WCHR 2014 Presentations (Community-funded)

[JZA70]

then it's a quasi-cure in my opinion. cots should tell us more about it.

Well its either a treatment or a cure and we don't need any more treatments.

[nameless]

Stem Cell Hair Regrowth Treatment Breakthrough So…: http://youtu.be/i7_fvcigbeA

so this is the video which probably everyone of us have seen already.
in my opinion the new white hair is pretty dense. if cots can do that on my scalp, i'm in!
they are talking about missing pigments in mice, thus the white color. shouldn't be the case with humans. but even if the wounding would produce white colored hair only, i wouldn't mind. i just would dye it. no problem at all.

so that white dense mouse hair was years ago.
if the finished follica trials show similar results in human scalp, then it's a quasi-cure in my opinion. cots should tell us more about it.

If he could do that in humans then why is having trouble getting $2 million lousy dollars? It's nothing. Like you said, even if it was white all you would have to do is dye it. It doesn't make sense that he can't get $2 million if he can match that efficacy in humans.

[NeedHairASAP]

I officially don't trust cots.

There are professional investors all over the world. It isn't that hard to round up a 2M series-A private investment round-- if he's that close. He obviously isn't or he would have the money.

[Arashi]

Good morning Desmond, how is everything going ? In 3 hours Team Jahoda talks, in my opinion the most important presentation of the conference, exciting ! I'm really hoping you can get to chat with them !!

Good luck brother !

[hellouser]

Holy crap, our initiative with Desmond got noticed on the web, look!

[Promotional link removed]

What’s more, several members of other online hair restoration discussion forums started a crowd-funding initiative and raised enough capital to send a member to report on the conference. The member has a background in science and agreed to record and report on the conference and interview several prominent researchers.

[Mike K]

Holy crap, our initiative with Desmond got noticed on the web, look!

Hell yea!

[Desmond84]

Hey guys.

Today I have some more great news for you. I met up with a Singapore team who compared dermal papillae cells from balding to permanent zone of the scalp and found that transcriptosome differences may be responsible for androgen sensitivity of DP cells in the balding zone!

So I asked what's their solution to this problem? Would you have to use a retrovirus to correct these genetic differences (ie. Gene therapy)?

They pointed out that gene therapy is still 1-2 decades away and its safety is still very controversial. They hypothesised a different approach! Once they perform the genomics and proteomics studies they will hone in on the exact proteins needed to be blocked and simply by inhibiting protein synthesis they will stop androgen sensitivity in the balding scalp!

So in other words a permanent halt of hair miniaturisation! Don't forget that finasteride works in a similar manner per say by blocking a protein called 5 alpha reductase which converts testosterone to DHT. Their method will target a different protein which is responsible for telling DP cells to express androgen receptors which is detrimental to their health.

Timeline wise, they're hoping the proteomics should be conclouded in the next 2 years. Fascinating stuff.

She is emailing me a copy of her poster and I'll share it as soon as I get it

[nameless]

Holy crap, our initiative with Desmond got noticed on the web, look!

And this is the sort of thing that could help in gaining larger crowd-funding and that could result in a $2 million investment into Cotseralis but why is Cotseralis having trouble securing a lousy $2 million if he can produce significantly better results than minoxidil/propecia.

Hellouser isn't that hard to understand? $2 million is a drop in the bucket and investors are used to putting up that kind of money for potential baldness breakthroughs. This is very hard to understand.

[nameless]

Hey guys.

Today I have some more great news for you. I met up with a Singapore team who compared dermal papillae cells from balding to permanent zone of the scalp and found that transcriptosome differences may be responsible for androgen sensitivity of DP cells in the balding zone!

So I asked what's their solution to this problem? Would you have to use a retrovirus to correct these genetic differences (ie. Gene therapy)?

They pointed out that gene therapy is still 1-2 decades away and its safety is still very controversial. They hypothesised a different approach! Once they perform the genomics and proteomics studies they will hone in on the exact proteins needed to be blocked and simply by inhibiting protein synthesis they will stop androgen sensitivity in the balding scalp!

So in other words a permanent halt of hair miniaturisation! Don't forget that finasteride works in a similar manner per say by blocking a protein called 5 alpha reductase which converts testosterone to DHT. Their method will target a different protein which is responsible for telling DP cells to express androgen receptors which is detrimental to their health.

Timeline wise, they're hoping the proteomics should be conclouded in the next 2 years. Fascinating stuff.

