Histogen's FINAL Phase I/IIa Results (2013)

[FearTheLoss]

If this is what it comes to.. histogen simply halts hair loss... as good as fin without sides.. (hopefully better than fin) than in my mind it's still a huge success.

The problem is, I doubt it will make it to the market if this is "all" it does...Propecia didn't generate near the profit that Merk hoped it would...so I doubt that a company would invest in histogen if it's another version of propecia..

That being said, if HSC could be distributed at a reasonable price, it may be appealing as there isn't the side effect concern and it's injections once a year or so...instead of a pill every day. Also, who knows what this could do if it were combined with fin or RU or another treatment.


I guess only time can tell.

[yeahyeahyeah]

I can't help but feel a little deflated at this news, to be honest. I still have great hope for Histogen but, well... :\

We don't know the percentage change from baseline to begin with.

Could be 50% + 2.5%?

[Desmond84]

Clinical chemistry showed no indication of
toxicity or blood/urine abnormalities in the
general patient population following both sets
of HSC injection. Clinical evaluation of blood
serum chemistry, hematology and urinalysis
showed no changes from baseline over the course
of the treatment. Figures above show the serum
blood chemistry and hematology values obtained
at baseline (pre-treatment), 4 weeks and 12
weeks. No evidence of toxicity is observed in any
of the clinical indicators


So, how is it that Histogen can come to these conclusions and in the very same poster demonstrate that Follistatin is inhibiting hemoglobin levels?

Anyone know what Max% OD stands for?

No evidence of toxicity was observed in the Phase I/II trial by using merely 8 shots of HSC...The chart about Follistatin is most likely from their Animal toxicity studies, where they inject large doses of the drug to observe possible risks of toxicity!

[Desmond84]

I personally think Histogen will have a place in our current armament against MPB...but it will NOT be capable of doing what we initially hoped it to be:

"A single session providing 20% increase in hair count for 2 years across the crown, vertex and temporal areas"

The next phase is the "Dose-range finding" study...this is going to be significant for us, because Histogen will find out how much HSC they can inject without risking Haematological adverse effects!

There is another solution to their problem as well! The main culprit for dropping Haemoglobin count is Follistatin! Maybe they can reduce the concentration of Follistatin in order to enable treatment of a much larger surface area! Hopefully reducing the concentration of Follistatin will NOT reduce the efficacy all that much!

[The Alchemist]

Clinical chemistry showed no indication of
toxicity or blood/urine abnormalities in the
general patient population following both sets
of HSC injection. Clinical evaluation of blood
serum chemistry, hematology and urinalysis
showed no changes from baseline over the course
of the treatment. Figures above show the serum
blood chemistry and hematology values obtained
at baseline (pre-treatment), 4 weeks and 12
weeks. No evidence of toxicity is observed in any
of the clinical indicators


So, how is it that Histogen can come to these conclusions and in the very same poster demonstrate that Follistatin is inhibiting hemoglobin levels?

Anyone know what Max% OD stands for?

[Phatalis]

Anyone who was expecting Histogen to grow thick hair on a bald scalp is delusional. Such a treatment may never exist. However, it clearly seems that HSC is, at the very least, capable of halting hair loss without the side effects of currently available medications. It also appears that it is effective at thickening native hair and even achieving some regrowth. And instead of taking a pill or slathering some gunk on your head every day, you might be able to take this treatment only once or twice a year. That's a pretty big deal.

As for the people freaking out about the price, this would probably end up being a product like botox - you go in once or twice a year and get a little touch up and then you're done. Like botox, it's not going to be super cheap but it's also not going to be prohibitively expensive. And no, you won't have to travel to their lab to get injections - they'll probably be in every dermatologist office on the planet, along side the botox, the fillers, etc.

If this is what it comes to.. histogen simply halts hair loss... as good as fin without sides.. (hopefully better than fin) than in my mind it's still a huge success.

[bigentries]

Actually he ripped out his own hair each time Marge told him she was pregnant.

I guess as a kid (with full density) was unable to appreciate the beauty of NW3 Homer

[ryan555]

Anyone who was expecting Histogen to grow thick hair on a bald scalp is delusional. Such a treatment may never exist. However, it clearly seems that HSC is, at the very least, capable of halting hair loss without the side effects of currently available medications. It also appears that it is effective at thickening native hair and even achieving some regrowth. And instead of taking a pill or slathering some gunk on your head every day, you might be able to take this treatment only once or twice a year. That's a pretty big deal.

