WCHR 2014 Presentations (Community-funded)

[agardner]

Hey Aaron,

First of all thanks for joining our forum, you are of great help !

Secondly, will the treatment/cure you are working on (or any other teams) benefit those who suffer from Diffuse Unpatterned Alopecia? So will it restore a full head of hair to even those who have no terminal hairs?

I'm not sure. The majority of studies use epithelial cells that are very receptive to follicle induction i.e. mouse or human neonatal epithelial cells. We are attempting to use adult human only cells, but this is "healthy" tissue. As far as I know there are no groups using alopecia scalp tissue to test for inductivity. Speculating, I would assume if an inductive enough construct was created that the initial follicle would form. However, as this isn't treating the underlying causes of the various alopecias I would assume the follicle would then degrade as the previously, perhaps even at a faster rate due to the loss of fatty tissue in the scalp.

Would this not be bound to the same strenuous FDA clinical trials that last another 8+ years? As you know, many of us have been desperate for years and decades to move on with our lives, so we're looking at the fastest possible treatment. Is there some other country whose health ministry is less restricting on use of stem cell therapy in which we could see a treatment that actually holds up to the typical 'within 5 years' claim?

Thanks and welcome to the forum!!

I'm not American or a clinical trials expert so I'm not sure what would have to occur. In the UK if the clinical trial is robust enough then things can pass quite quickly through the MHRA (our equivalent of the FDA). But as I say I'm no clinical trials expert so I can't give you a time frame for that. I was referring to the initial experiment demonstrating the technique appearing without warning.

Wow, thanks for your elaborate answer Aaron !! Very well laid out, thanks, that clears up my questions and I understand what you guys are doing now. Will come back later though with some other questions, hope you don't mind

Thanks again for coming to this forum and explaining all this to us, you're our biggest hope for the future, good luck with your experiments !!

No worries, happy to explain what I'm up to.

How is hair growth direction controlled?

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The follicle structures orientate towards the epidermis and do not form cysts. However in the study by Dr Higgins, and my continuation of her work, we are not looking at patterning or angle of egress etc. That's something that will come when we're achieving reliable follicle induction.

[Arashi]

Thanks Dr Gardner !

Some time ago a forum member asked dr Xu some question, he replied:

One recent study (Higgins et al., 2013) showed that DP cells can maintain their follicular genetic capacity if they are cultured in 3D. If you read the paper carefully, they used passage 2-3 cells to make a DP cell aggregate in the culture. Since each DP aggregate contains many cells, it means that this procedure can maintain DP cell folliculogenecity, but not necessarily make more DP cell aggregates. Therefore, the authors may or may not be able to make more DP cell aggregates (and more hair follicles) than the original hair follicles that they have taken out from the patients.

I didnt really understand what he was saying here. Why wouldnt you be able to make more cell aggregates if you can culture the cells and keep their follicle genetic capacity ? Or do you think he's just merely implying that not all cells can be used because of low efficiency ?

[hellouser]

I'm not American or a clinical trials expert so I'm not sure what would have to occur. In the UK if the clinical trial is robust enough then things can pass quite quickly through the MHRA (our equivalent of the FDA). But as I say I'm no clinical trials expert so I can't give you a time frame for that. I was referring to the initial experiment demonstrating the technique appearing without warning.

Sounds great! Thanks!

Would you be able to provide a 'dumbed down' explanation of your method of creating functioning follicles for humans? Perhaps in 5 short steps? I'm a graphic artist and will be creating an infographic to inform everyone of past successes, current projects, future treatments, barriers, social prejudice and discrimination against men with baldness and psychological effects on both men and women with hair loss. There have been talks about a raising funds for future treatments to expedite progress with regards to costs... naturally, Dr. Jahoda's team has been on our radar for some time now thanks to Desmond84. If all goes well I and others have been more than willing with a grassroots movement. The infographic would be a good starting piece to a very large project.

