adipose-derived stem cell protein extract

[35YrsAfter]

So you're saying dr Coles prp is atleast maintaining hair for all of his prp patients?

As research continues to zero in on growth factors most beneficial to hair growth, we will surely be encouraging more men and women to have stand-alone PRP treatments. The various studies are like puzzle pieces. A pretty clear image is beginning to emerge in spite of all the missing pieces/unknowns. Just putting together what we learned from Cotsarelis and Valerie Horsley, it's clear that in MPB, there's a yet to be defined breakdown in a process that would normally lead to the production of platelet growth factors. Genetically predetermined hairs become "starved" and miniaturize.

Theory is one thing but we do "rubber meets the road" studies to evaluate what actually gets results. Other hair restoration physicians are doing the same. Dr. Cole is currently attending an annual scientific meeting where hair restoration doctors collaborate from all over the world.

According to articles I've read related to Valerie Horsley's study, bald scalp in men have a somewhat depleted adipose layer. Aside from PRP treatments, could the answer to MPB be as simple as restoring a more female-like adipose layer in the balding areas of scalp? I have noticed working here at Dr. Cole's that men using finasteride or dutasteride have a "spongier" scalp suggesting a better fatty layer than guys like me who only use Rogaine. Is adipose simply serving as a cell signalling medium? Cotsarelis confirmed that bald scalp has a sufficient supply of stem cells but a marked shortage of progenitor cells. Any way to stimulate the progenitor cell population? What does PGD2 actually put in motion that inhibits hair growth? Does it simply put normal hair cycles out of balance as Cotsarelis suggests? Lots of questions that need to be answered, but progress is being made.

Although a rodent model, the following image is from Valerie Horsley's Yale study:


35YrsAfter also posts as CITNews and works at Dr. Cole's office - forhair.com - Cole Hair Transplant, 1045 Powers Place, Alpharetta, Georgia 30009 - Phone 678-566-1011 - email 35YrsAfter at chuck@forhair.com
The contents of my posts are my opinions and not medical advice
Please feel free to call or email me with any questions. Ask for Chuck

[hgs1989]

Aside from PRP treatments, could the answer to MPB be as simple as restoring a more female-like adipose layer in the balding areas of scalp?

This question is bugging me the most. it is simple to answer yet no body is doing it. fat grafts are used in body augmentation, why nobody has tried it on a scalp. The paper I posted says: "transplantation of adipocyte progenitor cells intradermally into the back skin of shaved mice at the extended 3–4 week telogen stage of the hair follicle cycle that occurs around 7 weeks of age resulted in adipocyte graft formation and corresponding precocious hair growth. Anagen was induced in these mice injected with the enriched adipocyte progenitor cells"
also the fat layer in our scalps requires wnt/b-catenin signaling to differentiate. and we know the role of dkk1 in inhibiting wnt signaling source:http://www.ncbi.nlm.nih.gov/pubmed/24706781 . we could overcome this problem with fat injections and see what happens.

[clarence]

As research continues to zero in on growth factors most beneficial to hair growth, we will surely be encouraging more men and women to have stand-alone PRP treatments. The various studies are like puzzle pieces. A pretty clear image is beginning to emerge in spite of all the missing pieces/unknowns. Just putting together what we learned from Cotsarelis and Valerie Horsley, it's clear that in MPB, there's a yet to be defined breakdown in a process that would normally lead to the production of platelet growth factors. Genetically predetermined hairs become "starved" and miniaturize.

That's gonna take A LOT of research to justify the current price of PRP. We would be happier to see you encourage third parties to document consistent results, first off!!

[35YrsAfter]

This question is bugging me the most. it is simple to answer yet no body is doing it. fat grafts are used in body augmentation, why nobody has tried it on a scalp. The paper I posted says: "transplantation of adipocyte progenitor cells intradermally into the back skin of shaved mice at the extended 3–4 week telogen stage of the hair follicle cycle that occurs around 7 weeks of age resulted in adipocyte graft formation and corresponding precocious hair growth. Anagen was induced in these mice injected with the enriched adipocyte progenitor cells"
also the fat layer in our scalps requires wnt/b-catenin signaling to differentiate. and we know the role of dkk1 in inhibiting wnt signaling source:http://www.ncbi.nlm.nih.gov/pubmed/24706781 . we could overcome this problem with fat injections and see what happens.

