7th World Congress for Hair Research (2013)

[clandestine]

Or Highlander, Scorpion.

[Conpecia]

has to be technical. no way they'd let IM survive this long and block Des...

[Artista]

Gare' thats OK. you showed concern for Des' ...we are all just human.
Thanks for adding to the idea that it may be technical after-all.
Hang in there Des'

[garethbale]

Lets not jump to conclusions just yet..It very well may have been technical. As you members have stated, Desmond have bee a positive spirit here. This will be sorted out, Im sure of it.

I just tried to log in and couldn't, so it probably is technical.

Can I withdraw my previous comment!

[Artista]

Lets not jump to conclusions just yet..It very well may have been technical. As you members have stated, Desmond have bee a positive spirit here. This will be sorted out, Im sure of it.

[garethbale]

This is a joke surely! Why would Desmond be blocked?

Absolute disgrace if his account is not unblocked. He is the best poster in here

[Henkeh91]

Wow.. I'm shocked! It has to be some kind of mistake, you are providing this forum with great news and optimism. I really hope that this isn't your last post.

You got my support Desmond! Always

[Artista]

Hi Desmond, Could it have been a technical issue? You certainly have been positive and have provided much information here. Make sure that you speak with the admins about this before jumping to conclusions bro

[Desmond84]

To all my friends on BTT,

Unfortunately, as of 11th of May (last day of the hair congress) Baldtruthtalk.com BLOCKED my IP address without any notification to prevent me from posting on this site. This was an absolute shock to me as my posts have been mostly informative in the current field of hair research in the scientific community and I have stated repeatedly my utter respect for Spencer Kobren and his accomplished efforts for the hairloss community.

I personally believe that the forum has EVOLVED over the past year to a much more productive and scientifically oriented discussions to the point where our discussions get relayed on the The Bald Truth show and almost every other hair loss forum out there. I was amazed at times to see our discussions being posted and translated on French, Dutch and German forums

This has been thanks to an influx of members with backgrounds in Biomedical science, Genetics, Pharmacology, Drug Development and Regenrative Medicine….keeping discussions extremely engaging and positive!

I hereby ask Baldtruthtalk to please unblock my IP address or at least provide a reason as to why this has happened. I think what is happening right now on BTT is a great thing and Spencer and BTT team should embrace these exciting times rather than try to suppress it…

Baldtruthtalk is evolving…let’s evolve with it

Also, to all the members who have supported me during the past 8 months I’ve been a member of this great supportive community…please voice your opinions! Without you guys I am powerless…

Let’s hope this is not my final post…(And if it is, thanks to everyone who have been so kind to me! You guys most definitely changed my life around)

Sending all my balding brothers and sister lots of love from an Internet café nearby!

- Desmond

[drnigams]

WCHR 2013 Topic Follicle neogenesis by DP Cells @Dr. Nigam's

Kindly find below the abstract which was discussed at WCHR 2013 Edinburgh which I visited recently and had a interaction with Collin Jahoda on the same. Scientific minded members can discuss it further for hair follicle neogenesis

P220

Human hair follicle neogenesis using microvironmentally reprogrammed dermal papilla cells


click the below link for enlarge image

http://www.drnigams.net/images/poster/Large/1.JPG

click the below link for enlarge image

http://www.drnigams.net/images/poster/Large/2.JPG

CA Higgins, CA Jahods2 and AM christiano 1.3 Department of Dermatology, Columbia University, new York, USA , 2 Biological and Biomedical sciences, Durham University, Durham UK and 3 Genetics and Development, Columbia University, New York,USA

