WCHR 2014 Presentations (Community-funded)

[Swooping]

https://www.youtube.com/watch?v=0klARAxOYiI

Culprit of AGA miniaturization indeed sir, good job. I totally share his hypothesis.

Androgens > AR > ROS/Oxidative stress > P53??? etc. > > >
> > .....

http://www.plosone.org/article/info%...l.pone.0031052 (many more on it though, also on hair follicle level)

[David7]

https://www.youtube.com/channel/UCJn...bGaoOWFS6kRxDQ

Thanks

[Thinning87]

Any thoughts on the other presentation?? I mean it seems like the Koreans are also trying wounding and growth factors (or taking away inhibitors)

I didn't really understand a lot

PS notice Cots asking questions

[nameless]

Any thoughts on the other presentation?? I mean it seems like the Koreans are also trying wounding and growth factors (or taking away inhibitors)

I didn't really understand a lot

PS notice Cots asking questions

Thinning if you mean the Koreans who are using adipose stem cell proteins and growth factors, I think that they are using growth factors but they aren't taking away inhibitors. And if you are talking about the scientists involved with adipose stem cells growth factors and proteins I don't think that they're using wounding.

Which Korean group are you referring to?

[David7]

Yes, can someone tell us whats happening ?I mean should we get our hopes up? I also noticed that theres a huge interest loss
in this thread.

[Thinning87]

Thinning if you mean the Koreans who are using adipose stem cell proteins and growth factors, I think that they are using growth factors but they aren't taking away inhibitors. And if you are talking about the scientists involved with adipose stem cells growth factors and proteins I don't think that they're using wounding.

Which Korean group are you referring to?

I don't know I couldn't really understand what the presenter was sayin g, but I'm referring to the new presentation that was posted. Not the one by the British guy but the one from the Korean guy. Seems early stage stuff though I mean they are out of a university lab

[hgs1989]

I remember desmond said cotseralis never mentioned anything about wounding, but watching the second presentation, it was all about wounding. anyhow, did desmond post his conversation with jahoda? the one he said he will post after emailing them about the content.

[35YrsAfter]

Creating hair follicles in vitro and then implanting them onto the scalp seems like a really backasswards way of doing things, but unfortunately that seems to be the aim of most research right now.

The ultimate goal in my view, is to somehow stimulate DHT resistant hair growth in bald areas in a way similar to how a newborn baby develops hair. During human development, the lanugo grows on fetuses as a normal part of gestation. It's usually shed and replaced by vellus hair at about 33 - 36 weeks of gestational age.

Another approach is surgical and one of treating the FUE donor area with a (future) refined regenerative agent so that extracted follicles moved to the balding areas grow back in their original extraction sites with 95 - 100% reliability.

ACell stimulates a degree of follicle regeneration. At this point in time, it benefits the patient by improving donor density post-op.

ACell is an extracellular matrix product made from pig's bladder. When ACell was cleared by the FDA for sale in the US to physicians, it was cleared as a medical device. In other words, it was viewed as a "scaffolding" that maintains cell position kind of like how 2x4 studs hold the siding and sheetrock in place. Extracellular matrix exists between all soft tissue cells in the body. It has later been verified that extracellular matrix serves as a cell communication medium in addition to being a sort of scaffolding. Dr. Cole developed a minimal depth FUE extraction method where the follicle is scored about half way down. The soft tissue below allows the scored follicles to be eased out. This leaves stem cells behind. The ACell powder mixed with hyaluronic acid creates a gel that when placed in the extraction sites creates a scaffolding as well as restores a degree of cell communication. Because of the improved cell communication, the body has a better idea what used to be at the extraction site and the ACell gel promotes tissue remodeling. When the body doesn't know what used to be at an injury site, the body calls on its generic "filler" known as scar tissue.

Dr. Cole is currently moving tissue remodeling forward in his practice with a new medical product called AmnioFix.

