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Dr nigam, thank you undoubtedly for the huge commitment you're putting in the documentation; advice from moderators that now is the time, as well as for Gho, to create a section just for Dr. Nigam. However, I'm not understanding a lot and I'm having a headache with all these technical terms what you have done for Tom!
Someone in the forum, type Arashi, could make a summary of situation for lay people who do not understand english well technician (I'm not English).
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Seriously - what the f*** is wrong with you??Bisected grafts for invitro donor doubling
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You labled these photos with "Bisected grafts for invitro donor doubling" but I can't see not even 1 "bisected graft"!
Practically ALL grafts in both photos show completely intact FUE grafts!
I can see the completely intact follicle bulbs on one end, and completely intact upper parts including the clipped hair shafts on the other end of all grafts!
None of the grafts in both photos is "bisected" in one or the other way!Comment
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I like this comment from you,and feel creatively satisfied.
Do you know my ceo,TOM and others asked me why are you posting all the USP of your technique in open..But i still posted.
Thats the speciality of the technique...that such an experienced person like you is not able to make out the difference of bisection.
I am advised not to disclose ..but i will...because it is so exciting...
Have a close look at the second link on your post...
You can see tiny bisected grafts with lower part of dermal papilla..now as the neck of the follicle around root is cut..it looks little elongated...
And the upper bisected follicle in the first link you posted still has some part of the root...
Imagine the grass being extracted from your garden...now bisect the grass from the level of the beginning of it's root..in such away..that both parts have some attached root..both will grow..especially if..the lower part is supported with bulge and other stemcells it is missing after bisection and the upper part is supported by extra dp cells which it is missing after bisection...
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DR. Nigam,
I know this is not the right thread, but could you give us a bit to explain the results of Histogen, these results do not appear to me that they are so bad. And you are competent to answer.
thanks
And another thing ....
Do not pay attention to the IM, he's just ... dumb and blind boy!Comment
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Veca,
I will be able to answer your question regards histogen..after speaking to the chief scientific officer of histogen..Jonathan Mansbridge,which i will do this week.
I feel sorry for Dr Gail Naughton...they should find the right growth factor and it's dosage and safety..by doing a small clinical trial at a clinic as a medical procedure(which is legal) ,
once they are convinced with the outcome...than they can go all out with money and their effort to get FDA approval with the clinical trial to market as drug..rather than loosing all the money...and the time and the effort put in...
Desmond84, rightly pointed out in another thread ..that corporates first think about big business ideas..and what profit it can make...they forget first you have to focus efficacy and cure...than plan a mechanism to create the right business idea to monetize...
Everybody rushes to patenting their process..before even they are 100% sure of the efficacy...so that they can sell their patent by creating hype..
Replicell was lucky to to sell their patent this week without any proof of its efficacy...shisiedo is a cosmetic company...it can create profit even with mediocre efficacy...by marketing...
Anyway cosmetics cannot do anything to human cells..or else it will be classified as drug...which cannot be sold over the counter...
Only a drug can do something to/with human cell..to be prescribed by licensed physician..so shiseido..can create a hype with a special ingredient in their cosmetic product..regards dps..and make huge profits..
Such a cosmetic product will not be any use to MPB sufferers but could be profitabily sold to thinning hair, hairloss prevention,increasing quality of hair..to potential customers...
Histogen is using allogenic growth factors...ofcourse there is a missing link..in their GF..ingredients and injection technique..
Aderans(lab plus clinic with bosley) have shown 60% success in patients injected autologous stemcells,i am addind dp culture and dp cells to it..why will my sucess be not better in coming months as i give my first 2d dp culture injection to my patient this week and observe his result.
I will add the right combo of growth factors after few months..as i study more and do miniclinical trial,plus if at all i focus on growth factors in future..my personal hypothesis is,the GF should be injected under photon microscopic view directly into telogen follicles,and into thinning follicles with use of magnification...targetted delivery is important as limited dose can be injected..over a period of a year..and monitor haemoglobin levels...in cases if haemoglobin level is dropped..stop further injections..in other cases if it is normal,repeat the injection...19% efficacy for the first year was not bad..need repeat injection..and modifications..but i will call dr gail and suggest..first do miniclinical trial at clinics on human scalp..and i can help her..doing so in mumbai...and through my friends in east europe(surprise..!) and dominic republic..where the legality is even more relaxed than india..i am discussing with certain biotechs in the above locations to set up a lab in future...
Atleast one good news i take is no major side effect note even after using noggin and wnt7a...real effective growth factors will be autologous..created by culturing dp for few weeks in the lab...
Hairloss community is forgetting..corporates will focus on products..which they can patent and make profit...unlike clinicians who see patients daily and can easily monitor and see efficacy of newer techniques and efficacy of... off the label use of products(ru,lattise,cb,tm,gf,keto)....
But corporates are not first... focussing to cure mpb..but their first motivation is can we profit and can we patent...and than they plan their research strategy..which is monitizable..
Acell,ecm,prp were banking on autologous growth factors effect in their product...which is already proven and approved by FDA for healing..and not for hair regen as few docs some claim..i use the same for scarless process and better healing...
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Dr. Nigam,
Thanks for the nice response. All you have written makes perfect sense. Corporates have only one goal ... money ... and that's logical ... with this strategy, they attract the majority of potential consumers. Let's think ... if 40% of men have a problem with hair loss, and only 4% of us looking for some help and therapy, and of those 4%, only a few hundred members of this forum trying to get to a true cure ... for them (for corporates), we are a small drop in the ocean, and we are not interesting.Comment
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On the other hand ... if your results prove to be successful ... uhhhh, I can not imagine how it can change the entire industry of hair restoration. Truly from the heart I want that to happen, you deserve to get it. You have the full support of almost all members of the forum, do not disappoint us.
By the way ... I'm from Eastern Europe, if you need anything, I'm here to help ...Comment
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Once again.
So you mean that the regeneration is faster with bisected grafts (with dermal papilla) than with whole grafts (normal fue)? Why is that?
I thought your invitro bisected grafts would regenerate like normal fue grafts with an initial shedding and then regrowth in 3-6 months? Is this not the case?
Also another question: How can you place the smaller half of the bisected graft (the one you inject) in the right angle when it is so small? Before you started to inject these (before TOM) this must have been really hard?Comment
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Give it a rest mate you're boring...Comment
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