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Probably due to fibrosis.
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So would that mean there's a ceiling where no treatment can exceed beyond until we manage to create new follicles?Comment
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The fibrosis would have to be broken up somehow.This study reported, for the first time, the occurrence of a developing fibrosis of the perifollicular sheath of pattern alopecia. This perifollicular fibrosis was evidenced by the degranulation of follicular adventitial mast cells, as well as enhanced collagen production by neighbouring fibroblasts. In addition, transmission electron microscopy examinations of the lower follicular infundibulum in regions of evolving alopecia indicated that the follicular dermal sheath was characterized by a 2–2.5 times enlargement composed of densely packed collagen bundles.Comment
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They've been pretty successful in reversing cardiac tissue fibrosis lately! I think they were using Adenosine!
May be that should be something for these scientists to think about...we should all discuss these things here. Keep an active open topic about how to reverse these balding areas!
Reversing fibrosis might simply allow more hairs to grow out!Comment
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Wow interesting!
I think there are TWO major phenomenon that we still don't understand about MPB:
1) Why isn't it reversible? (fibrosis is probably the most plausible theory)
2) Catch hairloss upon discontinuing Propecia! (what on earth is going on there)Comment
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Makes sense, but think about it:
- Say, you have taken Propecia for 4 years! All of a sudden you stop Propecia and within 12 months you're back to where you would have been if you didn't take it anyway!
- So, if Propecia was halting hairloss, you would NOT expect things to be so drastically fast if you quit!
- I think, there's a part to the puzzle we are not aware of yet! Propecia may allow the hair to grow but is not stopping whatever underlying damage is going on. And the minute you stop taking it, things fall apart instantly!Comment
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Maybe this catchup hairloss phenomenon is related to PGD2 (i.e. inflammation)!
Maybe blocking PGD2 may not grow more hair, but simply taking it in combination with Propecia may prevent the underlying inflammatory damage!
As a result, once you quit Propecia, you do not suffer from catchup hairloss, but rather a return to the original slow pace of hair thining/receding!
Just a theory
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I think there's alot of variables. DHT, sebum, inflammation, CALCIFICATION. Reducing DHT reduces all of those and allows for hair growth.Comment
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There is theory saying that excessive sebum gives an environment for bacteria to grow, and then your immune system starts attacking (ala acne), which eventually ends in fibrosis. Studies support all of these steps. Yet I think there's more to it. The underlying cause has yet to be discovered, but is probably a number of factors (like calcification of scalp, and UV damage, hair density, body toxification). DHT blockers grow hair. Immune system suppressants grow hair (Cyclosporin A). Some growth factors grow hair. Its possible that Histogens injections work by reducing Cytokine signaling within the scalp, thus allowing hair to grow. Follicles that have fibrosis will likely still not grow though.Maybe this catchup hairloss phenomenon is related to PGD2 (i.e. inflammation)!
Maybe blocking PGD2 may not grow more hair, but simply taking it in combination with Propecia may prevent the underlying inflammatory damage!
As a result, once you quit Propecia, you do not suffer from catchup hairloss, but rather a return to the original slow pace of hair thining/receding!
Just a theoryComment
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You guys are pathetic; just let them get on with it. The fact that it somewhat works,and is better then propecia says a lot.
I think its safe to say, they know more about hair loss related disorders then most guys on here.Comment
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