35YrsAfter also posts as CITNews and works at Dr. Cole's office
forhair.com
Cole Hair Transplant
1070 Powers Place
Alpharetta, Georgia 30009
Phone 678-566-1011
email 35YrsAfter at chuck@forhair.com
The contents of my posts are my opinions and not medical advice
Please feel free to call or email me with any questions. Ask for Chuck

[Artista]

Chuck hi my friend-that was a great 'lay-mens' way of explaining the use of Acell in this case! Acell is still progressing in all types of usages.

[clandestine]

I mean should we get our hopes up?

It would be entirey foolish to do so.

Your call, though.

[joachim]

The ultimate goal in my view, is to somehow stimulate DHT resistant hair growth in bald areas in a way similar to how a newborn baby develops hair. During human development, the lanugo grows on fetuses as a normal part of gestation. It's usually shed and replaced by vellus hair at about 33 - 36 weeks of gestational age.

Another approach is surgical and one of treating the FUE donor area with a (future) refined regenerative agent so that extracted follicles moved to the balding areas grow back in their original extraction sites with 95 - 100% reliability.

ACell stimulates a degree of follicle regeneration. At this point in time, it benefits the patient by improving donor density post-op.

ACell is an extracellular matrix product made from pig's bladder. When ACell was cleared by the FDA for sale in the US to physicians, it was cleared as a medical device. In other words, it was viewed as a "scaffolding" that maintains cell position kind of like how 2x4 studs hold the siding and sheetrock in place. Extracellular matrix exists between all soft tissue cells in the body. It has later been verified that extracellular matrix serves as a cell communication medium in addition to being a sort of scaffolding. Dr. Cole developed a minimal depth FUE extraction method where the follicle is scored about half way down. The soft tissue below allows the scored follicles to be eased out. This leaves stem cells behind. The ACell powder mixed with hyaluronic acid creates a gel that when placed in the extraction sites creates a scaffolding as well as restores a degree of cell communication. Because of the improved cell communication, the body has a better idea what used to be at the extraction site and the ACell gel promotes tissue remodeling. When the body doesn't know what used to be at an injury site, the body calls on its generic "filler" known as scar tissue.

Dr. Cole is currently moving tissue remodeling forward in his practice with a new medical product called AmnioFix.

35YrsAfter also posts as CITNews and works at Dr. Cole's office
forhair.com
Cole Hair Transplant
1070 Powers Place
Alpharetta, Georgia 30009
Phone 678-566-1011
email 35YrsAfter at chuck@forhair.com
The contents of my posts are my opinions and not medical advice
Please feel free to call or email me with any questions. Ask for Chuck

did dr. Cole see some donor regeneration so far? if yes, was it documented? how many percent are realistic today? 3 to 5 % maybe? and how does that affect the recipient site? still the same survival rate with such extraction technique?

[Thinning87]

Chuck hi my friend-that was a great 'lay-mens' way of explaining the use of Acell in this case! Acell is still progressing in all types of usages.

just seems like a commercial for his employer to me... every comment in every thread is an opportunity to talk about Dr. Cole

[hellouser]

just seems like a commercial for his employer to me... every comment in every thread is an opportunity to talk about Dr. Cole

It's paid advertising for Dr. Cole. One of Spencer Kobren's methods of income.

[joachim]

by the way where is desmond all the time? there's still so much to discuss and clarify. and from where the hell do we find out how far the chinese are with the DP culturing? did they achieve 100% gene expression or not? if it turns out that they are ahead of jahoda/gardner and also taiwan in terms of DP gene expression, this changes things dramatically.
currently the 100% goal is what jahoda/gardner are trying to achieve. this will be their main focus for the next 1,2,3 years or even longer. but if there is really someone out there in the world who cracked the code already, then let's not waste some more years on that.

[nameless]

I remember desmond said cotseralis never mentioned anything about wounding, but watching the second presentation, it was all about wounding. anyhow, did desmond post his conversation with jahoda? the one he said he will post after emailing them about the content.

I'm at work for another 6 hours so I can't check out that 2nd presentation. Are you talking about a 2nd presentation by Cotseralis? Does it involve wounding? What does it say about wounding?