Definitely worth a shot and I'm surprised that this hasn't been tried. I haven't heard of it being tried anyway. Women wanting a small increase in breast size and a more natural result are getting fat transfer breast augmentation. The listed possible complications are, infection, microcalcification, necrosis (death) of fat cells and the possibility that some of the transferred fat cells will migrate elsewhere. Definitely an acceptable risk level as long as some of the more serious complications are rare.

35YrsAfter also posts as CITNews and works at Dr. Cole's office - forhair.com - Cole Hair Transplant, 1045 Powers Place, Alpharetta, Georgia 30009 - Phone 678-566-1011 - email 35YrsAfter at chuck@forhair.com
The contents of my posts are my opinions and not medical advice
Please feel free to call or email me with any questions. Ask for Chuck

[35YrsAfter]

That's gonna take A LOT of research to justify the current price of PRP. We would be happier to see you encourage third parties to document consistent results, first off!!

I agree, it is expensive. The disposable cartridge for a top end blood spinner alone, cost upwards of $300. Although Dr. Cole has moved quite a few grafts into some needy areas of my scalp, he hasn't yet offered me free PRP . We recommend PRP at the time a patient has hair transplant surgery. If the hair mass index in non-transplanted areas show a significant spike 8 months to a year after it's administered, we will recommend ongoing PRP treatments. Our PRP results have improved over time as the formula has been improved. The addition of CRP could be a game changer.

35YrsAfter also posts as CITNews and works at Dr. Cole's office - forhair.com - Cole Hair Transplant, 1045 Powers Place, Alpharetta, Georgia 30009 - Phone 678-566-1011 - email 35YrsAfter at chuck@forhair.com
The contents of my posts are my opinions and not medical advice
Please feel free to call or email me with any questions. Ask for Chuck

[35YrsAfter]

Valerie Horsley’s Yale study cited evidence of the role adipose plays in cell communication that ultimately leads to the production of platelet derived growth factors (PDGF). Although obviously not a cure, low-level laser (light) therapy (LLLT) has been shown to improve hair growth. See study posted on the PubMed.gov website.

Recent studies suggest that LLLT's effectiveness relates to it improving cell signaling. This lends credibly to the comments related to adipose signalling in Valerie's Yale study.

35YrsAfter also posts as CITNews and works at Dr. Cole's office - forhair.com - Cole Hair Transplant, 1045 Powers Place, Alpharetta, Georgia 30009 - Phone 678-566-1011 - email 35YrsAfter at chuck@forhair.com
The contents of my posts are my opinions and not medical advice
Please feel free to call or email me with any questions. Ask for Chuck

[FearTheLoss]

does Dr. Cole offer LLLT?

[35YrsAfter]

does Dr. Cole offer LLLT?

No, not at this time. Dr. Cole does recognize the effectiveness of LLLT but the treatments clinics offer can be expensive for patients. For some men with hair loss, money is no object. Even in those cases, often times the best option in Dr. Cole's opinion is the Lasercap or Capillus. It's more convenient to use because you own it and don't have to take time out of your schedule to have treatments done at a doctor's office.

35YrsAfter also posts as CITNews and works at Dr. Cole's office - forhair.com - Cole Hair Transplant, 1045 Powers Place, Alpharetta, Georgia 30009 - Phone 678-566-1011 - email 35YrsAfter at chuck@forhair.com
The contents of my posts are my opinions and not medical advice
Please feel free to call or email me with any questions. Ask for Chuck

[nameless]

They could possibly be on to something, but it always bothers me to see a before photo taken with a flash and an after photo taken without a flash with the hair combed over the thin or balding area.