[joachim]

I created a new thread here, for questions & answers with Dr. Aaron Gardner.
So we don't have to go through 50+ pages.

here:

http://www.baldtruthtalk.com/showthread.php?t=16284

[Arashi]

Ok I've copied the Q&A's from this thread into your new one. If you have a question, please ask it there but please keep it on topic there people !!

[nameless]

Chill out dude, I wonder if you really use that tone in the real world

What are your options? Which country? Which agency?

You keep talking trash about the FDA and a magical country and agency out there that is better, but where are them? what are the options? have you talked about them to people who are knowledgable about clinical trials? Why do they still keep on doing the trials with the FDA?

This isn't about a "random number of years", where are you getting that info? As far as I know the FDA doesn't place a hard number concerning the length of a trial

Anyway dude, you still can contact me if you want, if you need to vent something

You tell people to "Chill out" and then you talk about their tone. Perhaps your tone is the tone that needs to chill.

There's not one thing wrong with what Hellouser's saying. I agree with him 100% about this issue.

[hellouser]

A lot of hair systems already look amazing

But they still have the stigma, they can looks as natural as your original hair, but you are screwed the moment someone finds out you are wearing a wig

We need bald stars to embrace them to remove the stigma

We have one, John Travolta, a former A-lister and people still feel obligated to completely destroy a persons integrity over their hair loss. Even Jon Cryer is shameless about his hair loss and concealers.

Society isn't going to change. Forget it.

[joachim]

We have one, John Travolta, a former A-lister and people still feel obligated to completely destroy a persons integrity over their hair loss. Even Jon Cryer is shameless about his hair loss and concealers.

Society isn't going to change. Forget it.

John Travolta is visibly suffering under his baldness. Further, reporters are questioning him always about his hair which is really nasty.
If we ever start a crowdfunding campain, we have to find a way to reach out to the celebs and give them a chance to talk to us anonymously. I'm sure John Travolta would carry the crowdfunding himself. 20 millions is nothing for him. If we have a serious chance of accelerating the cure by years with this money, he wouldn't have to think twice about it.

Money is really not a serious problem in this game.

[hellouser]

John Travolta is visibly suffering under his baldness. Further, reporters are questioning him always about his hair which is really nasty.
If we ever start a crowdfunding campain, we have to find a way to reach out to the celebs and give them a chance to talk to us anonymously. I'm sure John Travolta would carry the crowdfunding himself. 20 millions is nothing for him. If we have a serious chance of accelerating the cure by years with this money, he wouldn't have to think twice about it.

Money is really not a serious problem in this game.

There are many, MANY celebrities that would benefit greatly from having their hair back. If they helped us anonymously we'd have the funds in a very, VERY short time. We just need to make it looks as legitimate and promising as possible. They're NOT going to throw money at chances. They're going to want guarantees, not 'hopes'. But thats another discussion.

[Artha]

What about Juda Law!

[BoSox]

New article:

http://www.newsmaxhealth.com/Health-News/baldness-cure-advance-thinning/2014/05/16/id/571814/#CommentSection

Video near bottom.

[hellouser]

New article:

http://www.newsmaxhealth.com/Health-News/baldness-cure-advance-thinning/2014/05/16/id/571814/#CommentSection

Video near bottom.

Meh. 11 minute video and she spent most of the time talking about women's hair loss. I really don't see how the numbers in women with hair loss are as high as they say they are.

[Artha]

I really don't see how the numbers in women with hair loss are as high as they say they are.

The number of women with hair loss is about the same as men but they lose it slower!

[mmmcoffee]

I gotta say, there's a cashier at the cafeteria at my work, she has lost maybe 80% of her hair, nearly slick bald on top. She don't seem to care....makes all of us on here look like a bunch of p*****s honestly.

Though it's more common in men to have that degree of loss, it's equally as important for women to get a cure...

[nameless]

The number of women with hair loss is about the same as men but they lose it slower!

There are about 20 million women in America dealing with hair loss and 35 million men. Also, women only lose their hair slower they also don't go bald in the huge numbers that men do.