wtf is going with HISTOGEN phase 2b?

[greatjob!]

We continue with ACell studies in order to improve follicle regeneration from its current average of about 50%. At this current stage, ACell preserves donor hair.

We didn't develop or create extracellular matrix products (ACell). Regeneration is not solely Dr. Cole's claim. ACell is approved by the FDA as a regenerative product. Well-known doctors for example, Dr. Cooley, Dr. Mwamba, and Dr. Wesley acknowledge ACell's regenerative properties. If you have a problem with ACell's claims, you should contact the Food and Drug Administration.

It's like a race car driver making a statement that a motor oil product reduces friction. If people want proof, go the manufacturer of the oil additive, not the race car driver. We publish studies to improve treatments for patients.

I respect Dr. Cole for his willingness to research and adopt new techniques and I do believe if Histogen is successful he will be one of the first in line to offer it. However to be fair ACell is not aproved for and has never claimed that it can regenerate hair follicles. It's used for wound healing and Dr. Cole and other doctors are testing it's ability to regenerate follicles.

Also I have heard Dr. Cole and you claim on here many times that you are getting 50+% regeneration rates, but I have yet to see any evidence to back those claims up. Do you guys have concrete evidence where that figure was derived from, or is this just an estimate from anecdotal evidence? 50% regeneration is a pretty remarkable claim and as such should require remarkable evidence to back it up, otherwise you guys just sound like Dr. Nigam.

[Tenma]

otherwise you guys just sound like Dr. Nigam.

Couldn't agree more

[Kiwi]

I asked this question and didn't receive a straight answer. I'm still waiting for a proper answer... would like to see NW6 -> NW1

We've dragged Nigram over the coals to show us proof. Time Cole showed us proof now...

[hellouser]

We've dragged Nigram over the coals to show us proof. Time Cole showed us proof now...

+1

Arashi's investigative skills would be of great help. Perhaps a 50 graft test would be beneficial?

[HairBane]

lol oh man, 35yearsafter you've really dropped cole in it. terrible publicity.

[FearTheLoss]

lol oh man, 35yearsafter you've really dropped cole in it. terrible publicity.

Not terrible publicity if he can back up his claims.

[greatjob!]

lol oh man, 35yearsafter you've really dropped cole in it. terrible publicity.

Not terrible publicity if he can back up his claims.

Cole literally says the same thing almost daily on here. The sad thing is that they make claims of achieving 50+% donor regeneration on a thread that they are posting prolifically on, and then someone asks for evidence to validate their claims and then they magically disappear, so I would be very surprised if either of them posted on this thread again.

[35YrsAfter]

Cole literally says the same thing almost daily on here. The sad thing is that they make claims of achieving 50+% donor regeneration on a thread that they are posting prolifically on, and then someone asks for evidence to validate their claims and then they magically disappear, so I would be very surprised if either of them posted on this thread again.

A sound advice I hear repeatedly in the hair loss forums is. "Do your research".

Here are some useful search terms I have used in Google:
regenerative medicine
hair follicle regeneration
extracellular matrix
ACell regenerative

Regenerative medicine is a reality. Why not hair follicles? Dr. Cole is not the only doctor who affirms the regenerative properties of ACell. Dr. Wesley, for instance placed a still image of follicle regeneration in his Pilofocus video presentation.

Dr. Cole began using ACell because it reduces hypopigmentation in the donor sites. He noticed that when his patients came back for a second surgery the donor areas looked fuller than they should have been. It was at that point he began counting and documenting hair growing from his patient's extraction sites. At Dr. Cole's office, we offer a shaven and non-shaven procedure. When patients return for their next shaven surgery, 8 months to 12 months post-op, Dr. Cole will count hairs growing from extraction sites.

Documentation of our internal observations are kept in an Excel spreadsheet. 10% to 70% follicle regeneration with approximately 50% being the average is calculated from those hair counts.

Our internal studies prove to us that the cost we incur buying ACell's expensive products is worth it for our patients.

I have already posted photos showing hair growing from extraction sites. I will speak with Dr. Cole on Monday about putting a website together documenting our ACell studies. With a Website, I can just post a link.