Screen capture from the video:
[ATTACH=CONFIG]35234[/ATTACH]

35YrsAfter also posts as CITNews and works at Dr. Cole's office - forhair.com - Cole Hair Transplant, 1045 Powers Place, Alpharetta, Georgia 30009 - Phone 678-566-1011 - email 35YrsAfter at chuck@forhair.com
The contents of my posts are my opinions and not medical advice
Please feel free to call or email me with any questions. Ask for Chuck

* I agree that it looks like they combed hair over a thinning area in the after picture, but not so sure I agree that we should be concerned with the flash issue.

* On the issue of the obvious comb-over, does it look like the same comb-over could have been achieved as effectively with the amount of hair in the before pic? I ask because if I got back say 40% of my lost hair that would be enough to make it possible for me to look like I have a lot of hair if I used illusory tactics the same as the guy in the before and after did. BUT with the amount of hair I presently have even illusory tactics would not make me look like I have a lot of hair. My point is that perhaps at the stage of the before pic the subject would not have been able to produce that same effect so he did not bother to try, but by the time of the after pic he gained enough thickness that he could produce that effect with illusory tactics so he did.

*If I got back enough hair that I could make myself look a lot better, but I didn't get back all of my hair, then I would take advantage of the fact that I got enough back to make myself look better and I would use illusory tactics to achieve the best possible look.


Would you please talk to Dr. Cole about adipose tissue implantation for treating hair loss? They are implanting fat all over people's bodies except nobody is trying it on the scalp. We need to try this. Yes there's a company doing small amounts of SVF, which comes from fat, but they are adding only a small amount of tissue. It would probably be better to implant larger amounts of fat tissue into balding scalp tissue as a test. Balding scalp has not lost just a little fat compared to scalp that is growing full thickness terminal hairs. Balding scalp is missing a significant amount of fat tissue. In order to find out if simply adding fat tissue would reverse hair loss you would want to add a significant amount of fat tissue. You would want to restore the fat layer to the same layer it was prior to hair loss. I understand that you wouldn't want to try this on a person because nobody knows it it will work, but you can get balding scalp tissue that's not attached to a person and try it on that tissue. We need this tested.

[Alias123]

http://www.korea.net/NewsFocus/Sci-Tech/view?articleId=122260

old news or is this new info?

[hellouser]

http://www.korea.net/NewsFocus/Sci-T...ticleId=122260

old news or is this new info?

Another study on mice.... sigh.

[nameless]

http://www.korea.net/NewsFocus/Sci-T...ticleId=122260

old news or is this new info?

I don't know if it's new or not, but it looks very interesting just the same. I think you should inform the doctors doing your hair treatments about this and ask them if they are adding platelet-derived growth factor-D (PDGF-D) to the culture.

I think it looks like platelet-derived growth factor-D (PDGF-D) improves the results.

[macbeth81]

http://www.korea.net/NewsFocus/Sci-T...ticleId=122260

old news or is this new info?

The mice were shaved and the Adipose-derived stem cells accelerated hair growth significantly. I don't see how this grows new hairs or rejuvenates miniaturized hairs. Seems more beneficial for women who want to grow their hair faster. Also the three to five years comment is classic.

[nameless]

The mice were shaved and the Adipose-derived stem cells accelerated hair growth significantly. I don't see how this grows new hairs or rejuvenates miniaturized hairs. Seems more beneficial for women who want to grow their hair faster. Also the three to five years comment is classic.

macbeth, this is one way you test whether or not a treatment will regrow miniaturized hairs. If it accelerates hair growth on mice then that means it's boosting the growing phase (anagen) and if it can boost anagen in miniaturized hairs on humans too that could result in miniaturized hairs getting longer and thicker. Do you understand?

What they accomplished is a VERY promising. I think we should be looking at adipose derived stem cells in combo with platelet-derived growth factor-D (PDGF-D.

[zeos]

I did email them at all of the email addresses you gave me.

any news on this?

Going for the Swiss Greek clinic next week

so, what happened ?