Reason why there is still no cure in 2013 and the solution

[hellouser]

Why did you cut the dose?

Drop in libido, though I've noticed its down again :/

[25 going on 65]

Only side effect I've had from RU is reduced libido. Thats it.

Results came in nicely earlier this year a couple months after I started RU at 100mg/1ml. I'm on it now again but at 50mg/1ml every other day (on off days I use CB).

Why did you cut the dose?

[hellouser]

I've been meaning to ask you about your use of RU. Have you had side effects from it? What makes RU less dangerous for libido and such compared to Finasteride? Have you seen much in terms of results?

And 2 years is nothing in the grand scheme of things. When my dad was balding, he just.. had to go bald, there was nothing. We have potential cures just out of arm's reach.

Only side effect I've had from RU is reduced libido. Thats it.

Results came in nicely earlier this year a couple months after I started RU at 100mg/1ml. I'm on it now again but at 50mg/1ml every other day (on off days I use CB).

[hellouser]

Desmond, did you know Dr. Nigam said he's willing to sponsor you to go to India and scrutinize him? From HS:

"I can also sponsor(with return air ticket and hotel) roger,freddie or desmond or spencer,or anybody hair loss community decides, who may be considered neutral scientifically knowledgible to thoroughly scrutinized me, my team, my clinic, my lab and my association once and for all..."

I got money to throw down on such an endeavor. I trust Desmond more than any other member here (no offense guys!)

[HairBane]

There are TWO possible ways that Tsuji will try to tackle the 'Density' issue. They'll be testing the theories in their preclinical trials to see which one is more successful.

If Tsuji is able to implant 'hair germs' into scalp and they can mature within the scalp to an actual hair follicle then there's nothing to worry about! They have learnt in their previous study that implanting 28 germs in a 1 cm2 area would give you on average 120-150 hairs, which is pretty much your juvenile hair density!

If they couldn't do that and have to place the hair germs in some kind of assay to grow them to maturity, they then have to perform a FUT to transplant these hair follicles. Under such circumstances, the hair density will depend on how advance our hair transplant methods are. This will not be great news for us either as Tsuji will then have to come up with an effective assay to ensure full maturity of these follicles. But if they succeed, they will then need the aid of hair transplant surgeons. To be honest, I'm not an expert on hair transplants. Others may have a better understanding of how much density can we achieve with our current HT technology. From what I've heard though, there's a HT method called "dense-packing" where they can put somewhere around 80-100 hairs in a 1 cm2 area which is amazing to say the least (of course as long as you have unlimited donor supply lol)

Hope that helps and answers your questions

Desmond, did you know Dr. Nigam said he's willing to sponsor you to go to India and scrutinize him? From HS:

"I can also sponsor(with return air ticket and hotel) roger,freddie or desmond or spencer,or anybody hair loss community decides, who may be considered neutral scientifically knowledgible to thoroughly scrutinized me, my team, my clinic, my lab and my association once and for all..."

[HairBane]

AWESOME! I'm gonna go out and do my best to get laid while having women stare at my hairline!

Best 1-2 years of my life!

:/

</sarcasm>

I hate this disease.

I've been meaning to ask you about your use of RU. Have you had side effects from it? What makes RU less dangerous for libido and such compared to Finasteride? Have you seen much in terms of results?

And 2 years is nothing in the grand scheme of things. When my dad was balding, he just.. had to go bald, there was nothing. We have potential cures just out of arm's reach.

[hellouser]

Just want to remind everyone to live their life over the next 2 years.

Don't sit around putting everything on hold until 2015

AWESOME! I'm gonna go out and do my best to get laid while having women stare at my hairline!

Best 1-2 years of my life!

:/

</sarcasm>

I hate this disease.

[yeahyeahyeah]

Yeah exactly, less than 2 months before 2014... I hope 2014 will confirm everything!

Just want to remind everyone to live their life over the next 2 years.

Don't sit around putting everything on hold until 2015

[sdsurfin]

?

Informative post, but again a whole ton of assumptions. I'm not sure that culturing DP cells is really the only roadblock. I'd have to hear that from a guy like Jahoda, he seems to think there's still a ton of work to be done on a lot of aspects, and considering the fact that they only grew a few thin white hairs it looks like he's correct. They don't know what the new follicles will do in a scalp thats susceptible to balding. at all. Even the tsuji follicles could turn out to be crap once implanted in a balding scalp. I'm pretty perplexed as to why they cant find someone to volunteer and let them do the same experiment on a human scalp now, and see what the difference is. Also, where are you getting that info about CB? When I emailed the company they said that they have not even filed an IND for alopecia yet. which means many years until a possible release. Trials have not even begun, and no way they will be finished in 2015. the acne formula (as confirmed by them) is not the same potency nor is it in the same vehicle.

Hey Tomb Sorry for the late reply...been so busy man

To best answer your question, I think it's best to summarise the greatest leaps we've had in the last 10 years of hair multiplication research:

1) We now know with certainty if Harvested human DP cells maintain their inductive properties, they can form a fully functional 'terminal' hair follicle with all supporting structures including sebaceous glands and melanocytes (for pigementation). This is what was shown in Christiano/Jahoda's 2013 study.

2) A fully functional bio-engineered hair follicle will attach to all surrounding nerves and muscle fibres every single time (100% success rate). (Tsuji Lab 2012 "Hair germ method")

3) Attaching a 'nylon thread' to the 'hair germ' during implantation had a 70% success rate in terms of controlling the angle and hairs actually breaking through the skin. It's still not perfect but I'm sure they'll be tweaking it to get close to 100%! (Tusji labs FUT experiment in 2012)

Based on these findings, we can be more than certain that solving the angle and colour issue is far easier than the DP culturing difficulties.