Please examine other accounts of regenerative successes. Make up your own mind. If it's not for you, don't use it. Dr. Cole is not the only source of information about ACell's effectiveness. Not sure who assigned Dr. Cole the job of proving ACell's effectiveness. Many other doctors are having success with extracellular matrix products. Some doctors are having limited success because they use full-depth extractions removing all of the stem cells. Follicle regeneration isn't like were claiming life on Mars, time travel or teleportation. Hair seems to grow easily all over the body and in places its unwanted. It's frustrating that it sometimes resists growth where we want it. I believe that extracellular matrix will play an important role in the future of hair restoration.

Any of you guys live in the Atlanta area? If so, contact me.

35YrsAfter also posts as CITNews and works at Dr. Cole's office
forhair.com
Cole Hair Transplant
1045 Powers Place
Alpharetta, Georgia 30009
Phone 678-566-1011
email 35YrsAfter at chuck@forhair.com
I am not a doctor and the content of my posts are my opinions, not medical advice.
Please feel free to call or email me with any questions. Ask for Chuck

[yeahyeahyeah]

A sound advice I hear repeatedly in the hair loss forums is. "Do your research".

Here are some useful search terms I have used in Google:
regenerative medicine
hair follicle regeneration
extracellular matrix
ACell regenerative

Regenerative medicine is a reality. Why not hair follicles? Dr. Cole is not the only doctor who affirms the regenerative properties of ACell. Dr. Wesley, for instance placed a still image of follicle regeneration in his Pilofocus video presentation.

Dr. Cole began using ACell because it reduces hypopigmentation in the donor sites. He noticed that when his patients came back for a second surgery the donor areas looked fuller than they should have been. It was at that point he began counting and documenting hair growing from his patient's extraction sites. At Dr. Cole's office, we offer a shaven and non-shaven procedure. When patients return for their next shaven surgery, 8 months to 12 months post-op, Dr. Cole will count hairs growing from extraction sites.

Documentation of our internal observations are kept in an Excel spreadsheet. 10% to 70% follicle regeneration with approximately 50% being the average is calculated from those hair counts.

Our internal studies prove to us that the cost we incur buying ACell's expensive products is worth it for our patients.

I have already posted photos showing hair growing from extraction sites. I will speak with Dr. Cole on Monday about putting a website together documenting our ACell studies. With a Website, I can just post a link.

Please examine other accounts of regenerative successes. Make up your own mind. If it's not for you, don't use it. Dr. Cole is not the only source of information about ACell's effectiveness. Not sure who assigned Dr. Cole the job of proving ACell's effectiveness. Many other doctors are having success with extracellular matrix products. Some doctors are having limited success because they use full-depth extractions removing all of the stem cells. Follicle regeneration isn't like were claiming life on Mars, time travel or teleportation. Hair seems to grow easily all over the body and in places its unwanted. It's frustrating that it sometimes resists growth where we want it. I believe that extracellular matrix will play an important role in the future of hair restoration.

Any of you guys live in the Atlanta area? If so, contact me.

35YrsAfter also posts as CITNews and works at Dr. Cole's office
forhair.com
Cole Hair Transplant
1045 Powers Place
Alpharetta, Georgia 30009
Phone 678-566-1011
email 35YrsAfter at chuck@forhair.com
I am not a doctor and the content of my posts are my opinions, not medical advice.
Please feel free to call or email me with any questions. Ask for Chuck

If Dr Cole is getting 50% regeneration, does that mean he can perform more aggressive hair transplants.

I am very keen in getting a HT to restore my hairline to a NW1 from 2. But I do not want to be in a situation where I run out of donor hair.

[greatjob!]

A sound advice I hear repeatedly in the hair loss forums is. "Do your research".

Here are some useful search terms I have used in Google:
regenerative medicine
hair follicle regeneration
extracellular matrix
ACell regenerative

Regenerative medicine is a reality. Why not hair follicles? Dr. Cole is not the only doctor who affirms the regenerative properties of ACell. Dr. Wesley, for instance placed a still image of follicle regeneration in his Pilofocus video presentation.

Dr. Cole began using ACell because it reduces hypopigmentation in the donor sites. He noticed that when his patients came back for a second surgery the donor areas looked fuller than they should have been. It was at that point he began counting and documenting hair growing from his patient's extraction sites. At Dr. Cole's office, we offer a shaven and non-shaven procedure. When patients return for their next shaven surgery, 8 months to 12 months post-op, Dr. Cole will count hairs growing from extraction sites.

Documentation of our internal observations are kept in an Excel spreadsheet. 10% to 70% follicle regeneration with approximately 50% being the average is calculated from those hair counts.

