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Also, I was wondering, do you plan to offer your therapies without the use of growth factors ? I mean if it wears off this quickly, I'd rather not have any growth factors at all. That little effect is surely not worth the risk of your health (in my opinion). Hence I was hoping, are you planning to do a test case, just like Tom's, without the use of growth factors ? This would also mean, if effective, you could offer such therapy in Europe, since currently these growth factors are illegal there.
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Sitting with the web guy and marking pics...a different role for me..
May be i can present half pics today..counts of total grafts ,singles,doubles,triples.density at normal donor,recipient,extracted donor area..i will post on monday..as.. by 12am at night we will be able to finish part documentation...
Regards donor regen,this is a case of invitro with extracted graft ,removed from it's blood supply,bisected and implanted...bisection point is little different from my 15 grafts patch test.
donor and recep regen will be early where there is root ,the dermal papilla,and late where there is upper half of follilce implanted...
2/3weeks(some will happen early)where dermal papilla is implanted...others late where upper half implanted..but before the marks subside at donor we will see regen in few extracted/implanted areas..
..Tom met 2 patients today, with early 3 month result of stemcell..one male patient and another female...
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Thanks for all the documentation Dr!
So you mean that the regeneration is faster with bisected grafts (with dermal papilla) than with whole grafts (normal fue)? Why is that?
I thought your invitro bisected grafts would regenerate like normal fue grafts with an initial shedding and then regrowth in 3-6 months? Is this not the case?Comment
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Arashi,
I read Histogen results today.
I was about to talk to J
onathan(cso histogen) this week,will discuss in detail their result..as i am not much aware about them except there last results and what growth factors they are using.
It is a big topic to discuss...may be next week...
They were using allogenic,not autologous ,were they injecting directly into telogen follicle...
As on today,real hope is stemcell,dp culture..and support it with doubling,where results are not satisfactory...as HM evolves.
I am using growth factors to possibly boost my therapy..not dependent
on it for hair growth..have not used gf independently..till now, to see hair regen..
Vascular endothelial growth factors are for increasing blood supply..some growth factors are good for scarless procedure...
It is better to attack AGA holistically rather than in isolation...
Like using anti androgens and anti inflammatory to supress the damaging effect of the same on AGA...,
Use of doubling with hm, if certain scalps do not respond to hm.
I believe one has to use combination therapies..as i introduced dp cells into hm ,results improve,i added gf into hm,ecm for healing...and later will introduce 3d spheroidal culture instead of 2d dp culture...
Regards safety.i am not using wnt7a which histogen is using..
Will ask jonathan,in how much time the drop in haemoglobin is back to normal levels,in how many cases the drop is there is their any correlation with any specific finding,anyway all ht patients do their blood counts...need to monitor periodically when on growth factor,was the wnt responsible for drop in haemoglobin level,how much was the drop...
The good news is there were no major side effects noticed in 48 weeks,like tumour etc.Even fina has it's side effects..which revert after stopping it..
Will definitely speak to jonathan ..to find out more details..
If the patient desires growth factor can be avoided..
But Arashi,i want to focus on research and improvement..not business expansion, as of now..it is better if patients travel to mumbai,than i travel all over...
Now i understand after seeing histogen results ,why members doubt newer therapies ....
dr gail is a learned researcher...but i wonder ,how come big companies put all their money and effort in one basket ...unless they have done atleast small minitrial at the clinic level on humans and not mouse...
I have to get convinced with results..before i put all my effort,money,reputation on stake...
Remember fut,fue,hst were all created by clinicians,who utilised the work of researchers...and not by big corporates...
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Friends,
Kindly find below pics of TOM VERCETTI,the forum member,who did invitro hair doubling with progenitor stem cells and dp cells,ecm etc ,for hairline and temples...
Posting only pics tonight,as it is late here in mumbai...
Details regards.. number of grafts.. doubled,singles,doubles,triples,..donor density,recpient density,normal scalp density on monday...
HE WILL GET DOUBLE THIS DENSITY WHEN HE REVISITS AFTER 6 WEEKS,AS HE HAD DECIDED TO COVER APPROX 40 TO 50 SQCM NON HAIR AREA OF TEMPLE AND HAIRLINE TO COVER WITH LIMITED GRAFTS HE ENROLLED FOR.
He decided,against my advice to first cover.. less area.. with more grafts.. and than may be go for further extension ,but he was predecided on a particular lower level of hairline,specially laterally...
Pics were taken after clearing the ecm paste and blood around implanted and extracted area...hence wavered hairs..
You can see in the bisected grafts, that some part of root is present in both the bisected parts..(such bisection has not been performed before by anyone)
One improvement in technique clicked my mind while doing TOM'S case..now for doubling ,i won't need incisions for recipient with blade or needle..as i would place all the tiny lower half of the bisected graft at recipient by injecting them with storage solution at the recipient rather than creating incisions first..as it is tiny enough to pass through 21 number needle...hence we can have no incision marks,less microscarring,quick healing,higher density,faster procedure...you can observe on the anterior hairline ,i have injected at lower half of bisected follicle on last day..hence tiny black roots without surrounding oedema, no mark, no redness at that injection site...(this non incision based implantation is also new ,original innovations ,as far as i know..)
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injections with progenitor stemcells,dp cells,gfand ecm..
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I'm a bit confused Dr Nigams. If I understand correctly you've applied your Invitro technique and hence extracted the WHOLE graft and then split those after the extraction. But what did you do with both halves ? Did EVERYTHING go into his hairline ? Or did you plant grafts back into donor too ?Comment
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I could get time to only mark, one donor macro with circles..yes red circles are few in that pic..
as the blood,and macro image makes little difficult to confirm the tiny bisected grafts as of now..
but videoscopic pics are easy to circle red,as on zooming in..i can see the bisected upper half over the injury mark..
The videomicroscopic pics are from left to right...in sequence,for 1st,2nd,3rd and fourth Bun(strip shaved area)..
i will post them with exact sequence ,with labeling on monday,so that you can form an image..with comparison with its macro counter image.....
i think,for the first... two/three weeks ...we can monitor the the follicle regen on marks of extractions at donor...by the time, we will have to find the way ,how do we monitor the rest..
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Although I'm not religious, hehe, I'm still praying Tom's case will be a huge success ! The hairloss community deserves it !
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