7th World Congress for Hair Research (2013)

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  • yeahyeahyeah
    Senior Member
    • Nov 2011
    • 1776

    Originally posted by 534623
    That's so far the only legit "news":

    >>>>>>>>>>>>>>>>>>>>>>>>>>
    As one of the organizers of WCHR2013 may I contribute the discussion.
    My duties meant I didn’t get to as many of the sessions as I would have liked but I have a fair idea of what is going on so just a few thoughts in response to some of the points that have been raised in previous posts.

    1. Around 600 people attended the meeting but not all were researchers (e.g. dermatologists, trichologists, alopecians who are interested in the field but not actively involved in research).

    Hair research is a diverse field and not all those involved are working on AGA. These include those working on other clinical problems, such as scarring alopecia and alopecia areata, developmental biologists who use the hair follicle as a model, and cosmetic scientists to name some.

    2. Despite the popular concept, there is not a lot of money in hair research and I doubt any of the academics involved have got rich from doing it. Research is expensive and the money has to come from somewhere. Medical grant-giving bodies are very unlikely to fund research into male AGA so it comes either from piggy-backing on other projects or from commercial sources. Industry is only likely to provide funding if it sees a return on investment – this does happen but it’s not a very reliable source and, like everyone else, scientists have to make a living.

    3. Current medical treatments for male AGA probably act mainly on the early changes in hair cycling and, in my opinion, there is little or no evidence that we can reverse follicular miniaturization. To achieve this is a tall order as it essentially means reversing an ageing process, something not yet achieved in other biomedical fields. This does not mean it cannot be done but I do not see it as being imminent (or even within the oft-quoted 5 years). The Holy Grail is to induce new follicle formation e.g. using various modifications around cell culture techniques. This has also proved very hard to crack in humans (and I have the scars on my arms to prove it) but progress is being made. However, it will be one thing to induce a hair follicle or two, quite another to induce the thousands that will be needed on a bald scalp all arranged in a cosmetically acceptable pattern.

    4. We need to be realistic. In my view progress is more likely to be by evolution than revolution. Prevention rather than cure (although I know this will not be much comfort to posters on this site). Combination treatments (highlighted at the meeting) and new medical treatments that overcome some of the shortcomings of what is currently available offer some hope.

    5. Side effects are a major issue. There is no treatment for anything that is devoid of side effects but the nature of hair disease means that risk has to be very low. This limits what we can do and those indulging in such treatments must recognize this.

    6. Recognise that there are ethical scientists of the highest calibre trying to make progress. But it is a small community.

    7. The field is plagued by false claims. It can be hard to know what to believe but, even if we have been pretty useless at coming up with better treatments, we can at least try to be objective about what is achievable.

    8. A highlight of WCHR2013 was the contribution from people with alopecia areata. They recognize it is not easy. Like them you need to be actively involved, not just complaining about our perceived shortcomings.


    >>>>>>>>>>>>>>>>>>>>>>>>>

    Yeah, that's everything for the coming years.
    4,5,6

    Is where the next step is going to be.

    Histogen -> minoxidil
    Aderans -> propecia without sides.

    Comment

    • UK_
      Senior Member
      • Feb 2011
      • 2691

      Originally posted by yeahyeahyeah
      4,5,6

      Is where the next step is going to be.

      Histogen -> minoxidil
      Aderans -> propecia without sides.
      Histogen -> Maybe
      Aderans -> Dead

      Comment

      • yeahyeahyeah
        Senior Member
        • Nov 2011
        • 1776

        Originally posted by UK_
        Histogen -> Maybe
        Aderans -> Dead
        They have pumped a 100 million into it, and it doesnt work.

        Unreal tbh.

        Comment

        • TO YOUNG TO RETIRE
          Senior Member
          • Mar 2013
          • 638

          Desmond where are you ?


          so guys we are sure no news to come from aderans or hsc?

          Comment

          • john2399
            Senior Member
            • Jan 2012
            • 521

            Originally posted by TO YOUNG TO RETIRE
            Desmond where are you ?


            so guys we are sure no news to come from aderans or hsc?
            There is news, we just don't know if it is good or even worth mentioning. Im sure tonight's show of the bald truth will talk about it.