Hair Follicle (HF) neogensis refers to the generation of an entirely new HF in recipient skin using HF dermal papilla (DP) cells. This has been extensively demonstrated in rodent skin , either using intact DP or using intact Dp or using caltured DP cells. In contrast , HF neogensis in human skin has not previously been achieved using human cells. We performed global transcriptional profiling of both intact and cultured Dp cells using Affymetrix U133 Plus 2.0 array , which revealed several pathways expressed in intact5 DP , which are capable of neogenesis , but absent in caltured cells, that lack the micro environmental and anatomical context of intact DP is to grow the cells in hanging drops, which results in the formation of DP spheroids. We then profiled DP spheroids for changes in gene expression and determined that the average correlation coefficient between the transcriptomes of intact DP and the cultured cells is 0.42 , whereas that between the intact DP 3D culture. To evaluate whether recapitulation of the DP signature equated to a restored inductive potential, we established a contextual human – to – human HF neogenesis assay that could be used to assess the inductive capacity of human DP cells in human skin. When we micro implanted DP spheroids into recombined foreskins placed onto the back of SCID mice, we observed marked HF neogensis by 6 weeks, showing for the first time that intact human DP can induce de novo human HFs. We conclude that the partial restoration of the transcriptional profile in human Dp cells, achieved simply by growing the cells in a 3d spherical microenvironment, is sufficient in some instances to restore the inductive capacity of Dp cell cultures and elicit human HF neogenesis.P220

Human hair follicle neogenesis using microvironmentally reprogrammed dermal papilla cells



CA Higgins, CA Jahods2 and AM christiano 1.3 Department of Dermatology, Columbia University, new York, USA , 2 Biological and Biomedical sciences, Durham University, Durham UK and 3 Genetics and Development, Columbia University, New York,USA

Hair Follicle (HF) neogensis refers to the generation of an entirely new HF in recipient skin using HF dermal papilla (DP) cells. This has been extensively demonstrated in rodent skin , either using intact DP or using intact Dp or using caltured DP cells. In contrast , HF neogensis in human skin has not previously been achieved using human cells. We performed global transcriptional profiling of both intact and cultured Dp cells using Affymetrix U133 Plus 2.0 array , which revealed several pathways expressed in intact5 DP , which are capable of neogenesis , but absent in caltured cells, that lack the micro environmental and anatomical context of intact DP is to grow the cells in hanging drops, which results in the formation of DP spheroids. We then profiled DP spheroids for changes in gene expression and determined that the average correlation coefficient between the transcriptomes of intact DP and the cultured cells is 0.42 , whereas that between the intact DP 3D culture. To evaluate whether recapitulation of the DP signature equated to a restored inductive potential, we established a contextual human – to – human HF neogenesis assay that could be used to assess the inductive capacity of human DP cells in human skin. When we micro implanted DP spheroids into recombined foreskins placed onto the back of SCID mice, we observed marked HF neogensis by 6 weeks, showing for the first time that intact human DP can induce de novo human HFs. We conclude that the partial restoration of the transcriptional profile in human Dp cells, achieved simply by growing the cells in a 3d spherical microenvironment, is sufficient in some instances to restore the inductive capacity of Dp cell cultures and elicit human HF neogenesis.

[Artista]

Hi Dr Nigam, thanks for posting but I could not open that link.

[drnigams]

Histogen Poster presentation at WCHR 2013@Dr. Nigam's

Dear Members,

Kindly find below the Histogen presentation at WCHR 2013, Edinburg 2013 sent to me by their corporate communication.

I am not aware what results have they published in Oct 2012 and are these results any different from 2012 presentation or no?

Hopefully I & Jonathan Mansbridge, (Chief Scientific Officer, Histogen) will be speaking on phone this week and see what best I can come out with for my hair loss community friends for the earliest access, once I am convince with their results in person.


click below link for enlarge image

http://www.drnigams.net/images/HTG_E...ic/Large/1.jpg

[garethbale]

Dr Nigam

Why are all the hair treatment companies so reluctant to keep hair loss sufferers informed about what is going on?

[santos]

Good news. When will all of this be on the market Dr.Nigam?

[youngin]

I wish there was a like button on posts so I could like your posts Dr Nigam. Thanks for staying optimistic and keeping our community informed.