She is emailing me a copy of her poster and I'll share it as soon as I get it

Desmond are you getting technical information how to culture DP/epithelial cells mass pass without loss of hair inductivity/trichogenicity? That's what we need.

[fuzzyballs]

Hey guys.

Today I have some more great news for you. I met up with a Singapore team who compared dermal papillae cells from balding to permanent zone of the scalp and found that transcriptosome differences may be responsible for androgen sensitivity of DP cells in the balding zone!

So I asked what's their solution to this problem? Would you have to use a retrovirus to correct these genetic differences (ie. Gene therapy)?

They pointed out that gene therapy is still 1-2 decades away and its safety is still very controversial. They hypothesised a different approach! Once they perform the genomics and proteomics studies they will hone in on the exact proteins needed to be blocked and simply by inhibiting protein synthesis they will stop androgen sensitivity in the balding scalp!

So in other words a permanent halt of hair miniaturisation! Don't forget that finasteride works in a similar manner per say by blocking a protein called 5 alpha reductase which converts testosterone to DHT. Their method will target a different protein which is responsible for telling DP cells to express androgen receptors which is detrimental to their health.

Timeline wise, they're hoping the proteomics should be conclouded in the next 2 years. Fascinating stuff.

She is emailing me a copy of her poster and I'll share it as soon as I get it

Thanks Desmond! Love your work brother!!

So are you saying that something could be on the market in 2 years? Do you know if it will restore as well as halt hair loss?

[hellouser]

Hey guys.

Today I have some more great news for you. I met up with a Singapore team who compared dermal papillae cells from balding to permanent zone of the scalp and found that transcriptosome differences may be responsible for androgen sensitivity of DP cells in the balding zone!

So I asked what's their solution to this problem? Would you have to use a retrovirus to correct these genetic differences (ie. Gene therapy)?

They pointed out that gene therapy is still 1-2 decades away and its safety is still very controversial. They hypothesised a different approach! Once they perform the genomics and proteomics studies they will hone in on the exact proteins needed to be blocked and simply by inhibiting protein synthesis they will stop androgen sensitivity in the balding scalp!

So in other words a permanent halt of hair miniaturisation! Don't forget that finasteride works in a similar manner per say by blocking a protein called 5 alpha reductase which converts testosterone to DHT. Their method will target a different protein which is responsible for telling DP cells to express androgen receptors which is detrimental to their health.

Timeline wise, they're hoping the proteomics should be conclouded in the next 2 years. Fascinating stuff.

She is emailing me a copy of her poster and I'll share it as soon as I get it

Great work Desmond! That's definitely promising, finally something that doesn't alter our masculinity!

Two questions;

1) Did you get my email with Dr. Lindner?
2) Did you ask Dr. Cotsarelis if Follica's method can be repeated for increased density?

Thanks!!

[fuzzyballs]

@hell - are you serious that all we need is $2M - 20M to fund Cotsarelis and Follica?

If answer = yes, than will the real hellouser please stand up please standup... because you're clearly an alien, if it was only $2M then hairloss would be solved and Cotsarelis would already be rich.

I suspect Cotsarelis just wants to be funded to the tune of $2M for the next couple of years.

If it were true he's have $100M in the bank right now. I will not spend a cent on Cotsarelis via crowdfunding. Its a bad use of money.

We'd be MUCH better of crowdfunding Histogen.

[nameless]

Thanks Desmond! Love your work brother!!

So are you saying that something could be on the market in 2 years? Do you know if it will restore as well as halt hair loss?

No.

He's saying that in 2 years the research team will know which proteins are needed to be blocked in order to prevent androgen receptors from being formed.

After that then they will have to create a blocker to that protein.

After that they will have to test it in animals and then humans.

It could be on the market in about 12 years.

[joachim]

hi desmond,

if you find the time, i would appreciate it if you can listen to the speech P146, starting 9.40AM.
sounds like a new device for hair transplants... with 3 needles or so.
i'm curious what they are talking about. maybe it enables better HT yields, or reduce trauma and redness. maybe it enables more density for HTs, because needle thickness is key here. if lauster comes up with hair cloning someday, HT implanting techniques definitely should be improved to enable great density. maybe this device goes into that direction.

if you find the time to record it, would be cool.

thanks

[Desmond84]

Guys this is a very technically intensive congress. A lot of information is being presented. I will let you sieve through the data at your own pace. So don't worry the technical information is being presented.

As for the 2 year timeline, that's preclinical work. You need to add at least 6 more years for clinical trials unless the compound already existed on the market, which may be!