7th World Congress for Hair Research (2013)

[Desmond84]

Hey guys, just an update on Dr Jahoda's presentation titled:

"Human hair follicle neogenesis using microenvironmentally reprogrammed dermal papilla cells"

As we discussed earlier, he knows why Aderans failed to regenerate brand NEW follicles!

Previous techniques used by Intercytex, Bioamide and Aderans to culture human DP cells were too simplistic!

He has found human DP cells to be far more complex than its rodent counterpart! So he designed a genius method of culturing DP cells inspired by the way it happens in nature! A 3D spheroidal culturing, which I mentioned briefly earlier!

This new method created DP cells that have maintained most of their trichogenicity! For staticians on this forum, here's some numbers:

- First, look at the method mastered by Aderans: the average correlation coefficient between the transcriptomes of intact DP vs cultured cells is 0.42

- Now look at Jahoda's method: the average correlation coefficient between intact DP vs spheroids it is 0.56, which equates to a significant restoration of an intact DP signature by 3D culture.

I have no doubt that this method of culturing DP in 3D spheroids can be perfected by 3D printers! Australia just launched its first hospital with 3D printers printing cell cultures on bio-scaffolds

Looks like, all these great breakthroughs are happening at just the right time

OMG guys, looks like I was right!!!!!!!

Another group of scientists from Edinburgh University have just announced they are capable of printing 3D stem cells! Here's the most fascinating part:

Dr Will Shu, from Heriot-Watt University in Edinburgh, said: "We found that the valve-based printing is gentle enough to maintain high stem cell viability, accurate enough to produce spheroids of uniform size, and most importantly, the printed hESCs maintained their pluripotency - the ability to differentiate into any other cell type."


These SPHEROIDS are exactly what Dr. Jahoda needs to mass produce DP cells! Good news just keeps on coming!

[Desmond84]

Well, it seems we just can't get enough of Edinburgh!

Scientists at Edinburgh University, Scotland have found the missing link on how to rapidly multiply stem cells!

They found that by genetically modifying stem cells to produce less Oct4 triggers them to rapidly mass produce!!!

Another step closer to true hair multiplication

Three cheers for our Scottish brothers

Here's the link btw:

http://www.scotsman.com/news/education/edinburgh-university-scientists-stem-cell-find-1-2918808

[Desmond84]

ole ole ole ole

[Desmond84]

I got my hands on the journal Unfortunately, I'm not attending as much as I would have loved to!

[Arashi]

BTW, how do you know this Desmond, are you attending the conference ?

[Arashi]

Hey guys, just an update on Dr Jahoda's presentation titled:

"Human hair follicle neogenesis using microenvironmentally reprogrammed dermal papilla cells"

As we discussed earlier, he knows why Aderans failed to regenerate brand NEW follicles!

Previous techniques used by Intercytex, Bioamide and Aderans to culture human DP cells were too simplistic!

He has found human DP cells to be far more complex than its rodent counterpart! So he designed a genius method of culturing DP cells inspired by the way it happens in nature! A 3D spheroidal culturing, which I mentioned briefly earlier!

This new method created DP cells that have maintained most of their trichogenicity! For staticians on this forum, here's some numbers:

- First, look at the method mastered by Aderans: the average correlation coefficient between the transcriptomes of intact DP vs cultured cells is 0.42

- Now look at Jahoda's method: the average correlation coefficient between intact DP vs spheroids it is 0.56, which equates to a significant restoration of an intact DP signature by 3D culture.

I have no doubt that this method of culturing DP in 3D spheroids can be perfected by 3D printers! Australia just launched its first hospital with 3D printers printing cell cultures on bio-scaffolds

Looks like, all these great breakthroughs are happening at just the right time

We're not far guys from a true cure!

Thanks for your always informative posts Desmond ! However 'not far from a cure' sounds a bit too optimistic IMHO. I doubt they could start clinical trials within 2 years and from thereon it's going to be at least another 5 year to get things approved.

But yeah, within a 10 year timeframe, things look very optimistic for sure !

[Artista]

Brother Des' that IS an exciting presentation .. The science of hair is progressing in great ways!!

[Desmond84]

Also, For all the Nigam Lovers out there:

"Dr Nigam is attending the conference and videotaping all the major talks!"...he will be posting them on the forums once he gets back

[Desmond84]

Dr Jahoda is GOD!

Hey guys, just an update on Dr Jahoda's presentation titled:

"Human hair follicle neogenesis using microenvironmentally reprogrammed dermal papilla cells"

As we discussed earlier, he knows why Aderans failed to regenerate brand NEW follicles!

Previous techniques used by Intercytex, Bioamide and Aderans to culture human DP cells were too simplistic!

He has found human DP cells to be far more complex than its rodent counterpart! So he designed a genius method of culturing DP cells inspired by the way it happens in nature! A 3D spheroidal culturing, which I mentioned briefly earlier!

This new method created DP cells that have maintained most of their trichogenicity! For staticians on this forum, here's some numbers:

- First, look at the method mastered by Aderans: the average correlation coefficient between the transcriptomes of intact DP vs cultured cells is 0.42

- Now look at Jahoda's method: the average correlation coefficient between intact DP vs spheroids it is 0.56, which equates to a significant restoration of an intact DP signature by 3D culture.

I have no doubt that this method of culturing DP in 3D spheroids can be perfected by 3D printers! Australia just launched its first hospital with 3D printers printing cell cultures on bio-scaffolds

Looks like, all these great breakthroughs are happening at just the right time

We're not far guys from a true cure!

[UK_]

You can follow the congress on Twitter:

https://twitter.com/hair2013

Not that im that bored.

[Thinning87]

Well sorry man they are not going to come out and say "we found it and it's going to be on sale in a year and it reverses everyone's condition..."

I mean you can tell from the presentations there's a few interesting things moving forward but pretty much that's gonna be it, and you can kind of tell what they are from the abstracts linked by Desmond.

I think the only potential suprises we can have will be Aderans results, developments, and possibly moving to phase 3, and Histogen's results at the 24, 36, and 48 week timelines being better than expected (but that's a long shot); but hopefully they will give hints to things like compoundability, or how HSC can be combined with other treatments... I don't know.... if they told us they have found a partner that would honestly be big too because it would mean they can move forward without making us wait

[john2399]

it says May 8-11 on Histogen's website

I thought the hair congress was may4-7th, i could be mistaken. Either way, the dates or not, good news is all we need.

[Thinning87]

it says May 8-11 on Histogen's website

[Thinning87]

Can't wait to be fully disappointed in the next 3 days=]

wait I thought this was going to start on Monday and end on Wednesday. There are two events one after the otehr right?

[UK_]

Aderans will probably be in phase 2 for the next 50 years.

Looking forward to 50 annual hair loss meetings for exciting updates.