Aderans hopefully soon

[hellouser]

Histogen say they expect an announcement of results in the next couple of months, so perhaps April is realistic

I've got a feeling they've either got something big, or something very underwhelming. Weird to see early PR like this.

*fingers crossed*

[garethbale]

April for Histogen? Really!? I thought the trials finished in Jan. Thought they'd have results all sorted an make an announcement sooner than April! Hope they're already getting ready to start Phase IIb then.

Histogen say they expect an announcement of results in the next couple of months, so perhaps April is realistic

[UK Boy]

Correct...June for Aderans..I believe April for Histogen

April for Histogen? Really!? I thought the trials finished in Jan. Thought they'd have results all sorted an make an announcement sooner than April! Hope they're already getting ready to start Phase IIb then.

[FearTheLoss]

I think it's cos they added another Phase II trial that started in June 2012 and is due to finish in April of this year. So the update will now come sometime after April - Late May or June maybe??

Correct...June for Aderans..I believe April for Histogen

[UK Boy]

Clandestine is right, anything I say is mere speculation, I myself am rather confused as to how some have stated they are not growing new hair follicles (just "immunizing") as opposed to follicular negenesis (growing new hair follicles).

If they are immunizing follicles and that is only working for 60% of patients then what's the point? Most people have full frontal hair loss in the temples even if they are NW3/4 let alone people who are NW7 and have little/zero adequate donor hair for a transplant.

And what happened to their Phase II update in February???

I think it's cos they added another Phase II trial that started in June 2012 and is due to finish in April of this year. So the update will now come sometime after April - Late May or June maybe??

[UK Boy]

Not 100% sure, I'm just getting the info from the presentation video. He says the cells in their mixture intercalate into existing hair follicle structures and re- programme then or 'turn them back on' for hair growth. So going purely by what he says they should be able to produce hairs in bald areas where there's no hair as long as there is a hair follicle structure that can be turned back on.

[garethbale]

Not trying to cause arguements but Dr. Washnik himself says that they are NOT creating entirely new follicles. Go to around 5:35 of the MESA presentation, this is where he talks about it. They originally hoped to create totally new follicles but the model didn't translate well from mouse to human (Big surprise, lol!). Anywayz he says that they're rejuvinating miniturized follicles so this is why there appears to be hairs where no hairs were before, because the miniturized follicles where "turned back on" in order to start producing hairs again.

I must admit that listening to this again it is better than I originally thought. At first I was thinking that they were only rejuvinating miniturized HAIRS but now I realise it's miniturized FOLLICLES it seems better but still not 100% it's that good :0$

Will they only be able to rejuvinate follicles where hair still grows, like existing treatments, or will they be able to work on slick bald areas as well?

[UK Boy]

https://www.youtube.com/watch?v=l_JH...ature=youtu.be

8:30 onwards:

"On the left there was no hair and on the right there is hair".

Aderans are working on the development of NEW HAIRS where there previously were none, otherwise 90% of their target market will not be interested (NW3,4,5,6 AND 7).

Their procedure is behaving as it should be: regenerating minaturized follicles and also inducing the growth of entirely new hair follicles.

Not trying to cause arguements but Dr. Washnik himself says that they are NOT creating entirely new follicles. Go to around 5:35 of the MESA presentation, this is where he talks about it. They originally hoped to create totally new follicles but the model didn't translate well from mouse to human (Big surprise, lol!). Anywayz he says that they're rejuvinating miniturized follicles so this is why there appears to be hairs where no hairs were before, because the miniturized follicles where "turned back on" in order to start producing hairs again.

I must admit that listening to this again it is better than I originally thought. At first I was thinking that they were only rejuvinating miniturized HAIRS but now I realise it's miniturized FOLLICLES it seems better but still not 100% it's that good :0$

[UK_]

So do u agree/disagree with Des' ascertation that it will make the hairs we have DHT resistant? Also do u reckon the treatment will need to be "topped up" every few years as, from what you are saying, it will induce new non-dht-resistant hairs?

Clandestine is right, anything I say is mere speculation, I myself am rather confused as to how some have stated they are not growing new hair follicles (just "immunizing") as opposed to follicular negenesis (growing new hair follicles).

If they are immunizing follicles and that is only working for 60% of patients then what's the point? Most people have full frontal hair loss in the temples even if they are NW3/4 let alone people who are NW7 and have little/zero adequate donor hair for a transplant.

And what happened to their Phase II update in February???

[clandestine]

He would be speculating.

[Jairus]

https://www.youtube.com/watch?v=l_JH...ature=youtu.be

8:30 onwards:

"On the left there was no hair and on the right there is hair".

Aderans are working on the development of NEW HAIRS where there previously were none, otherwise 90% of their target market will not be interested (NW3,4,5,6 AND 7).

Their procedure is behaving as it should be: regenerating minaturized follicles and also inducing the growth of entirely new hair follicles.

So do u agree/disagree with Des' ascertation that it will make the hairs we have DHT resistant? Also do u reckon the treatment will need to be "topped up" every few years as, from what you are saying, it will induce new non-dht-resistant hairs?

[UK_]

https://www.youtube.com/watch?v=l_JHbtXJ0a8&feature=youtu.be

8:30 onwards:

"On the left there was no hair and on the right there is hair".

Aderans are working on the development of NEW HAIRS where there previously were none, otherwise 90% of their target market will not be interested (NW3,4,5,6 AND 7).

Their procedure is behaving as it should be: regenerating minaturized follicles and also inducing the growth of entirely new hair follicles.

[UK_]

Im sure Aderans were supposed to have a public update in February (update released on their website)? What happened?

[Thinning87]

This video …

http://youtu.be/2oQYjppOPJM

… contains Washenik’s presentation at the Louvres in Paris, France, on March 20, 2011 – so that’s just around 2 years ago.

At this meeting, Washenik didn’t talk about “rejuvenation of existing hair follicle structures” at all. He was just talking about the same old story – follicle neogenesis, aka “brand new follicles from scratch”. He even talked about the involved problems with the angle of new grown follicles/hairs etc etc and finally, about the clinical status of THIS approach.

So WHEN, in fact, did they start with the “rejuvenation” thingy at all?

In the mesa meeting video, he mentioned and showed also a case, where they injected cells EVERYWHERE in the whole tonsure/vertex area (not just sample sites) – right? And?

They have NO CLUE about any longtime effects!
... if there are any 'moderate' effects at all.

What a clown. Always trying to make a big fuzz out of nothing. We all know it's because you hope the new technologies won't lead to anything useful, it's pretty obvious. Obvious is also what this tells us about you. Don't you feel shame for the way you are acting?

Folks, stay patient and cautiously optimistic. In the meantime, cut it short if you still have something, or shave it all off. Or keep up with your regimen, whatever. Just move on with your life, and don't end up like this 5436 guy.

[hellouser]

The value proposition slide in the Nov mesa video says:

"Procedural treatment for long term personalized solution rather than ongoing maintenance therapy"

But they started Phase 2 only in 2008 so how could anyone know what happens 5 years after the procedure?

Well 2008 was 5 years ago so...... yeah.