Aderans hopefully soon

[hgs1989]

I just read a recent paper published by Rodney Sinclair, he presented this at the 2014 World Hair Congress:

http://www.ijtrichology.com/article.asp?issn=0974-7753;year=2014;volume=6;issue=3;spage=88;epage=94;aulast=Torkamani

It doesn't really say if the APM is responsible for growth though... in fact i cant find anything in regards to that.

but there seams to be a connection between irreversible miniaturization and this muscle. we know that once a level of miniaturization is achieved the hair loss is irreversible. lets hope the the connection of APM is a result not the cause of this irreversible loss and once stem cells are awakened everything will return to normal. giving it a second thought, it seems that it is the result. how could they grew human follicle out side of the scalp when the follicles are not attached to such muscle ? who knows. on a different subject, is this japanese team on par with jahoda , lauster, and christiano?

[hellouser]

I actually read about this online after seeing it. it is true. if the follicle loses contact with this muscle the miniaturized hair will not grow. the question is how miniaturized the hair should be to lose contact with this muscle? Man, reading about this makes me really pessimist about any treatment.

I just read a recent paper published by Rodney Sinclair, he presented this at the 2014 World Hair Congress:

http://www.ijtrichology.com/article.asp?issn=0974-7753;year=2014;volume=6;issue=3;spage=88;epage=94;aulast=Torkamani

The APM is considered one of the most important appendageal structures in hair transplant studies. Sato et al. studied single follicular unit transplants in androgenic alopecia (AGA) patients. They demonstrated that restoration of the APM and adjacent nervous system induces the regeneration of the neurofollicular and neuromuscular junctions in the follicle bulge. [8],[48]

It doesn't really say if the APM is responsible for growth though... in fact i cant find anything in regards to that.

[35YrsAfter]

Original article on that:

http://www.nature.com/srep/2012/1205...p00424.html?WT..

Question:

Is the arrector pili muscle required for hair growth? All it does (so far as we know) is contract when we're cold to keep the body warm which causes goosebumps. There's been some talk that the disconnect between the APM and the follicle means irreversible hair loss. But so what? Would it not reconnect itself if the follicle were to return to its normal large size? For instance, hair transplants prove that its capable of connecting itself to the APM, unless the grafts already contain the APM?

Is it any surprise that the connection between the two is lost since the follicle shrinks over time?

An article on the US National Library of Medicine National Institutes of Health has a brief article related to transplanted hair and the APM. Hopefully better future treatments that keep miniaturization under control is all that will be necessary to maintain the APM connection and support decent hair growth.

35YrsAfter also posts as CITNews and works at Dr. Cole's office - forhair.com - Cole Hair Transplant, 1045 Powers Place, Alpharetta, Georgia 30009 - Phone 678-566-1011 - email 35YrsAfter at chuck@forhair.com
The contents of my posts are my opinions and not medical advice
Please feel free to call or email me with any questions. Ask for Chuck

[hgs1989]

Original article on that:

http://www.nature.com/srep/2012/1205...p00424.html?WT..

Question:

Is the arrector pili muscle required for hair growth? All it does (so far as we know) is contract when we're cold to keep the body warm which causes goosebumps. There's been some talk that the disconnect between the APM and the follicle means irreversible hair loss. But so what? Would it not reconnect itself if the follicle were to return to its normal large size? For instance, hair transplants prove that its capable of connecting itself to the APM, unless the grafts already contain the APM?

Is it any surprise that the connection between the two is lost since the follicle shrinks over time?

I actually read about this online after seeing it. it is true. if the follicle loses contact with this muscle the miniaturized hair will not grow. the question is how miniaturized the hair should be to lose contact with this muscle? Man, reading about this makes me really pessimist about any treatment.

[hellouser]

Hmmm really! which study did you find that from I_M?

Here's the one I was reading:
"In our current study, a bioengineered hair follicle, which was ectopically regenerated and matured with the hair shaft, was transplanted into normal skin using the FUT method. The bioengineered hair follicle autonomously rearranged and connected to the recipient cutaneous tissues, such as the skin epithelium, nerve fibers, and the arrector pili muscle. The bioengineered hair follicles also restored inherent hair physiological functions, such as eruption and growth of the hair shafts from the skin surface, maintenance of the proper hair cycles as a result of reproduction of follicular stem cell niche, and piloerection. Our results indicated that the transplantation of the bioengineered hair follicles can be developed into a viable alternative to conventional FUT therapy for future hair regenerative therapies."

The pictures they posted with this study says the hair naturally erupted after 22 days!

Original article on that:

http://www.nature.com/srep/2012/1205...p00424.html?WT..

Question:

Is the arrector pili muscle required for hair growth? All it does (so far as we know) is contract when we're cold to keep the body warm which causes goosebumps. There's been some talk that the disconnect between the APM and the follicle means irreversible hair loss. But so what? Would it not reconnect itself if the follicle were to return to its normal large size? For instance, hair transplants prove that its capable of connecting itself to the APM, unless the grafts already contain the APM?

Is it any surprise that the connection between the two is lost since the follicle shrinks over time?

[Thinning87]

I agree that their way of freaking out every two weeks is annoying but it's hard to see the selling of all equipment as a positive sign...

I guess we'll have to watch tomorrow's show to find out more

[UK_]

Tell me about it, so they're selling a lot of their equipment, all of a sudden its doomsday.

[PayDay]

well Spencer received a call from ARI during the last show, so it would be nice if he could fill us in on what they said when he called them back

You guys are so funny and have such a strange sense of entitlement. First someone says that Spencer received a call from Dr. Washenick. Now you're claiming that is was actually from ARI. I don't remember hearing him say that, but I will admit that I was working when I was listening to the live show. Either way, if this is true, how do you know it wasn't just a social call, or maybe to talk about a future interview or whatever? Right know it's just a rumor anyway and if true probably completely taken out of context like so many things are on the forum.

I am sure Kobren will fill us in on anything that is happening when he is able to. Give the guy a break already. He doesn't control what these companies say or do.

[FearTheLoss]

well Spencer received a call from ARI during the last show, so it would be nice if he could fill us in on what they said when he called them back

[UK_]

You know what's really surprising to me! The fact that they know we know! But they refuse to release an official statement explaining the situation...Makes you wonder if all the horror stories about Bosley are true?

Or the past 'horror stories' of forum members being totally wrong regarding speculative statements.

[bibz]

Damn just shut your mouth with all these fvcking comments, there is no official announcment of the end of Ji Gami, so until that just stop speculate like girls

[Thinning87]

I'm seriously concerned that this may be 'it' for Big Pharma attempts at funding hair regeneration treatments, at least for a very long time.

Dude reading your comments makes me vomit. They're so depressing, you're such a woman

[Pentarou]

Ah, now we know where the liquidation money will go.

I'm seriously concerned that this may be 'it' for Big Pharma attempts at funding hair regeneration treatments, at least for a very long time.

[Vox]

There's heaps of anecdotal reports...I also came across this site last week when I was looking for subsidiary's of Aderans:

http://www.bosleymedicalviolations.com/

Scared me for sure! Patient stories sound horrible!

Wow, frightening stuff! I had no idea about it.

[garethbale]

You know what's really surprising to me! The fact that they know we know! But they refuse to release an official statement explaining the situation...Makes you wonder if all the horror stories about Bosley are true?

Well according to someone on here who contacted one of their staff, they are not discontinuing their Ji Gami work. Wouldn't be surprised if management were keeping that employee in the dark as well though!