Our internal studies prove to us that the cost we incur buying ACell's expensive products is worth it for our patients.

I have already posted photos showing hair growing from extraction sites. I will speak with Dr. Cole on Monday about putting a website together documenting our ACell studies. With a Website, I can just post a link.

Please examine other accounts of regenerative successes. Make up your own mind. If it's not for you, don't use it. Dr. Cole is not the only source of information about ACell's effectiveness. Not sure who assigned Dr. Cole the job of proving ACell's effectiveness. Many other doctors are having success with extracellular matrix products. Some doctors are having limited success because they use full-depth extractions removing all of the stem cells. Follicle regeneration isn't like were claiming life on Mars, time travel or teleportation. Hair seems to grow easily all over the body and in places its unwanted. It's frustrating that it sometimes resists growth where we want it. I believe that extracellular matrix will play an important role in the future of hair restoration.

Any of you guys live in the Atlanta area? If so, contact me.

Thanks for the reply. I apologize for my last post in this thread, it was a little hostile. Its the holidays, it was late and I had been drinking, lol.

I understand the current state of regenerative medicine, I study and work in the biotech field. I'm just saying that to make the statement that ACell is FDA approved and then talk about regenerating follicles in the same sentence is quite misleading since not even ACell or the FDA mention anything about hair follicle regeneration. I'm sure you can understand everyone's skepticism, there are many doctors claiming regeneration, but none showing clear evidence other than their words and a few select pictures.

I'm sure Dr. Cole is seeing regeneration, its just hard for us to believe the rate of regeneration when its not presented in a clear quantifiable manner. You might want to suggest to Dr. Cole that he thinks about doing a few 50 graft test cases, I'm sure you could even get volunteers from the forums, if I lived in the area I would do it for sure.

I'm not trying to disprove anything like we were trying to do with Nigam, he had no reputation to stand on and was a liar, obviously Dr. Cole shouldn't even be mentioned in the same sentence, but it would be nice to get an idea of where regeneration really sits with Dr. Cole and ACell. If it ends up being 20% on the test cases great, if it ends up being 80% great, I wouldn't consider either of you liars since regeneration rates seem to be so variable at this point. Any real evidence of regeneration that can be shown is only going to be good for the industry and help to push the field further.

[FearTheLoss]

Thanks for the reply. I apologize for my last post in this thread, it was a little hostile. Its the holidays, it was late and I had been drinking, lol.

I understand the current state of regenerative medicine, I study and work in the biotech field. I'm just saying that to make the statement that ACell is FDA approved and then talk about regenerating follicles in the same sentence is quite misleading since not even ACell or the FDA mention anything about hair follicle regeneration. I'm sure you can understand everyone's skepticism, there are many doctors claiming regeneration, but none showing clear evidence other than their words and a few select pictures.

I'm sure Dr. Cole is seeing regeneration, its just hard for us to believe the rate of regeneration when its not presented in a clear quantifiable manner. You might want to suggest to Dr. Cole that he thinks about doing a few 50 graft test cases, I'm sure you could even get volunteers from the forums, if I lived in the area I would do it for sure.

I'm not trying to disprove anything like we were trying to do with Nigam, he had no reputation to stand on and was a liar, obviously Dr. Cole shouldn't even be mentioned in the same sentence, but it would be nice to get an idea of where regeneration really sits with Dr. Cole and ACell. If it ends up being 20% on the test cases great, if it ends up being 80% great, I wouldn't consider either of you liars since regeneration rates seem to be so variable at this point. Any real evidence of regeneration that can be shown is only going to be good for the industry and help to push the field further.

I agree with this, we should put together a website and do a few test cases.

[Thinning87]

If anyone cares to talk about histogen here, rather than some phony hair transplant publicity, they are going to present at the stem cell meeting in San Diego this Wednesday at 2:30 pm.

I don't know if they will say something we're interested in besides showing the usual statistics from phase 1/2A.

[I am ready]

I don't know if they will say something we're interested in besides showing the usual statistics from phase 1/2A.

Do you mean their fake photos?

[Thinning87]

Do you mean their fake photos?

We have debated this in full. Choose which side you want, I doubt anyone here cares.

What's important is how do we follow the event, if possible?

[I am ready]

What's important is how do we follow the event, if possible?

You are right. And you should know that I will keep my fingers crossed for them, but I think they are on the same path as Aderans. :-(