You can call the DP culturing problems as the FINAL FRONTIER Solving it is a GREAT leap forward (cracking this code will advance us by decades!)

And luckily it seems (and to my surprise) the Japanese have managed to crack the DP culturing roadblocks by adding specific growth factors to the culture medium. I posted it earlier this week in this thread (Ohyama's study in 2012)

To be honest, to me at least it seems most of the work is done! We just have to watch them finalise their methods and protocols for a preclinical trial combining both the Tsuji 'hair germ' method and Ohyama's DP culturing method using human cells on human skin graft! If this trial is proven successful, then it's just a matter of jumping some regulatory hoops to reach those of us waiting so ever patiently for a solution to this nightmare!

2015 will be an action-packed year! Kind of like 2012! By the end of 2015 we will know:

- Replicel's ultimate potentials
- Histogen's Estimated Asian Release Date (hopefully around 2016)
- CB-03-01's Phase 2 Alopecia trials END and final data is published!
- And possibly if we're lucky Tsuji lab will begin some of their preclinical trials in preparation for their first-in-man trials

And to think of it, 2015 is actually not that far away

To a hairy future! Hip pip.....

[Artha]

Yup, only a little over a year to go seeing how we're close to 2014.

Yeah exactly, less than 2 months before 2014... I hope 2014 will confirm everything!

[Sogeking]

Desmond can you tell us how does this tie in with current Tsuji Lab 'hair germ' method and Ohyama's DP culturing method?

http://medicalxpress.com/news/2013-11-regrow-hair-cartilage-bone-soft.html

[hellouser]

And to think of it, 2015 is actually not that far away

Yup, only a little over a year to go seeing how we're close to 2014.

However, thats NO excuse for any of these biotechs to continue with the snail paced progress or give them any hint that we'll 'patiently' wait any longer, everything should have been released by now.

[Tomb10]

thanks desmond,

but my second question, when they had used a human scalp instead of a bald mouse, would there have started to grow hair, or is that just still unknown?

i read in an interview with colin jahoda that he isn't the man who will bring this to the market. will tsuji lab's do this?

and for the density, if they can't use "hair germs'' but need mature hairs, the hairtransplants get better with the year, so when this is available for us, i think they can achieve a good density. but ofcouse that will be a lot more expensive.

[Desmond84]

With regards to the density problem:

There are TWO possible ways that Tsuji will try to tackle the 'Density' issue. They'll be testing the theories in their preclinical trials to see which one is more successful.

If Tsuji is able to implant 'hair germs' into scalp and they can mature within the scalp to an actual hair follicle then there's nothing to worry about! They have learnt in their previous study that implanting 28 germs in a 1 cm2 area would give you on average 120-150 hairs, which is pretty much your juvenile hair density!

If they couldn't do that and have to place the hair germs in some kind of assay to grow them to maturity, they then have to perform a FUT to transplant these hair follicles. Under such circumstances, the hair density will depend on how advance our hair transplant methods are. This will not be great news for us either as Tsuji will then have to come up with an effective assay to ensure full maturity of these follicles. But if they succeed, they will then need the aid of hair transplant surgeons. To be honest, I'm not an expert on hair transplants. Others may have a better understanding of how much density can we achieve with our current HT technology. From what I've heard though, there's a HT method called "dense-packing" where they can put somewhere around 80-100 hairs in a 1 cm2 area which is amazing to say the least (of course as long as you have unlimited donor supply lol)

Hope that helps and answers your questions

[Desmond84]

Thanks for the answer.

and a new question,

When they use this method at this moment on an human scalp, is it then certainly that there will grow new hair?

maybe desmond can give also his opinion about this.

Hey Tomb Sorry for the late reply...been so busy man

To best answer your question, I think it's best to summarise the greatest leaps we've had in the last 10 years of hair multiplication research:

1) We now know with certainty if Harvested human DP cells maintain their inductive properties, they can form a fully functional 'terminal' hair follicle with all supporting structures including sebaceous glands and melanocytes (for pigementation). This is what was shown in Christiano/Jahoda's 2013 study.

2) A fully functional bio-engineered hair follicle will attach to all surrounding nerves and muscle fibres every single time (100&#37; success rate). (Tsuji Lab 2012 "Hair germ method")

3) Attaching a 'nylon thread' to the 'hair germ' during implantation had a 70% success rate in terms of controlling the angle and hairs actually breaking through the skin. It's still not perfect but I'm sure they'll be tweaking it to get close to 100%! (Tusji labs FUT experiment in 2012)

Based on these findings, we can be more than certain that solving the angle and colour issue is far easier than the DP culturing difficulties.

You can call the DP culturing problems as the FINAL FRONTIER Solving it is a GREAT leap forward (cracking this code will advance us by decades!)

And luckily it seems (and to my surprise) the Japanese have managed to crack the DP culturing roadblocks by adding specific growth factors to the culture medium. I posted it earlier this week in this thread (Ohyama's study in 2012)

To be honest, to me at least it seems most of the work is done! We just have to watch them finalise their methods and protocols for a preclinical trial combining both the Tsuji 'hair germ' method and Ohyama's DP culturing method using human cells on human skin graft! If this trial is proven successful, then it's just a matter of jumping some regulatory hoops to reach those of us waiting so ever patiently for a solution to this nightmare!

2015 will be an action-packed year! Kind of like 2012! By the end of 2015 we will know:

- Replicel's ultimate potentials
- Histogen's Estimated Asian Release Date (hopefully around 2016)
- CB-03-01's Phase 2 Alopecia trials END and final data is published!
- And possibly if we're lucky Tsuji lab will begin some of their preclinical trials in preparation for their first-in-man trials

And to think of it, 2015 is actually not that far away

To a hairy future! Hip pip.....