            Comment

            • drnigams
              Senior Member
              • Nov 2012
              • 551

              TO YOUNG TO RETIRE,
              Histogen sent me the mail of the poster presented by them.
              Will post the same tmr,
              as i just returned to my clinic at mumbai...after 10 days of travel for the congress... a lot of back log work is pending at the clinic.

              Do not be disheartened ..even today..we can give you HM injections,dpcells and dp culture injections,growth factor injections for follicle regrowth , activation of dormanting follicles and much more to prevent or delay your progression of MPB.
              Be aware of pessimistic poster (you know whom i am referring to),some of them are front ends of certain clinics and want to sell u their HT by making you despair...

              Originally posted by TO YOUNG TO RETIRE
              Dr Nigam where are you?

              we all wait for your news

              Comment

              • youngin
                Senior Member
                • Nov 2010
                • 338

                I wish there was a like button on posts so I could like your posts Dr Nigam. Thanks for staying optimistic and keeping our community informed.

                Comment

                • santos
                  Junior Member
                  • May 2013
                  • 18

                  Good news. When will all of this be on the market Dr.Nigam?

                  Comment

                  • garethbale
                    Senior Member
                    • Apr 2012
                    • 603

                    Dr Nigam

                    Why are all the hair treatment companies so reluctant to keep hair loss sufferers informed about what is going on?

                    Comment

                    • drnigams
                      Senior Member
                      • Nov 2012
                      • 551

                      Histogen Poster presentation at WCHR 2013@Dr. Nigam's

                      Dear Members,

                      Kindly find below the Histogen presentation at WCHR 2013, Edinburg 2013 sent to me by their corporate communication.

                      I am not aware what results have they published in Oct 2012 and are these results any different from 2012 presentation or no?

                      Hopefully I & Jonathan Mansbridge, (Chief Scientific Officer, Histogen) will be speaking on phone this week and see what best I can come out with for my hair loss community friends for the earliest access, once I am convince with their results in person.


                      click below link for enlarge image

                      Comment

                      • Artista
                        Senior Member
                        • Apr 2010
                        • 2070

                        Hi Dr Nigam, thanks for posting but I could not open that link.

                        Comment

                        • drnigams
                          Senior Member
                          • Nov 2012
                          • 551

                          WCHR 2013 Topic Follicle neogenesis by DP Cells @Dr. Nigam's

                          Kindly find below the abstract which was discussed at WCHR 2013 Edinburgh which I visited recently and had a interaction with Collin Jahoda on the same. Scientific minded members can discuss it further for hair follicle neogenesis

                          P220

                          Human hair follicle neogenesis using microvironmentally reprogrammed dermal papilla cells



                          click the below link for enlarge image



                          click the below link for enlarge image


                          CA Higgins, CA Jahods2 and AM christiano 1.3 Department of Dermatology, Columbia University, new York, USA , 2 Biological and Biomedical sciences, Durham University, Durham UK and 3 Genetics and Development, Columbia University, New York,USA

                          Hair Follicle (HF) neogensis refers to the generation of an entirely new HF in recipient skin using HF dermal papilla (DP) cells. This has been extensively demonstrated in rodent skin , either using intact DP or using intact Dp or using caltured DP cells. In contrast , HF neogensis in human skin has not previously been achieved using human cells. We performed global transcriptional profiling of both intact and cultured Dp cells using Affymetrix U133 Plus 2.0 array , which revealed several pathways expressed in intact5 DP , which are capable of neogenesis , but absent in caltured cells, that lack the micro environmental and anatomical context of intact DP is to grow the cells in hanging drops, which results in the formation of DP spheroids. We then profiled DP spheroids for changes in gene expression and determined that the average correlation coefficient between the transcriptomes of intact DP and the cultured cells is 0.42 , whereas that between the intact DP 3D culture. To evaluate whether recapitulation of the DP signature equated to a restored inductive potential, we established a contextual human – to – human HF neogenesis assay that could be used to assess the inductive capacity of human DP cells in human skin. When we micro implanted DP spheroids into recombined foreskins placed onto the back of SCID mice, we observed marked HF neogensis by 6 weeks, showing for the first time that intact human DP can induce de novo human HFs. We conclude that the partial restoration of the transcriptional profile in human Dp cells, achieved simply by growing the cells in a 3d spherical microenvironment, is sufficient in some instances to restore the inductive capacity of Dp cell cultures and elicit human HF neogenesis.P220

