is rather slow, I think FUE can help me out for 10-15 years.

There's tons of info on this subject on this board, especially read the posts from Dr Gardner.

Anyway in a nutshell: it took them 35 years to figure out how to culture DP cells while retaining their hair inducing capability. Now they have figured that SOMEWHAT out, they can now culture DP cells that actually can induce a hair like fiber. However in the process a lot of gene expression is lost (the cultured cells dont resemble their original counter parts), so they're now trying to figure out how to increase that. And that's quite difficult at least. Therefore it's really impossible to say when it will happen. Might be tomorrow, might be another 35 years. However, one thing is for sure: if they figure it out tomorrow, you can expect 6-10 years clinical trials before it can even hit the market.

[Arashi]

But if you're specifically interested in the iPSC route -> yeah they need to figure out how to induce iPSC cells to become DP cells. There's not been a lot of research into this. Dr Xu indeed has been working somewhat on it but I think last time he said he was out of money. It seems like a viable route but also a long journey that's pretty much still has to even start.

[Hairismylife]

CB-03-01 is not for tomorrow or next year my friends sended them an email il copy the most relevant answers

The clinical trails for CB-03-01 phase 3 acne will start this year i assume right? yes
but will there be a clinical trail phase 3 for the same compound for alopecia or will there be an accelerated procedure (approval based on surrogate markers)? The alopecia trials is for the same compound but a different formulation and that requires a full clinical trial

also phase 3 will start in 2016 +-1year then we got fda review +- 1year so cb release date is 2018-2019 if anything goes normal !

Not important coz we can have off-market CB before that.