As for the people freaking out about the price, this would probably end up being a product like botox - you go in once or twice a year and get a little touch up and then you're done. Like botox, it's not going to be super cheap but it's also not going to be prohibitively expensive. And no, you won't have to travel to their lab to get injections - they'll probably be in every dermatologist office on the planet, along side the botox, the fillers, etc.

[Buster]

Let's be scientifically precise here. Homer has telogen effluvium - not MPB - despite what that kind of a horseshoe would suggest in our own universe!!

Actually he ripped out his own hair each time Marge told him she was pregnant.

[Arashi]

Remember Dolly? The human genome? they haven't really translated into new treatments. We know a lot more thanks to those achievements, but people were also expecting the first bio-engineered human to arrive in a decade at most

That's not a fair comparison, it's more ethics that kept things back. Scientists are now able to flip on/off any gene in ANY organism, including humans (which IS being done as we speak, for example in a phase II clinical trial to make humans resistant against HIV/AIDS, see http://www.sangamo.com/pipeline/sb-728.html for example). And cloning humans is theoretically possible as well. It's just ethics keeping that back.

[bigentries]

Let's be scientifically precise here. Homer has telogen effluvium - not MPB - despite what that kind of a horseshoe would suggest in our own universe!!

No, it's MPB, he was using minoxidil

Edit: My bad, it was dimoxinil it's evil brother that actually works

[clarence]

The thing with Aderans is that, I can't see how they could hide good results. If someone was growing hair like that Simpson's episode where Homer got his hair back, in the middle of America, during the internet era, everyone would know it was happening, non-disclosure agreement or not. The only reliable insider 3 years ago said the results were very mediocre

Let's be scientifically precise here. Homer has telogen effluvium - not MPB - despite what that kind of a horseshoe would suggest in our own universe!!

[bigentries]

But both Team Tokyo and Jahoda et al already succeeded (!!) at bio-engineering a human hair follicle, growing human hair. They already did it ! It's not science fiction, it was already done ! So getting that to market, it should be possible within 10 years.

Again, you are being overly optimistic. With this kind of news I would have guessed people would be starting to get more realistic

Remember Dolly? The human genome? they haven't really translated into new treatments. We know a lot more thanks to those achievements, but people were also expecting the first bio-engineered human to arrive in a decade at most

[Arashi]

Is it really pessimistic? It means kids born today wouldn't need to worry about baldness!
Let's be realistic, every company that got to phase II took a decade to get there, I don't see how new possibilities would arrive to the market in, let's say, less than 15 years

The thing with Aderans is that, I can't see how they could hide good results. If someone was growing hair like that Simpson's episode where Homer got his hair back, in the middle of America, during the internet era, everyone would know it was happening, non-disclosure agreement or not. The only reliable insider 3 years ago said the results were very mediocre

Being overly optimistic, I think CB is still in the game, and after the acne trials end, everyone will be able to get it off-label

But both Team Tokyo and Jahoda et al already, independently succeeded (!!) at bio-engineering a human hair follicle, growing human hair. They already did it ! It's not science fiction, it was already done ! So getting that to market, it should be possible within 10 years.

[bigentries]

Agreed that silence is a very bad sign in this business. Companies with success usually like to boast them ASAP and publicize any favorable interim result as soon as they can. However I don't agree that this pushes back HM 20 years. Don't forget that Jahoda already succeeded at bio-engineering a human hair follicle and have it grow on human skin !! They just need to optimize it and run trials. But 20 years is way too pessimistic here for something that they've already succeeded doing !

Is it really pessimistic? It means kids born today wouldn't need to worry about baldness!
Let's be realistic, every company that got to phase II took a decade to get there, I don't see how new possibilities would arrive to the market in, let's say, less than 15 years

The thing with Aderans is that, I can't see how they could hide good results. If someone was growing hair like that Simpson's episode where Homer got his hair back, in the middle of America, during the internet era, everyone would know it was happening, non-disclosure agreement or not. The only reliable insider 3 years ago said the results were very mediocre

Being overly optimistic, I think CB is still in the game, and after the acne trials end, everyone will be able to get it off-label