                          Human hair follicle neogenesis using microvironmentally reprogrammed dermal papilla cells



                          CA Higgins, CA Jahods2 and AM christiano 1.3 Department of Dermatology, Columbia University, new York, USA , 2 Biological and Biomedical sciences, Durham University, Durham UK and 3 Genetics and Development, Columbia University, New York,USA

                          Hair Follicle (HF) neogensis refers to the generation of an entirely new HF in recipient skin using HF dermal papilla (DP) cells. This has been extensively demonstrated in rodent skin , either using intact DP or using intact Dp or using caltured DP cells. In contrast , HF neogensis in human skin has not previously been achieved using human cells. We performed global transcriptional profiling of both intact and cultured Dp cells using Affymetrix U133 Plus 2.0 array , which revealed several pathways expressed in intact5 DP , which are capable of neogenesis , but absent in caltured cells, that lack the micro environmental and anatomical context of intact DP is to grow the cells in hanging drops, which results in the formation of DP spheroids. We then profiled DP spheroids for changes in gene expression and determined that the average correlation coefficient between the transcriptomes of intact DP and the cultured cells is 0.42 , whereas that between the intact DP 3D culture. To evaluate whether recapitulation of the DP signature equated to a restored inductive potential, we established a contextual human – to – human HF neogenesis assay that could be used to assess the inductive capacity of human DP cells in human skin. When we micro implanted DP spheroids into recombined foreskins placed onto the back of SCID mice, we observed marked HF neogensis by 6 weeks, showing for the first time that intact human DP can induce de novo human HFs. We conclude that the partial restoration of the transcriptional profile in human Dp cells, achieved simply by growing the cells in a 3d spherical microenvironment, is sufficient in some instances to restore the inductive capacity of Dp cell cultures and elicit human HF neogenesis.

                          Comment

                          • Desmond84
                            Senior Member
                            • Oct 2012
                            • 987

                            To all my friends on BTT,

                            Unfortunately, as of 11th of May (last day of the hair congress) Baldtruthtalk.com BLOCKED my IP address without any notification to prevent me from posting on this site. This was an absolute shock to me as my posts have been mostly informative in the current field of hair research in the scientific community and I have stated repeatedly my utter respect for Spencer Kobren and his accomplished efforts for the hairloss community.

                            I personally believe that the forum has EVOLVED over the past year to a much more productive and scientifically oriented discussions to the point where our discussions get relayed on the The Bald Truth show and almost every other hair loss forum out there. I was amazed at times to see our discussions being posted and translated on French, Dutch and German forums

                            This has been thanks to an influx of members with backgrounds in Biomedical science, Genetics, Pharmacology, Drug Development and Regenrative Medicine….keeping discussions extremely engaging and positive!

                            I hereby ask Baldtruthtalk to please unblock my IP address or at least provide a reason as to why this has happened. I think what is happening right now on BTT is a great thing and Spencer and BTT team should embrace these exciting times rather than try to suppress it…

                            Baldtruthtalk is evolving…let’s evolve with it

                            Also, to all the members who have supported me during the past 8 months I’ve been a member of this great supportive community…please voice your opinions! Without you guys I am powerless…

                            Let’s hope this is not my final post…(And if it is, thanks to everyone who have been so kind to me! You guys most definitely changed my life around)

                            Sending all my balding brothers and sister lots of love from an Internet café nearby!

                            - Desmond

                            Comment

                            • Artista
                              Senior Member
                              • Apr 2010
                              • 2070

                              Hi Desmond, Could it have been a technical issue? You certainly have been positive and have provided much information here. Make sure that you speak with the admins about this before jumping to conclusions bro

                              Comment

                              • Henkeh91
                                Senior Member
                                • Apr 2013
                                • 127

                                Wow.. I'm shocked! It has to be some kind of mistake, you are providing this forum with great news and optimism. I really hope that this isn't your last post.

                                You got my support Desmond! Always

                                Comment

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